DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur and mrp-1

DIOPT Version :9

Sequence 1:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_001024719.2	Gene:	mrp-1 / 180409	WormBaseID:	WBGene00003407	Length:	1534	Species:	Caenorhabditis elegans

Alignment Length:	2234	Identity:	518/2234 - (23%)
Similarity:	815/2234 - (36%)	Gaps:	810/2234 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 TFFSIFLLLFGLMFVCSRYKKCHKTLLTFHNGRAAISLLLL--ALNSFDLARIFLPHQNVRNLNR 101
            |..::||::|..:.....||..:..|.:|    :||||.::  .|...||....     :.:...
Worm    41 TIPTLFLVIFSPILFYELYKSRNSYLRSF----SAISLRIIFCCLLVVDLTATV-----IYDFYL 96

  Fly   102 LFQSSPRDLNYLVVIGSGELWNAL-----------FSTLLTLMLMLYHR-MVERKKATVF--LYA 152
            ||..||             |:||:           |...|.|.:...:| ::.....|::  |..
Worm    97 LFTKSP-------------LYNAIHFYGDLVQYAGFCLALVLTIACRNRGIITSGVITLYWLLVV 148

  Fly   153 STAVEALTFALLSNELFELVRYEDFLELQTCLVAMSAMCMVSLAMLDGLTVYKECYHDDYLDDY- 216
            ...|..|.:.:...      .|::: |:.:|..|:.....|..|    |.::..|:.|...:.|
Worm   149 VCGVPELRYYITGR------LYKEY-EIHSCRAALYVFAYVCSA----LELFLSCFADTPSNGYI 202

  Fly   217 GKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYI-------Y 274
            ||.......|:|.::..|.|.:.|.:||.|:.||.|||..:...|.|.:....|:..       |
Worm   203 GKNSCPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAENIIPSFIENLIPEVEGY 267

  Fly   275 TEKKKKS------NSSPSLWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQ 333
            ..|.||:      .:.||:.....|........||..||..||...:.|..:::::.:||    .
Worm   268 RRKIKKNPEAAIPKNHPSILIPIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIE----D 328

  Fly   334 ASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAI 398
            .::|                                        .|.     |..||.::.|:::
Worm   329 KNQP----------------------------------------MWI-----GVSIALLMFLSSL 348

  Fly   399 TQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDD 463
            .|..:.....|.:...|:.|::.|...:|.|:|.|                     |:|.:|...
Worm   349 LQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNL---------------------SNEARKGKT 392

  Fly   464 SMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGIS 528
            :                   |:|.|.|:.|.:.|.:....|...|:.|.:|.:.:|.|:..||:|
Worm   393 T-------------------GAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVS 438

  Fly   529 AVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQ 593
            .:.|.: .::::.|...||...|.........:.|||:|.:.:.|.|:||:||.:|::...|.:.
Worm   439 VLAGFV-ILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVL 502

  Fly   594 EARRKE------LKYLNKDATF-WTLMAVLTHIATVLITFVTLGVYV-WLHRDQEFDLNASRL-F 649
            |.|.||      |.|||...|. |.       .|..|:..:|.|:|| |   |.|.::...:: |
Worm   503 EVREKEIRVLKKLSYLNAATTLSWA-------CAPFLVAVLTFGLYVLW---DPENNVLTPQITF 557

  Fly   650 SSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDM 714
            .:||||..|..||.:|.:.....:....|..||:.|.
Worm   558 VALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFF---------------------------- 594

  Fly   715 YETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKL 779
                                                           :||::||.|....|
Worm   595 -----------------------------------------------AAEEMSPQTSIAYG---- 608

  Fly   780 VQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLF 844
                                                  .|||              |:.::.|.|
Worm   609 --------------------------------------GTDS--------------AIKMDGGSF 621

  Fly   845 TWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYV 909
            .|..:.:..  :||.....:.:|:|..:||:.||||:|||.|||.||..|:|::  ....:::||
Worm   622 AWGSKEEDR--KLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSV--QVNGSVAYV 682

  Fly   910 SQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRI 974
            .|..|:.|.::|.||||...:..|.|..|:|.|||..|:|.:|..|.:.|||:|||:||||:||:
Worm   683 PQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRV 747

  Fly   975 AIARAIYSSANVVIMDDPLASLDNEVGEHIFQH-------CIREMLQKSNRTFILVTQQLHRIKE 1032
            ::|||:|.:|.:|::||||:::|:.||:|||::       |:      ..:|.:|:|..|..:|.
Worm   748 SLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCL------GTKTRVLLTHGLTYLKH 806

  Fly  1033 AEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNV 1097
            .:.:|.:||..:...|:|.::
Worm   807 CDQVIVLKDETISEMGTYQEL-------------------------------------------- 827

