Protein Alignment Sur and Abcc6

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: XP_006541009.1
• Gene: Abcc6 / 27421
• MGIID: 1351634
• Length: 1500
• Species: Mus musculus
• Alignment Length: 2122
• Identity: 425/2122 - (20%)
• Similarity: 680/2122 - (32%)
• Gaps: 844/2122 - (39%)

  Fly    43 IFLLLFG---LMFVCSRYKKCHKTLLTFHNGRAAISLLLLALNSFDLARIFLPHQNVRNLNRLFQ 104
            ::|.:.|   |::: .|:.:|:..:......:..:.|.|:.|.:|::|   :|      |.|:.|
Mouse   116 MYLWVLGPIYLLYI-HRHGRCYLRMSHLFKTKMVLGLALILLYTFNVA---VP------LWRIHQ 170

  Fly   105 SSPRDLNYLVVIGSGELWNALFSTLLTLMLMLYHRMVERKKATVFLY---------ASTAVEALT 160
            ..|:....|:   ...:|....| ..|.::.:..|...|....:|.|         .:|..:|..
Mouse   171 GVPQAPELLI---HPTVWLTTMS-FATFLIHMERRKGVRSSGVLFGYWLLCCILPGINTVQQASA 231

  Fly   161 FALLSNELFELVRYEDFLELQTCLVAMSAMCMVSLAMLDGLTVYKECYHDDYLDDYGKIGYKHSM 225
            .......|..|..|       .||..:.|..::| .::|....:.|       |.........:.
Mouse   232 GNFRQEPLHHLATY-------LCLSLVVAELVLS-CLVDQPPFFSE-------DSQPLNPCPEAE 281

  Fly   226 ATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSAR------------------SHYDHF-- 270
            |:|.||:.|||.:.|||.|||:.|..:||..:..|:|:.                  .|..|.
Mouse   282 ASFPSKAMFWWASGLLWRGYKKLLGPKDLWSLGRENSSEELVSQLEREWRRSCNGLPGHKGHSSV 346

  Fly   271 ------LYIYTEKKKKSNSSPSLWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQ 329
                  .::..|:.::.....::|..:...    |.||.:..:..|.|....|..:...:|::
Mouse   347 GAPETEAFLQPERSQRGPLLRAIWRVFRST----FLLGTLSLVISDAFRFAVPKLLSLFLEFM-- 405

  Fly   330 LYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVL 394
                         |:.                             .||.|:     ||.:|.::.
Mouse   406 -------------GDR-----------------------------NSSAWT-----GWLLAVLMF 423

  Fly   395 LAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQ 459
            .||..|....|...:...:..:|::|::.||:|||.|:|          |:|..:|:::
Mouse   424 AAACLQTLFEQQHMYRAKVLQMRLRTAITGLVYRKVLVL----------SSGSRKSSAA------ 472

  Fly   460 KNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMN 524
                                    |.:.|.::.|.:.:.|..:.::..|.:...|.|....|:..
Mouse   473 ------------------------GDVVNLVSVDIQRLAESIIYLNGLWLLFLWIFVCFVYLWQL 513

  Fly   525 LGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFL 589
            ||.|| :.::|..:.:.||.|||......:.|........|.:.....|..::.||.:.|:..||
Mouse   514 LGPSA-LTAVAVFLSLLPLNFFITKKRGFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWEHAFL 577

  Fly   590 KKIQEARRKELKYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLAL 654
            :::...|.:||..|......:::..|...::|.|:..|...|:..:..|...|  |.:.|.:|.:
Mouse   578 ERLLHIRGQELSALKTSTLLFSVSLVSFQVSTFLVALVVFAVHTLVAEDNAMD--AEKAFVTLTV 640

  Fly   655 FQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQE 719
            ...|.......|.:|..|:.||||..||..||...|:                           :
Mouse   641 LSILNKAQAFLPFSVHCIVQARVSFDRLAAFLCLEEV---------------------------D 678

  Fly   720 KSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRR 784
            .:.|                               :..|:..|::|
Mouse   679 PNGM-------------------------------IASNSRRSSKD------------------- 693

  Fly   785 ELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQ 849
                                                               .:|:::|.|.|..:
Mouse   694 ---------------------------------------------------RISVHNGTFAWSQE 707

  Fly   850 SQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPW 914
            |. |.  ||...:.||:|.|..|||..|:||:|||||||.|:..:.|::....  :::||.|:.|
Mouse   708 SP-PC--LHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEG--SVAYVPQEAW 767

  Fly   915 LLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARA 979
            :.|.::.||:.|.:.........||:||||..|:...|.|..:.|||:|:|:||||:||:::|||
Mouse   768 VQNTSVVENVCFRQELDLPWLQKVLDACALGSDVASFPAGVHTPIGEQGMNLSGGQKQRLSLARA 832

  Fly   980 IYSSANVVIMDDPLASLDNEVGEHIFQHCI--REMLQKSNRTFILVTQQLHRIKEAEYLIAIKDG 1042
            :|..|.:.::|||||:||..|.:.:|:..|  ..:||.:.|  ||||..||.:.:|:.::.:.:|
Mouse   833 VYKKAAIYLLDDPLAALDAHVSQQVFKQVIGPSGLLQGTTR--ILVTHTLHVLPQADRILVLANG 895

