Protein Alignment Pka-C1 and PRKCD

DIOPT Version :10

• Sequence 1: NP_476977.1
• Gene: Pka-C1 / 34284
• FlyBaseID: FBgn0000273
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_001341605.1
• Gene: PRKCD / 5580
• HGNCID: 9399
• Length: 695
• Species: Homo sapiens
• Alignment Length: 333
• Identity: 120/333 - (36%)
• Similarity: 190/333 - (57%)
• Gaps: 18/333 - (5%)

  Fly    25 AKEEFEDK-------WRRNPTNTAALDDFERIKTLGTGSFGRVMIVQHKPTKDYYAMKILDKQKV 82
            |.|:.:|.       |  ..::...:::|...|.||.||||:|::.:.|...:|:|:|.|.|..|
Human   342 AGEDMQDNSGTYGKIW--EGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVV 404

  Fly    83 VKLKQVEHTLNEKRILQ-AIQFPFLVSLRYHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHS 146
            :....||.|:.|||:|. |.:.|||..|...|:...:|:.|:|::.||::..|::..|||....:
Human   405 LIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRA 469

  Fly   147 RFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYLKVTDFGFAKR---VKGRTWTLCGTPEYL 208
            .||||:|:...::||...:||||||.:|:|:|..|::|:.|||..|.   .:.|..|.||||:|:
Human   470 TFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYI 534

  Fly   209 APEIILSKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFGSDLKDLLR 273
            ||||:....|..:||||:.|||:|||..|..||..|...:::|.|......:|.....:.||:|.
Human   535 APEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILE 599

  Fly   274 NLLQVDLTKRYGNLKAGVNDIKNQKWFASTDWIAIFQKKIEAPFIPRCKGPGDTSNFD-DYEEEA 337
            .|.:.:.|||.|    ...:||...:|.:.:|..:.::::|.||.|:.|.|.|.|||| ::..|.
Human   600 KLFEREPTKRLG----VTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEK 660

  Fly   338 LRISSTEK 345
            .|:|.::|
Human   661 ARLSYSDK 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C1	NP_476977.1	STKc_PKA	44..333	CDD:271111	112/293 (38%)
PRKCD	NP_001341605.1	C1_nPKC_theta-like_rpt1	171..231	CDD:410384
		C1_nPKC_theta-like_rpt2	250..299	CDD:410387
		STKc_nPKC_delta	372..687	CDD:173710	115/301 (38%)