DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42366 and CILK1

DIOPT Version :9

Sequence 1:	NP_723501.2	Gene:	CG42366 / 34319	FlyBaseID:	FBgn0259712	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001362326.1	Gene:	CILK1 / 22858	HGNCID:	21219	Length:	639	Species:	Homo sapiens

Alignment Length:	631	Identity:	257/631 - (40%)
Similarity:	351/631 - (55%)	Gaps:	112/631 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNRYITLTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAMNLREVKSLKKLSHPNIVKL 65
            ||||.|:.||||||||:|:||:..::||.:|||:||||:|||||.||||||||||||:|.|:|||
Human     1 MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANVVKL 65

  Fly    66 KEVIRENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRHGFFHRDLKPEN 130
            ||||||||.|||:||||||||||:||:|:...||..:::|::|:|.||||:|:||||||||||||
Human    66 KEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPEN 130

  Fly   131 LLCSGPDLIKIADFGLAREIRSRPPFTDYVSTRWYRAPEVLLHSTNYGSTIDLWAMGCIMAELYT 195
            |||.||:|:|||||||||||||:||:||||||||||||||||.||||.|.||:||:||||||:||
Human   131 LLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYT 195

  Fly   196 FRPLFPGSSEVDQLFKICSVLGTPDKDDWPDGYRLASMIHFRYPDCIKVPLSSVVSRCSQNGLDL 260
            .||||||:||:|.:||||.|||||.|.|||:||:|:|.::||:|.|:...|.:::...|...:.|
Human   196 LRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCVPNNLKTLIPNASSEAVQL 260

  Fly   261 LEDMLAYDPDKRPTAQQSLKYPYFHA------------------------------LKRISPT-A 294
            |.|||.:||.|||||.|:|:||||..                              :|.:.|. .
Human   261 LRDMLQWDPKKRPTASQALRYPYFQVGHPLGSTTQNLQDSEKPQKGILEKAGPPPYIKPVPPAQP 325

  Fly   295 ATKANVRLNSKYAASNGHPVQ-------SVSNNVLPVQEKLQAVTELLHQTNNNMNSHSNLGKNN 352
            ..|.:.|::|:...::..|:.       .||....|...:....:.||..:.:|.:..|....::
Human   326 PAKPHTRISSRQHQASQPPLHLTYPYKAEVSRTDHPSHLQEDKPSPLLFPSLHNKHPQSVSSPDS 390

  Fly   353 -----NLAPKNGGVPRKYQPKLSFLTTSEMGAGSHADSSSLVGGATVDGVPVPQHQNGG------ 406
                 .|..|||.:..|.:.:...::.|...:...||...|....::..:.:...:...
Human   391 PKITAGLEHKNGEIKPKSRRRWGLISRSTKDSDDWADLDDLDFSPSLSRIDLKNKKRQSDDTLCR 455

  Fly   407 -ESINDI-----------------YLNRNISQLFGLPAGPQHQQQQQVHHPNVSFSTTSSRNAGA 453
             ||:.|:                 |..|:...|  ..|..||..:...:.|.:|.......|.|.
Human   456 FESVLDLKPSEPVGTGNSAPTQTSYQRRDTPTL--RSAAKQHYLKHSRYLPGISIRNGILSNPGK 518

  Fly   454 IYV-------NG-SHLSYDTANMNAKNNAKFVVGASN------GGYYVPVARPSLLG-------- 496
            .::       :| |..|..|.::.:|.|:   ||:|:      .|.|||......:|
Human   519 EFIPPNPWSSSGLSGKSSGTMSVISKVNS---VGSSSTSSSGLTGNYVPSFLKKEIGSAMQRVHL 580

  Fly   497 ---PDAKVYNVFSKVSA-------------SQAPPSLIVRQPQLQP 526
               ||..  ..:|.:.|             .::.|.||.|.|..||
Human   581 APIPDPS--PGYSSLKAMRPHPGRPFFHTQPRSTPGLIPRPPAAQP 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	192/279 (69%)
CG42366	NP_723501.2	S_TKc	4..284	CDD:214567	192/279 (69%)
CILK1	NP_001362326.1	STKc_MAK_like	4..284	CDD:270824	192/279 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..344		5/53 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..488		2/23 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	589..639		9/36 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	430	1.000	Domainoid score	I596
eggNOG	1	0.900	-	-		E1_KOG0661
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1479
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001823
OrthoInspector	1	1.000	-	-		otm40724
orthoMCL	1	0.900	-	-		OOG6_101384
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3024
SonicParanoid	1	1.000	-	-		X1184
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.750