  Fly  1043 RVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSIS 1107
            .:...|||.|:                                       |.:|.:.:||
Mouse   896 TIAEMGSYQDL---------------------------------------LQRNGALVGL----- 916

  Fly  1108 VTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHL 1172
                         :||:                     ..|.|.                   |
Mouse   917 -------------LDGA---------------------RQPAGT-------------------H- 927

  Fly  1173 MYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVL 1237
                    |....||                        |.|.
Mouse   928 --------DAATSDD------------------------LGGF---------------------- 938

  Fly  1238 ATSCSSYAESSVDGGDLATAAPE-PRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEA 1301
                        .||...|..|: ||         .|...|:...::|...||.:
Mouse   939 ------------PGGGRPTCRPDRPR---------PTEAAPVKGRSTSEVQMEAS---------- 972

  Fly  1302 RRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASIL 1366
                      |||
Mouse   973 ----------LDD---------------------------------------------------- 975

  Fly  1367 ATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEV 1431
                                                                          .|.
Mouse   976 --------------------------------------------------------------PEA 978

  Fly  1432 AGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQ 1496
            .|.:..|         |:.| ||::...|||.|:||.|.|:.|......|..|........||..
Mouse   979 TGLTAEE---------DSVR-YGRVKTTIYLSYLRAVGTPLCTYTLFLFLCQQVASFSQGYWLSL 1033

  Fly  1497 WSN---VHGR---VASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARR 1555
            |::   |.||   .|.:|.|                 :..:.|:..|....|..|....|..|..
Mouse  1034 WADDPVVDGRQMHAALRGWV-----------------FGLLGCLQAIGLFASMAAVFLGGARASG 1081

  Fly  1556 NLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTI 1620
            .|...||..:....:.||:.||:|.::||||.:...:|..|....:.||.:....|...|.....
Mouse  1082 LLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDTVDVDIPDKLRSLLTYAFGLLEVGLAVTMA 1146

  Fly  1621 TPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFT- 1684
            ||..:|..||:...|...|..|..::.:|:|:|:|..|.|.||::||.||...:|||..|..||
Mouse  1147 TPLAIVAILPLMVLYAGFQSLYVATSCQLRRLESARYSSVCSHMAETFQGSLVVRAFRAQASFTA 1211

  Fly  1685 ----------EILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHY 1739
                      .:.|.:|.|:           |||..:|:.||..:||||...|:.
Mouse  1212 QHDALMDENQRVSFPKLVAD-----------RWLATNLELLGNGLVFVAATCAVL---------- 1255

  Fly  1740 EATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSV 1804
                                    |:...|..|||.:::..|.|...|.|||:...|:|....:|
Mouse  1256 ------------------------SKAHLSAGLVGFSVSAALQVTQTLQWVVRSWTDLENSMVAV 1296

  Fly  1805 ERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDV 1869
            ||:..||:
Mouse  1297 ERVQDYAR--------------------------------------------------------- 1304

  Fly  1870 DEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQAT 1934
                                                                             
Mouse  1305 ----------------------------------------------------------------- 1304

  Fly  1935 TKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVI 1999
                                   :|.|...:|....:.|: ||..|.|.|.:..||:..:....:
Mouse  1305 -----------------------IPKEAPWRLPTCAAQPL-WPCGGQIEFRDFGLRHRPELPLAV 1345

  Fly  2000 SNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQ 2064
            ..::|||.||:::||.||||:|||||...|..:.:...|:|:||.|.|..:....||:|::||||
Mouse  1346 QGVSLKIHAGEKVGIVGRTGAGKSSLAWGLLRLQEAAEGNIWIDGVPITHVGLHTLRSRITIIPQ 1410

  Fly  2065 DVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLP 2106
            |..||..::|.|||......|..:|..||..|||.||.. ||
Mouse  1411 DPVLFPGSLRMNLDLLQEHTDEGIWAALETVQLKAFVTS-LP 1451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	77/380 (20%)
		TM helix 1	301..324	CDD:350035	5/22 (23%)
		TM helix 2	385..433	CDD:350035	15/47 (32%)
		TM helix 3	480..525	CDD:350035	8/44 (18%)
		TM helix 4	526..575	CDD:350035	12/48 (25%)
		TM helix 5	587..631	CDD:350035	10/43 (23%)
		TM helix 6	648..681	CDD:350035	10/32 (31%)
		ABCC_MRP_domain1	837..1043	CDD:213217	80/207 (39%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	91/352 (26%)
		TM helix 1	1475..1496	CDD:350046	4/20 (20%)
		TM helix 2	1520..1568	CDD:350046	9/47 (19%)
		TM helix 3	1575..1620	CDD:350046	13/44 (30%)
		TM helix 4	1621..1670	CDD:350046	18/48 (38%)
		TM helix 5	1682..1727	CDD:350046	15/55 (27%)
		TM helix 6	1777..1810	CDD:350046	11/32 (34%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	53/127 (42%)
Abcc6	XP_006541009.1	MRP_assoc_pro	101..1465	CDD:188098	425/2122 (20%)