DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pka-C1 and Pkn2

DIOPT Version :10

Sequence 1:NP_476977.1 Gene:Pka-C1 / 34284 FlyBaseID:FBgn0000273 Length:353 Species:Drosophila melanogaster
Sequence 2:NP_848769.2 Gene:Pkn2 / 109333 MGIID:109211 Length:983 Species:Mus musculus


Alignment Length:317 Identity:126/317 - (39%)
Similarity:192/317 - (60%) Gaps:9/317 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 EFEDKWRRNPTNTAALDDFERIKTLGTGSFGRVMIVQHKPTKDYYAMKILDKQKVVKLKQVEHTL 92
            |.:|| |.......:|.||.....||.|.||:|::.::|.|.:.:|:|.|.|..:|...:|:..:
Mouse   639 ELDDK-RAQQRFQFSLQDFRCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEVDSLM 702

  Fly    93 NEKRILQ---AIQFPFLVSLRYHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAAQIV 154
            .||||.:   :::.||||:|...|:...::..|:||..||::..|:. ...||||.:.||||.:|
Mouse   703 CEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH-TDVFSEPRAVFYAACVV 766

  Fly   155 LAFEYLHYLDLIYRDLKPENLLIDSQGYLKVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSK 216
            |..:|||...::|||||.:|||:|::|::|:.|||..|...|   ||.|.|||||:||||::...
Mouse   767 LGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTET 831

  Fly   217 GYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFGSDLKDLLRNLLQVDLT 281
            .|.:|||||.||||:|||..|..||..|...::::.||:.:||:|....::...::|.||:.:..
Mouse   832 SYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPE 896

  Fly   282 KRYGNLKAGVNDIKNQKWFASTDWIAIFQKKIEAPFIPRCKGPGDTSNFDD-YEEEA 337
            :|.|..:....|:|...:|..|||.|:..||::.||:|..:|..|.||||| :..||
Mouse   897 RRLGAGEKDAEDVKKHPFFRLTDWSALMDKKVKPPFVPTIRGREDVSNFDDEFTSEA 953

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pka-C1NP_476977.1 STKc_PKA 44..333 CDD:271111 119/295 (40%)
Pkn2NP_848769.2 HR1_PKN_1 42..107 CDD:212012
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 107..135
HR1_PKN2_2 128..201 CDD:212021
HR1_PKN2_3 209..282 CDD:212025
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 351..382
Necessary to rescue apical junction formation 381..462
C2_PKN-like 389..472 CDD:176069
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 553..588
STKc_PKN 656..981 CDD:270741 120/299 (40%)
Necessary for the catalytic activity. /evidence=ECO:0000250 916..976 18/38 (47%)
Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA. /evidence=ECO:0000250 977..983
Blue background indicates that the domain is not in the aligned region.

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