Protein Alignment Pka-C1 and PRKCH

DIOPT Version :10

• Sequence 1: NP_476977.1
• Gene: Pka-C1 / 34284
• FlyBaseID: FBgn0000273
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: XP_047287541.1
• Gene: PRKCH / 5583
• HGNCID: 9403
• Length: 782
• Species: Homo sapiens
• Alignment Length: 341
• Identity: 138/341 - (40%)
• Similarity: 204/341 - (59%)
• Gaps: 9/341 - (2%)

  Fly     2 GNNATTSNKKVDAAETVKEFLEQAKEEFEDKWRRNPTNTAALDDFERIKTLGTGSFGRVMIVQHK 66
            ||.:.|| |.|..:...::..|.:||  .:....|.:|...:|:||.|:.||.||||:||:.:.|
Human   413 GNISPTS-KLVSRSTLRRQGKESSKE--GNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVK 474

  Fly    67 PTKDYYAMKILDKQKVVKLKQVEHTLNEKRILQ-AIQFPFLVSLRYHFKDNSNLYMVLEYVPGGE 130
            .|.|.||:|:|.|..:::...||.|:.|||||. |...|||..|...|:....|:.|:|:|.||:
Human   475 ETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGD 539

  Fly   131 MFSHLRKVGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYLKVTDFGFAKR-- 193
            :..|::|..||.|..:|||||:|:.|..:||...:||||||.:|:|:|.:|:.|:.|||..|.
Human   540 LMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGI 604

  Fly   194 VKG-RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYEKIVSGK 257
            ..| .|.|.||||:|:||||:....|..||||||:|||:|||..|:.||.|:....::|.|::.:
Human   605 CNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDE 669

  Fly   258 VRFPSHFGSDLKDLLRNLLQVDLTKRYGNL-KAGVNDIKNQKWFASTDWIAIFQKKIEAPFIPRC 321
            |.:|:....|...:|::.:..:.|.|.|:| :.|.:.|....:|...||..:..::||.||.||.
Human   670 VVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRI 734

  Fly   322 KGPGDTSNFD-DYEEE 336
            |...|.|||| |:.:|
Human   735 KSREDVSNFDPDFIKE 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C1	NP_476977.1	STKc_PKA	44..333	CDD:271111	125/294 (43%)
PRKCH	XP_047287541.1	C2_PKC_epsilon	8..122	CDD:175981
		C1_nPKC_epsilon-like_rpt1	265..325	CDD:410385
		C1_nPKC_epsilon-like_rpt2	343..397	CDD:410388
		STKc_nPKC_eta	458..780	CDD:270742	123/293 (42%)