Protein Alignment nAChRalpha6 and lgc-30

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_500015.3
• Gene: lgc-30 / 186551
• WormBaseID: WBGene00019069
• Length: 529
• Species: Caenorhabditis elegans
• Alignment Length: 506
• Identity: 118/506 - (23%)
• Similarity: 209/506 - (41%)
• Gaps: 103/506 - (20%)

  Fly    47 PVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKL 111
            |:.:....::|.....|.||:|:|::|.:.|.:|:|::.|||..::|....:||::.:.:....:
 Worm    82 PLKHPHTRIDVFISAGLYQIVDLDQRNNLATVSAYLDVHWNDDFIKWKPEIFGGIERIFVPIKWI 146

  Fly   112 WKPDVLMYNSA-----DEGFDGT--YHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCE 169
            |||:..||:|.     |...|.:  .|.|.:|:     ::|... .||.|.|:...||||.|.|.
 Worm   147 WKPEFYMYHSVYGRVPDYAPDASAELHYNGLVR-----MFVSIS-SKSFCPINFKRFPFDSQTCS 205

  Fly   170 MKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLL-AMPGKKNTIVYACCPEPYVDITFTIQI 233
            ...|||.|..|.::||...::.. |.||..|.||.|. |......|...:...|.:..:...:.:
 Worm   206 FSCGSWAYQSNIVNLVAAKQEIA-LEDFYDNQEWLLTDARLFNGTTRNVSAANESFSMVYMQLDL 269

  Fly   234 RRRTLYYFFNLIVPCVLISSMALLGFTLPPDS----GEKLTLGVTILLSLTVFLNLVAESMPTTS 294
            :|::.||.|||:.|..|:|.:|::||..|.::    ..|..||:..|||::|.|.::...|....
 Worm   270 KRQSFYYVFNLVFPTTLVSLVAVIGFHAPINATGRRESKFRLGIMTLLSMSVMLLMLVGEMKFAM 334

  Fly   295 DAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFN---CIMFMVASSVVLTVVVLNYHHR 356
            ::||                  ......|| :||:|.|:.   ||:.:...:..:.|.:..:..|
 Worm   335 ESVP------------------GQRGSFSD-VPLMGIYYMTLICIVSIATCTSSIFVHLEKFALR 380

  Fly   357 TADIHEMPPWI-----KSVFLQWLPWILRMGR-----------------PGRKITRKTILLSNRM 399
            ......:|.:|     |.:|..::|...|..:                 |.|.:.:..|     .
 Worm   381 NPSWQSVPWYIRWLAAKKLFCCYVPKSFRYDKDAYSRNNNVQAISLHSTPDRNVAKNLI-----P 440

  Fly   400 KELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLIL 464
            ||:...|.:..:.|.:||:                |.||.                ..:.:.||:
 Worm   441 KEINFTEVNQDAPLHDVLE----------------GPSAE----------------KTQKIDLIV 473

  Fly   465 KELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLL 515
            ..|:.|.....:.....:|...|.   .::.|...:..:.:..:.|:.||:
 Worm   474 SLLREIIHLKERIGASGQLAPYWD---QIISRCEKVSLSFYLFLITINVLM 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	118/506 (23%)
		LGIC_ECD_nAChR	55..236	CDD:349798	55/188 (29%)
		Cys-loop	154..168	CDD:349798	7/13 (54%)
lgc-30	NP_500015.3	Neur_chan_LBD	68..272	CDD:460752	56/196 (29%)
		LGIC_TM_cation	274..>374	CDD:349853	32/118 (27%)
		TM1 helix	274..298	CDD:349853	11/23 (48%)
		TM2 helix	310..338	CDD:349853	8/27 (30%)
		TM3 helix	352..374	CDD:349853	4/21 (19%)