DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pka-C1 and Lats2

DIOPT Version :10

Sequence 1:NP_476977.1 Gene:Pka-C1 / 34284 FlyBaseID:FBgn0000273 Length:353 Species:Drosophila melanogaster
Sequence 2:NP_056586.2 Gene:Lats2 / 50523 MGIID:1354386 Length:1042 Species:Mus musculus


Alignment Length:388 Identity:126/388 - (32%)
Similarity:192/388 - (49%) Gaps:74/388 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 ETVKEFLEQAKEE------FEDKWRRNPTNTAALDD--FERIKTLGTGSFGRVMIVQHKPTKDYY 72
            |..|..|.:|::|      ::.:...|....|.:|.  |.:|||||.|:||.|.:.....|...|
Mouse   588 EMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKLDTHALY 652

  Fly    73 AMKILDKQKVVKLKQVEHTLNEKRILQAIQFPFLVSLRYHFKDNSNLYMVLEYVPGGEMFSHLRK 137
            |||.|.|:.|:...||.|...|:.||......::|.|.|.|:|..:||.|::|:|||:|.|.|.:
Mouse   653 AMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIR 717

  Fly   138 VGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYLKVTDFGFAKRVKGRTWT-- 200
            :..|.|..:|||.|::.||.|.:|.:..|:||:||:|:|||..|::|:||||..   .|..||  
Mouse   718 MEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLC---TGFRWTHN 779

  Fly   201 ---------------------------------------------------LCGTPEYLAPEIIL 214
                                                               |.|||.|:|||::|
Mouse   780 SKYYQKGNHMRQDSMEPGDLWDDVSNCRCGDRLKTLEQRAQKQHQRCLAHSLVGTPNYIAPEVLL 844

  Fly   215 SKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYEKIVS--GKVRFPS--HFGSDLKDLLRNL 275
            .|||.:..|||::||:::||..|.|||.|..|.:...|:::  ..:..|:  ...::.:||:..|
Mouse   845 RKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWESTLHIPTQVRLSAEARDLITKL 909

  Fly   276 -LQVDLTKRYGNLKAGVNDIKNQKWFASTDWIAIFQKKIEAPFIPRCKGPGDTSNFDDYEEEA 337
             ...|.  |.|  :.|.:|:|...:|.:.|:....:|: .||::|....|.||||||..:||:
Mouse   910 CCAADC--RLG--RDGADDLKAHPFFNTIDFSRDIRKQ-PAPYVPTISHPMDTSNFDPVDEES 967

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pka-C1NP_476977.1 STKc_PKA 44..333 CDD:271111 117/348 (34%)
Lats2NP_056586.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 23..44
Interaction with ubiquitinated AMOTL2. /evidence=ECO:0000250|UniProtKB:Q9NRM7 100..140
UBA_LATS2 100..140 CDD:270581
PHA03247 <150..513 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 237..282
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 378..399
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 442..481
PPxY motif 472..475
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..550
MobB_LATS2 543..625 CDD:439272 8/36 (22%)
Protein Kinases, catalytic domain 624..1004 CDD:473864 118/352 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1014..1042
Blue background indicates that the domain is not in the aligned region.

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