Protein Alignment Pka-C1 and AKT1

DIOPT Version :10

• Sequence 1: NP_476977.1
• Gene: Pka-C1 / 34284
• FlyBaseID: FBgn0000273
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_005154.2
• Gene: AKT1 / 207
• HGNCID: 391
• Length: 480
• Species: Homo sapiens
• Alignment Length: 339
• Identity: 138/339 - (40%)
• Similarity: 204/339 - (60%)
• Gaps: 20/339 - (5%)

  Fly    14 AAETVKEFLEQAKEEFEDKWRRNPTNTA----------------ALDDFERIKTLGTGSFGRVMI 62
            |.:||.:.|::.:||..|....:|::.:                .:::||.:|.||.|:||:|::
Human   102 AIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVIL 166

  Fly    63 VQHKPTKDYYAMKILDKQKVVKLKQVEHTLNEKRILQAIQFPFLVSLRYHFKDNSNLYMVLEYVP 127
            |:.|.|..|||||||.|:.:|...:|.|||.|.|:||..:.|||.:|:|.|:.:..|..|:||..
Human   167 VKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYAN 231

  Fly   128 GGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLH-YLDLIYRDLKPENLLIDSQGYLKVTDFGFA 191
            |||:|.||.:...|||..:|||.|:||.|.:||| ..:::|||||.|||::|..|::|:||||..
Human   232 GGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLC 296

  Fly   192 KR-VK-GRTW-TLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYEKI 253
            |. :| |.|. |.||||||||||::....|.:|||||.|||::|||..|..||:.....:::|.|
Human   297 KEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI 361

  Fly   254 VSGKVRFPSHFGSDLKDLLRNLLQVDLTKRYGNLKAGVNDIKNQKWFASTDWIAIFQKKIEAPFI 318
            :..::|||...|.:.|.||..||:.|..:|.|.......:|...::||...|..:::||:..||.
Human   362 LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFK 426

  Fly   319 PRCKGPGDTSNFDD 332
            |:.....||..||:
Human   427 PQVTSETDTRYFDE 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C1	NP_476977.1	STKc_PKA	44..333	CDD:271111	130/293 (44%)
AKT1	NP_005154.2	PH_PKB	4..111	CDD:269947	3/8 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..138		4/24 (17%)
		STKc_PKB_alpha	124..479	CDD:270746	131/317 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	450..480