Protein Alignment CG42366 and CILK1

DIOPT Version :10

• Sequence 1: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: NP_001362326.1
• Gene: CILK1 / 22858
• HGNCID: 21219
• Length: 639
• Species: Homo sapiens
• Alignment Length: 631
• Identity: 257/631 - (40%)
• Similarity: 351/631 - (55%)
• Gaps: 112/631 - (17%)

  Fly     1 MNRYITLTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAMNLREVKSLKKLSHPNIVKL 65
            ||||.|:.||||||||:|:||:..::||.:|||:||||:|||||.||||||||||||:|.|:|||
Human     1 MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANVVKL 65

  Fly    66 KEVIRENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRHGFFHRDLKPEN 130
            ||||||||.|||:||||||||||:||:|:...||..:::|::|:|.||||:|:||||||||||||
Human    66 KEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPEN 130

  Fly   131 LLCSGPDLIKIADFGLAREIRSRPPFTDYVSTRWYRAPEVLLHSTNYGSTIDLWAMGCIMAELYT 195
            |||.||:|:|||||||||||||:||:||||||||||||||||.||||.|.||:||:||||||:||
Human   131 LLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYT 195

  Fly   196 FRPLFPGSSEVDQLFKICSVLGTPDKDDWPDGYRLASMIHFRYPDCIKVPLSSVVSRCSQNGLDL 260
            .||||||:||:|.:||||.|||||.|.|||:||:|:|.::||:|.|:...|.:::...|...:.|
Human   196 LRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCVPNNLKTLIPNASSEAVQL 260

  Fly   261 LEDMLAYDPDKRPTAQQSLKYPYFHA------------------------------LKRISPT-A 294
            |.|||.:||.|||||.|:|:||||..                              :|.:.|. .
Human   261 LRDMLQWDPKKRPTASQALRYPYFQVGHPLGSTTQNLQDSEKPQKGILEKAGPPPYIKPVPPAQP 325

  Fly   295 ATKANVRLNSKYAASNGHPVQ-------SVSNNVLPVQEKLQAVTELLHQTNNNMNSHSNLGKNN 352
            ..|.:.|::|:...::..|:.       .||....|...:....:.||..:.:|.:..|....::
Human   326 PAKPHTRISSRQHQASQPPLHLTYPYKAEVSRTDHPSHLQEDKPSPLLFPSLHNKHPQSVSSPDS 390

  Fly   353 -----NLAPKNGGVPRKYQPKLSFLTTSEMGAGSHADSSSLVGGATVDGVPVPQHQNGG------ 406
                 .|..|||.:..|.:.:...::.|...:...||...|....::..:.:...:...
Human   391 PKITAGLEHKNGEIKPKSRRRWGLISRSTKDSDDWADLDDLDFSPSLSRIDLKNKKRQSDDTLCR 455

  Fly   407 -ESINDI-----------------YLNRNISQLFGLPAGPQHQQQQQVHHPNVSFSTTSSRNAGA 453
             ||:.|:                 |..|:...|  ..|..||..:...:.|.:|.......|.|.
Human   456 FESVLDLKPSEPVGTGNSAPTQTSYQRRDTPTL--RSAAKQHYLKHSRYLPGISIRNGILSNPGK 518

  Fly   454 IYV-------NG-SHLSYDTANMNAKNNAKFVVGASN------GGYYVPVARPSLLG-------- 496
            .::       :| |..|..|.::.:|.|:   ||:|:      .|.|||......:|
Human   519 EFIPPNPWSSSGLSGKSSGTMSVISKVNS---VGSSSTSSSGLTGNYVPSFLKKEIGSAMQRVHL 580

  Fly   497 ---PDAKVYNVFSKVSA-------------SQAPPSLIVRQPQLQP 526
               ||..  ..:|.:.|             .::.|.||.|.|..||
Human   581 APIPDPS--PGYSSLKAMRPHPGRPFFHTQPRSTPGLIPRPPAAQP 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	192/279 (69%)
CILK1	NP_001362326.1	STKc_MAK_like	4..284	CDD:270824	192/279 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..344		5/53 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	464..488		2/23 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	589..639		9/36 (25%)