  Fly  1098 SKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRK 1162
                        |::|.|.                 |..:||                 |.|:
Worm   828 ------------MNSNGAF-----------------SEFLEE-----------------FLLE-- 844

  Fly  1163 RSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSI 1227
                                                        .|.|:
Worm   845 --------------------------------------------ESKHK---------------- 849

  Fly  1228 SGDVLSRSVLATSCSSYAESSVDGGDL------ATAAPEPRVQSWQPPQHVTHHQPLSRNASSPP 1286
                 .|||      |:.|.|.:..:|      .:.|...|:||..
Worm   850 -----GRSV------SFGEDSKEVNELLRDLDQVSPAIRQRIQSQM------------------- 884

  Fly  1287 AMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSI 1351
            :.|:...|.|.:|..|..                                .|....:|.:||
Worm   885 SQEIEKTDDKNAEIIRNG--------------------------------LHKDEQTAHSSI--- 914

  Fly  1352 SEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSP 1416
                                   .:||||......|..||.|                      |
Worm   915 -----------------------GKSEEKESLLGAISPKEKT----------------------P 934

  Fly  1417 ADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITAL 1481
            ...:|...:.:..|               |::|    ||:..::|:.|.||.|:.|..:||:..:
Worm   935 EPPKQTKTQLIEKE---------------AVET----GKVKFEVYMSYFRAIGIKIALVFFLVYV 980

  Fly  1482 IWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEVTYYFRMYAAI-----SCVC---IIM 1538
            ....|.|:::::|.:||:....:|..|      :....|......:||.:     :.||   |||
Worm   981 ASSMLGVFSNLYLARWSDDAKEIALSG------NGSSSETQIRLGIYAVLGMGQATSVCAASIIM 1039

  Fly  1539 ALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRL 1603
            ||...       | |.|.||..||:.|:...:.||.|||||||:|||..|:..:|..|..|....
Worm  1040 ALGMV-------C-ASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDVDGVDTDIPRTMSMF 1096

  Fly  1604 LQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETI 1668
            ::..:..:..|.|.:..||..:.|.||:...|:::.:||..::|:|:|:|:|:.||:.||..|:|
Worm  1097 IRTAVSSIEIIAIILWATPLAISLLLPLFIVYFVVLRFYVSTSRQLKRLESASRSPIYSHFQESI 1161

  Fly  1669 QGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASV 1733
            ||.::|||:....:|......|::.|...|.....::|||.|.|:.:|..||.     :...|:|
Worm  1162 QGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVL-----SSAGAAV 1221

  Fly  1734 SCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADME 1798
            ..|      .||..||                     .||||:::|.|.:...|||.|::.:::|
Worm  1222 YFR------DSPGLSA---------------------GLVGLSVSYALNITQTLNWAVRMTSELE 1259

  Fly  1799 MYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGAT 1863
            ....:||||..|.                              ::.....:|||.|
Worm  1260 TNIVAVERINEYT------------------------------ITPTEGNNSQSLA--------- 1285

  Fly  1864 TAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGD 1928

Worm  1286 ----------------------------------------------------------------- 1285

  Fly  1929 KVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEG 1993
                                                        |.|||:.|:|...|.|:||..
Worm  1286 --------------------------------------------PKSWPENGEISIKNFSVRYRP 1306

  Fly  1994 QKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTR 2058
            ....|:..:|..|...::|||.||||:|||||.|:||.:::...|.|.||..:|..:..::||:|
Worm  1307 GLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSR 1371

  Fly  2059 LSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAG 2123
            |:|:|||..||:.|:|.||||...|.|.|:|..|..|.|..||.. |..||...|.:||.|||.|
Worm  1372 LTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKS-LQEGLHHHISEGGENLSVG 1435

  Fly  2124 HRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLI 2188
            .|||:|||||:||.:..||||||.:.:|..|:|.|.|.....|:..|::||||||.|::|.|||:
Worm  1436 QRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLL 1500

  Fly  2189 VLDQGRIVEDGNPRELQQLEGSVF 2212
            |||:|.:.|...|::|......:|
Worm  1501 VLDKGCVAEFDTPKKLLSNPDGIF 1524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
mrp-1	NP_001024719.2	MRP_assoc_pro	23..1531	CDD:188098	518/2234 (23%)
		ABC_membrane	309..570	CDD:294371	80/360 (22%)
		ABCC_MRP_domain1	614..815	CDD:213217	79/210 (38%)
		ABC_membrane	976..1248	CDD:279056	93/317 (29%)
		ABCC_MRP_domain2	1293..1513	CDD:213211	103/220 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010