Protein Alignment Sur and mrp-1

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_508122.2
• Gene: mrp-1 / 180409
• WormBaseID: WBGene00003407
• Length: 1534
• Species: Caenorhabditis elegans
• Alignment Length: 2242
• Identity: 523/2242 - (23%)
• Similarity: 816/2242 - (36%)
• Gaps: 826/2242 - (36%)

  Fly    39 TFFSIFLLLFGLMFVCSRYKKCHKTLLTFHNGRAAISLLLL--ALNSFDLARIFLPHQNVRNLNR 101
            |..::||::|..:.....||..:..|.:|    :||||.::  .|...||....     :.:...
 Worm    41 TIPTLFLVIFSPILFYELYKSRNSYLRSF----SAISLRIIFCCLLVVDLTATV-----IYDFYL 96

  Fly   102 LFQSSPRDLNYLVVIGSGELWNAL-----------FSTLLTLMLMLYHR-MVERKKATVF--LYA 152
            ||..||             |:||:           |...|.|.:...:| ::.....|::  |..
 Worm    97 LFTKSP-------------LYNAIHFYGDLVQYAGFCLALVLTIACRNRGIITSGVITLYWLLVV 148

  Fly   153 STAVEALTFALLSNELFELVRYEDFLELQTCLVAMSAMCMVSLAMLDGLTVYKECYHDDYLDDY- 216
            ...|..|.:.:...      .|::: |:.:|..|:.....|..|    |.::..|:.|...:.|
 Worm   149 VCGVPELRYYITGR------LYKEY-EIHSCRAALYVFAYVCSA----LELFLSCFADTPSNGYI 202

  Fly   217 GKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYI-------Y 274
            ||.......|:|.::..|.|.:.|.:||.|:.||.|||..:...|.|.:....|:..       |
 Worm   203 GKNSCPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAENIIPSFIENLIPEVEGY 267

  Fly   275 TEKKKKS------NSSPSLWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQ 333
            ..|.||:      .:.||:.....|........||..||..||...:.|..:::::.:||    .
 Worm   268 RRKIKKNPEAAIPKNHPSILIPIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIE----D 328

  Fly   334 ASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAI 398
            .::|                                        .|.     |..||.::.|:::
 Worm   329 KNQP----------------------------------------MWI-----GVSIALLMFLSSL 348

  Fly   399 TQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDD 463
            .|..:.....|.:...|:.|::.|...:|.|:|.|                     |:|.:|...
 Worm   349 LQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNL---------------------SNEARKGKT 392

  Fly   464 SMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGIS 528
            :                   |:|.|.|:.|.:.|.:....|...|:.|.:|.:.:|.|:..||:|
 Worm   393 T-------------------GAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVS 438

  Fly   529 AVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQ 593
            .:.|.: .::::.|...||...|.........:.|||:|.:.:.|.|:||:||.:|::...|.:.
 Worm   439 VLAGFV-ILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVL 502

  Fly   594 EARRKE------LKYLNKDATF-WTLMAVLTHIATVLITFVTLGVYV-WLHRDQEFDLNASRL-F 649
            |.|.||      |.|||...|. |.       .|..|:..:|.|:|| |   |.|.::...:: |
 Worm   503 EVREKEIRVLKKLSYLNAATTLSWA-------CAPFLVAVLTFGLYVLW---DPENNVLTPQITF 557

  Fly   650 SSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDM 714
            .:||||..|..||.:|.:.....:....|..||:.|.
 Worm   558 VALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFF---------------------------- 594

  Fly   715 YETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKL 779
                                                           :||::||.|....|
 Worm   595 -----------------------------------------------AAEEMSPQTSIAYG---- 608

  Fly   780 VQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLF 844
                                                  .|||              |:.::.|.|
 Worm   609 --------------------------------------GTDS--------------AIKMDGGSF 621

  Fly   845 TWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYV 909
            .|..:.:..  :||.....:.:|:|..:||:.||||:|||.|||.||..|:|::  ....:::||
 Worm   622 AWGSKEEDR--KLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSV--QVNGSVAYV 682

  Fly   910 SQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRI 974
            .|..|:.|.::|.||||...:..|.|..|:|.|||..|:|.:|..|.:.|||:|||:||||:||:
 Worm   683 PQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRV 747

  Fly   975 AIARAIYSSANVVIMDDPLASLDNEVGEHIFQH-------CIREMLQKSNRTFILVTQQLHRIKE 1032
            ::|||:|.:|.:|::||||:::|:.||:|||::       |:      ..:|.:|:|..|..:|.
 Worm   748 SLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCL------GTKTRVLLTHGLTYLKH 806

  Fly  1033 AEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNV 1097
            .:.:|.:||..:...|:|.::
 Worm   807 CDQVIVLKDETISEMGTYQEL-------------------------------------------- 827

  Fly  1098 SKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRK 1162
                        |::|.|.                 |..:||                 |.|:
 Worm   828 ------------MNSNGAF-----------------SEFLEE-----------------FLLE-- 844

  Fly  1163 RSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSI 1227
                                                        .|.|:
 Worm   845 --------------------------------------------ESKHK---------------- 849

