Protein Alignment nAChRalpha6 and HisCl1

DIOPT Version :8

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Alignment Length: 355
• Identity: 85/356 (24%)
• Similarity: 150/356 (42%)
• Gaps: 53/356 (15%)

  Fly     1 MDSP---LPASLSLFVLLIFLAIIKESCQGPH----------EKRLLNHLLSTYNTLE-RPVANE 51
            |.||   |.....|..|.|:|..:::|.|..|          ...|::|..|:.:..: .|:.::
  Fly     1 MQSPTSKLVEFRCLIALAIYLHALEQSIQHCHCVHGYRNNTESAELVSHYESSLSLPDILPIPSK 65

  Fly    52 S-----------EPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRW--NETEYGGVKD 103
            :           :|..|.|.:|:..:..::|::....|:.:|...|.|..||.  |.:|...:.|
  Fly    66 TYDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILD 130

  Fly   104 LRITPNKLWKPDVLMYNSADEGFDGTYHTNIV------VKHNGSCLYVPPGIFKSTCKIDITWFP 162
            :... :.:|:||....|:...    |:|...:      :.|:.:.||:.......:|.:....:|
  Fly   131 VDWL-HSIWRPDCFFKNAKKV----TFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYP 190

  Fly   163 FDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAMPGKKN-----TIVYACCPE 222
            .|.|.|.|...|.::....|..:.|..|     ..:.|.|..|..:....|     ||.|:  ..
  Fly   191 HDTQICSMMIESLSHTVEDLVFIWNMTD-----PLVVNTEIELPQLDISNNYTTDCTIEYS--TG 248

  Fly   223 PYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDS-GEKLTLGVTILLSLTVFLNLV 286
            .:..:.....:|||..|:.|:..:|..||..|:.:.|.:.|:: ..::|||||.||:|.......
  Fly   249 NFTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQS 313

  Fly   287 AESMPTTSDAVPLIGVTI-LLSLTVFLNLV 315
            .:|:|..| .|..|.|.: ..|:.|||:|:
  Fly   314 QQSLPPVS-YVKAIDVWMSSCSVFVFLSLM 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	81/343 (24%)
		Neur_chan_LBD	30..237	CDD:280998	47/232 (20%)
		Neur_chan_memb	244..511	CDD:280999	25/75 (33%)
HisCl1	NP_731632.1	Neur_chan_LBD	67..262	CDD:280998	42/207 (20%)
		Neur_chan_memb	270..>350	CDD:280999	25/75 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			P	PTHR18945
RoundUp	0	0.000	Not matched by this tool.
	1	1.100