Protein Alignment Sur and abcc5

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_001182542.1
• Gene: abcc5 / 336147
• ZFINID: ZDB-GENE-050517-17
• Length: 1426
• Species: Danio rerio
• Alignment Length: 2050
• Identity: 458/2050 - (22%)
• Similarity: 736/2050 - (35%)
• Gaps: 750/2050 - (36%)

  Fly   214 DDYGKIGYKHSM------------------ATFYSKSCFWWLTPLLWLGYKE-PLELEDLGQMKL 259
            |..|:..|.||:                  |..:|...|.|||.|..|.:|: .|.|||:..:..
Zfish    69 DAAGRSKYHHSVCVLKPIRSTSKYQHPVDNAGLFSFMTFNWLTSLAVLAHKKGQLFLEDIWAVSQ 133

  Fly   260 EDSARSHYDHFLYIYTEKKKKSNSSPSL----W-YCYIKNSWQMFALGGILKLAGDLFALIGP-L 318
            .:|...:......::.|:.:...:..||    | :|..:....:..| .:.:|||    ...| .
Zfish   134 FESCEINRRRLAGLWEEEIRSRGNDASLRRVVWHFCRTRLLLSILCL-MVTQLAG----FSSPAF 193

  Fly   319 AIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLL 383
            .:.:::|     |.|.|||       ::...||....:|.||                      |
Zfish   194 VVWRLLE-----YTQRSEP-------DLPYGLLLVLGLLATE----------------------L 224

  Fly   384 ANGWCIAWIVLLAAITQGALSQASTHILN-MTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQ 447
            ...|                |.|.|..|| .||.|::.::..:.:.|.|.|
Zfish   225 IRSW----------------SHALTWALNYRTGTRLRGAILTMAFHKILRL-------------- 259

  Fly   448 VQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPF 512
                      :...:.||                  |.:.|..:.|.:.:.|...:.......|.
Zfish   260 ----------RSLREKSM------------------GELINMCSGDGQRMFEAAAVGSLLAGGPL 296

  Fly   513 KIAV--VIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVG 575
             :||  :.|.|:: ||.::::|| |..::..|...|.....:.........||:|::::::.|..
Zfish   297 -VAVLGMAYNLFV-LGPTSLLGS-AVFILFYPTMMFSSRLTAYFRRKGVAVTDQRVQKMNEILNY 358

  Fly   576 IKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQE 640
            ||.||:.||.:.|.:.::..|.:|.:.|.:...|.::...:..|..|:.:..|...::.|    .
Zfish   359 IKFIKMYAWVKAFSQAVRRIRDEERQILERTGYFQSITVGVAPIVVVIASVATFSTHMLL----G 419

  Fly   641 FDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARIL 705
            :||.|::.|:.:.:|..:|..|.:.|.:|..:..|.|:..|.:..|..:|::...|..||.:..:
Zfish   420 YDLTAAQAFTVVTVFNAMTFALKVTPFSVKSLSEASVAIDRFKSLLLMAEVKMIRELPRNPSVAV 484

  Fly   706 SKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPST 770
            ..|.||| .:||...|                  ||.|.
Zfish   485 EMSGASL-AWETGGHS------------------AQPSP-------------------------- 504

  Fly   771 VQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDI 835
                             |.||:|..|..:.:....:.|...:::....     ...||..:..::
Zfish   505 -----------------RGTPHVGTRGCRKKRRQRDVPKHHAILEEET-----HGQLLNDVSGEM 547

  Fly   836 AVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFW 900
            |.|..|........||.....||...:.:.||||..|.|..|||||||:||:|.:|.||.|
Zfish   548 ASSPKDQTLHVPTISQRLQRTLHCIDLSIQKGKLVGVCGSVGSGKTSLISAILGQMTLLEG---- 608

  Fly   901 HKTCTI----SYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGE 961
              |..:    :||:||.|:||.:.|:|||||:....:||..:|.||.|:||:.::|.|||:.|||
Zfish   609 --TVAVDGDFAYVAQQAWILNASFRDNILFGKEMEEERYQAILSACCLRPDLAMLPSGDLTEIGE 671

  Fly   962 RGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQ 1026
            ||.|:||||||||::|||:||:..:.|:||||::||..||.|||.:.|::.|:  .:|.|.||.|
Zfish   672 RGANLSGGQRQRISLARALYSNRGIYILDDPLSALDAHVGNHIFNNAIKKQLR--GKTVIFVTHQ 734

  Fly  1027 LHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERW 1091
            |..:.:.:.:|.::||.:...||:.|:..:.....|.:|
Zfish   735 LQYLVDCDDVIVMRDGSIAEQGSHEDLMNVNGDYAAMFN-------------------------- 773

  Fly  1092 KLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGG 1156
                                                                             
Zfish   774 ----------------------------------------------------------------- 773

  Fly  1157 FNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTAT 1221
             |||                                     ||
Zfish   774 -NLQ-------------------------------------LG---------------------- 778

  Fly  1222 SESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPP 1286
                                                                          ..|
Zfish   779 --------------------------------------------------------------ETP 781

  Fly  1287 AMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSI 1351
            .:||.|         ::|.:|.:.||:....||.::
Zfish   782 IIEVPN---------KKSGSSLKKPLEKSKAGSVKK----------------------------- 808