  Fly  1228 SGDVLSRSVLATSCSSYAESSVDGGDL------ATAAPEPRVQSWQPPQHVTHHQPLSRNASSPP 1286
                 .|||      |:.|.|.:..:|      .:.|...|:||..
 Worm   850 -----GRSV------SFGEDSKEVNELLRDLDQVSPAIRQRIQSQM------------------- 884

  Fly  1287 AMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSI 1351
            :.|:...|.|.:|..|..                                .|....:|.:||
 Worm   885 SQEIEKTDDKNAEIIRNG--------------------------------LHKDEQTAHSSI--- 914

  Fly  1352 SEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSP 1416
                                   .:||||......|..||.|                      |
 Worm   915 -----------------------GKSEEKESLLGAISPKEKT----------------------P 934

  Fly  1417 ADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITAL 1481
            ...:|...:.:..|               |::|    ||:..::|:.|.||.|:.|..:||:..:
 Worm   935 EPPKQTKTQLIEKE---------------AVET----GKVKFEVYMSYFRAIGIKIALVFFLVYV 980

  Fly  1482 IWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEVTYYFRMYAAI-----SCVC---IIM 1538
            ....|.|:::::|.:||:....:|..|      :....|......:||.:     :.||   |||
 Worm   981 ASSMLGVFSNLYLARWSDDAKEIALSG------NGSSSETQIRLGIYAVLGMGQATSVCAASIIM 1039

  Fly  1539 ALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRL 1603
            ||...       | |.|.||..||:.|:...:.||.|||||||:|||..|:.|||       .||
 Worm  1040 ALGMV-------C-ASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDIDVID-------YRL 1089

  Fly  1604 LQFTLLCLSAILINVTI-------TPW-ILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPV 1660
            ....:..:.||:..|||       ||. ...:|:.:.| ||.:.:||..::|:|:|:|:|:.||:
 Worm  1090 PSCIMTFVGAIVQAVTIFAVPIYATPLSSFPITIVLIG-YYFLLRFYVSTSRQLKRLESASRSPI 1153

  Fly  1661 ISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATV 1725
            .||..|:|||.::|||:....:|......|::.|...|.....::|||.|.|:.:|..||.
 Worm  1154 YSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVL---- 1214

  Fly  1726 TALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWV 1790
             :...|:|..|      .||..||                     .||||:::|.|.:...|||.
 Worm  1215 -SSAGAAVYFR------DSPGLSA---------------------GLVGLSVSYALNITQTLNWA 1251

  Fly  1791 VKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAG 1855
            |::.:::|....:||||..|.                              ::.....:|||.|
 Worm  1252 VRMTSELETNIVAVERINEYT------------------------------ITPTEGNNSQSLA- 1285

  Fly  1856 DKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFH 1920
                                                                             
 Worm  1286 ----------------------------------------------------------------- 1285

  Fly  1921 HPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFD 1985
                                                                |.|||:.|:|...
 Worm  1286 ----------------------------------------------------PKSWPENGEISIK 1298

  Fly  1986 NVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRI 2050
            |.|:||......|:..:|..|...::|||.||||:|||||.|:||.:::...|.|.||..:|..:
 Worm  1299 NFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADL 1363

  Fly  2051 RPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICD 2115
            ..::||:||:|:|||..||:.|:|.||||...|.|.|:|..|..|.|..||.. |..||...|.:
 Worm  1364 LLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKS-LQEGLHHHISE 1427

  Fly  2116 GGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTT 2180
            ||.|||.|.|||:|||||:||.:..||||||.:.:|..|:|.|.|.....|:..|::||||||.|
 Worm  1428 GGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNT 1492

  Fly  2181 ILDYDRLIVLDQGRIVEDGNPRELQQLEGSVF 2212
            ::|.|||:|||:|.:.|...|::|......:|
 Worm  1493 VMDSDRLLVLDKGCVAEFDTPKKLLSNPDGIF 1524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	88/389 (23%)
		TM helix 1	301..324	CDD:350035	7/22 (32%)
		TM helix 2	385..433	CDD:350035	12/47 (26%)
		TM helix 3	480..525	CDD:350035	12/44 (27%)
		TM helix 4	526..575	CDD:350035	12/48 (25%)
		TM helix 5	587..631	CDD:350035	14/50 (28%)
		TM helix 6	648..681	CDD:350035	10/33 (30%)
		ABCC_MRP_domain1	837..1043	CDD:213217	81/212 (38%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	108/351 (31%)
		TM helix 1	1475..1496	CDD:350046	5/20 (25%)
		TM helix 2	1520..1568	CDD:350046	18/55 (33%)
		TM helix 3	1575..1620	CDD:350046	19/44 (43%)
		TM helix 4	1621..1670	CDD:350046	19/49 (39%)
		TM helix 5	1682..1727	CDD:350046	12/44 (27%)
		TM helix 6	1777..1810	CDD:350046	11/32 (34%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	103/220 (47%)
mrp-1	NP_508122.2	MRP_assoc_pro	23..1531	CDD:188098	523/2242 (23%)