DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42366 and SRPK

DIOPT Version :9

Sequence 1:	NP_723501.2	Gene:	CG42366 / 34319	FlyBaseID:	FBgn0259712	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001369087.1	Gene:	SRPK / 36706	FlyBaseID:	FBgn0286813	Length:	1009	Species:	Drosophila melanogaster

Alignment Length:	799	Identity:	162/799 - (20%)
Similarity:	260/799 - (32%)	Gaps:	233/799 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NRYITLTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAMNLREVKSLKKL-----SHPN 61
            :||..:.:||.|.:.||.|.........||||.:|...:..|.|.:  |:|.||.:     |:|.
  Fly   168 DRYHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARD--EIKILKTVRETDPSNPR 230

  Fly    62 IVKLKEVIRE------NDT-LYFVFEYMKENLYQMI-KDRDTHLPEPELKSILFQVLTGLAFMHR 118
            ..|..:::.:      |.| :..|||.:.:||.::| |.....:|...:|:|..|||.||.::|.
  Fly   231 RHKTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKSNYRGIPLANVKTITRQVLEGLDYLHT 295

  Fly   119 -HGFFHRDLKPEN-LLCSG----------------------PDLIKIADFGLAREIRSRPPFTDY 159
             ....|.|:|||| |||..                      |.|:..|    .:|.| .||.|..
  Fly   296 CCKIIHTDIKPENVLLCVDEPHVRSLATEATQLYCMNSKMYPSLVSRA----PKEYR-EPPITGK 355

  Fly   160 VS--------TRWYRAPEVLLHSTNYGSTIDLWAMGCIMAELYTFRPLFPGSSEVDQLFKICSVL 216
            :|        .:..:..|:.....:|....|  ..|.|            ..:||..     ...
  Fly   356 MSKNRKKKLKKKAKKRMELFKQQRDYLEQAD--GQGAI------------NPNEVQN-----GDA 401

  Fly   217 GTPDKDDWPDGYRLASMIHFRYPDCIKVPLSSVVSRCSQNGLDLLEDMLAYDPDKRPTAQQSLKY 281
            |..|.|::.|...:...:|.               ...|......|:..| .|::...||:.
  Fly   402 GISDADEYFDANSVEDNVHV---------------AAGQPSRKQREERKA-PPEQSEEAQEQ--- 447

  Fly   282 PYFHALKRISPTAATKANVRLNSKYAASNGHPVQSVSNNVLPVQEKLQAVTELLHQTNNNMNSHS 346
               ..|...:..|..|...:..:|...|.|.....:.|:....:......::..:.:|:..|:.|
  Fly   448 ---DPLTEGTDKAKKKKKKKNKNKSNQSKGQQPPQLENSTSSAESSSALKSQQANGSNSTTNNKS 509

  Fly   347 NLGKNNNLAPKNGGVPRKYQPKLSFLTTSEMGAGSH----------ADSSSLVGGATVDGVPVPQ 401
            |...:..|..::.|.....:||      .|....:|          ::|.|.:...:|
  Fly   510 NTNSSGTLKGQSNGKKMPLRPK------QEKQGSNHQLNNNNSKPNSNSDSKISSGSV------- 561

  Fly   402 HQNGGESINDIYLNRNISQLFGLPAGPQ--HQQQQ-------QVH--------------HPNVSF 443
             :|...:.|..:.|   |.|...|..||  |:.::       .||              |.....
  Fly   562 -ENTSSATNGPHSN---STLPTPPPPPQAKHKAKKDPALDECNVHVKIADLGNACWVDRHFTEDI 622

  Fly   444 STTSSRNAGAIYVNGSHLSYD---TANMNAKNNAKFVVGASNGGY-YVPVARPS----------- 493
            .|...|:...|...|.:.|.|   ||.|        |...:.|.| :.|.:..|
  Fly   623 QTRQYRSLEVIIGAGYNTSADIWSTACM--------VFELATGDYLFEPHSGESYTRDEDHLAHI 679

  Fly   494 --LLGPDAKVYNVFSKVSASQAPPSLIVRQPQLQPEVAPAPMRLSGRSRAAAAVQDPKM---GAL 553
              ||||                               .|..:.|:|...|.:..:..::   ..|
  Fly   680 IELLGP-------------------------------IPREILLNGTYAAKSFTRSCELRNISGL 713

  Fly   554 KSDDLDLILGSKLKTSAK-----------------RQRNAKANILLEDLFGQLSMDSDSDGKYPH 601
            |...|..:|..|.:.|.|                 .:|...|..|...   .|. |:...|.:..
  Fly   714 KPWGLMDVLLEKYEWSQKDAASFASFLTPMLEFDPNKRATAAECLQHP---WLRXDTMQPGCWLR 775

  Fly   602 -TVPPTQQAKSGKTSTGGHGAGARERDLF---GESYLPRPG------LRKKATQSSL-EVNNGSH 655
             |.|.|.....|..:..|.|.|.|.|...   |...:|..|      :...|:.::| .:::.:.
  Fly   776 ATQPATADGDGGALAGTGTGKGTRARATALKGGSPAVPADGEVGRGYIESSASVATLASISSIAS 840

  Fly   656 ADSLAPNAQKEKPAVASSF 674
            ..:.|..|.|.:|.:.:.|
  Fly   841 TSAAAMAALKARPYLVAPF 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	75/324 (23%)
CG42366	NP_723501.2	S_TKc	4..284	CDD:214567	75/324 (23%)
SRPK	NP_001369087.1	PKc_like	159..>318	CDD:419665	49/151 (32%)
SRPK	NP_001369087.1	PKc_like	<600..763	CDD:419665	35/204 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24055
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100