  Fly  1352 SEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSP 1416
             |:|           .|.|:....|.||:
Zfish   809 -EKS-----------TTQGDGQLMQVEER------------------------------------ 825

  Fly  1417 ADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRA-AGLPIITIFFITA 1480
                               |:.|:|.|                :|.:||:| .|.|:  ..||.|
Zfish   826 -------------------GKGSVPWA----------------VYKVYIQALGGWPV--FLFILA 853

  Fly  1481 LI------------WQCLRVYTDIWLQQWS-NVHGRVASKGHVVLHPSEQDHE-VTYYFRMYAAI 1531
            |.            |.|      .|::|.| |...:|.:..  ||..|.:|:. :.:|..:|...
Zfish   854 LFILNVGSTAFSNWWLC------YWIKQGSGNTTVQVGNSS--VLSESMRDNPLMQHYAAVYTMS 910

  Fly  1532 SCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKI 1596
            ..|.:::.|:...........|...|||:|.|.||...:.||..||..||:||||.||..:|.::
Zfish   911 MGVMLLLKLLRGIVFVKGTLRASSRLHDELFQKILRSPMKFFDTTPTARILNRFSKDMDEVDTRL 975

  Fly  1597 AATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVI 1661
            ....:...|..:|.|..:.:..::.||.||...|:...:.::....|...|||:|::|.|.||.:
Zfish   976 PFQAEMFTQNVILVLFCLAVIGSVFPWFLVAVGPLVLLFTVLHVVSRVFIRELKRLDNVTQSPFL 1040

  Fly  1662 SHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVT 1726
            ||::.:|||:||:.|:.::..|.....:.|:.|...:.|.:.:.|||.|.||.:.   |.:.::|
Zfish  1041 SHIASSIQGLTTVHAYGKEDEFLHRYQELLDQNQAPFYLFSCAMRWLAVRLDVIS---VALISIT 1102

  Fly  1727 ALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVV 1791
            ||....:    |.:.                           .|:..||||:|.:.:.....:.|
Zfish  1103 ALMIVLM----HGQI---------------------------PPAYAGLAISYAVQLTGLFQFTV 1136

  Fly  1792 KLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGD 1856
            :|.::.|....|||||.||.:....:|
Zfish  1137 RLASETEARFTSVERIHHYIKSLSLEA-------------------------------------- 1163

  Fly  1857 KVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHH 1921
                                                                             
Zfish  1164 ----------------------------------------------------------------- 1163

  Fly  1922 PPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDN 1986
                                                    |||  .:.::.|..|||.|:|.||.
Zfish  1164 ----------------------------------------PAR--VKNKAPPSDWPQEGEIVFDQ 1186

  Fly  1987 VSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIR 2051
            ..::|......::...:..:...::|||.|||||||||||:.|:.:::...|.|.||.|:|..|.
Zfish  1187 TEMKYRDNLPLILKKASFTVRPKEKIGIVGRTGSGKSSLGVVLYRLVEPCGGSIKIDGVNICDIG 1251

  Fly  2052 PDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDG 2116
            ..::|::||||||:..||:.|:|.||||...:.:.|:|:.||...:||.|: .|||.|::.:.:.
Zfish  1252 LADVRSKLSIIPQEPVLFSGTVRSNLDPFSQYSEAQIWDALERTHMKECVS-QLPLKLESEVVEN 1315

  Fly  2117 GLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTI 2181
            |.|.|.|.|||||:||.:||....|:|||||:.:.:.|:..:.:....||:..|.:|||||:.|:
Zfish  1316 GENFSVGERQLLCVARVLLRQCKILILDEATAAMGTETDCLIQETIRNAFQDCTTLTIAHRVHTV 1380

  Fly  2182 LDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGLL 2216
            |..||::||:||::||...|.:|...|.|.|..:|
Zfish  1381 LSCDRIMVLNQGQVVEFDEPSKLLANENSRFCAML 1415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	77/384 (20%)
		TM helix 1	301..324	CDD:350035	5/23 (22%)
		TM helix 2	385..433	CDD:350035	11/48 (23%)
		TM helix 3	480..525	CDD:350035	9/46 (20%)
		TM helix 4	526..575	CDD:350035	10/48 (21%)
		TM helix 5	587..631	CDD:350035	8/43 (19%)
		TM helix 6	648..681	CDD:350035	8/32 (25%)
		ABCC_MRP_domain1	837..1043	CDD:213217	93/209 (44%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	95/349 (27%)
		TM helix 1	1475..1496	CDD:350046	7/32 (22%)
		TM helix 2	1520..1568	CDD:350046	12/48 (25%)
		TM helix 3	1575..1620	CDD:350046	14/44 (32%)
		TM helix 4	1621..1670	CDD:350046	17/48 (35%)
		TM helix 5	1682..1727	CDD:350046	11/44 (25%)
		TM helix 6	1777..1810	CDD:350046	10/32 (31%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	91/220 (41%)
abcc5	NP_001182542.1	intraplasmic N-terminal	1..59
		transmembrane domain 1	59..149		19/79 (24%)
		MRP_assoc_pro	95..1405	CDD:188098	449/2012 (22%)
		nucleotide binding domain 1	188..248		22/109 (20%)
		transmembrane domain 2	279..379		24/102 (24%)
		nucleotide binding domain 2	403..450		12/50 (24%)