DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Apoltp and vtg3

DIOPT Version :9

Sequence 1:	NP_995670.2	Gene:	Apoltp / 34283	FlyBaseID:	FBgn0032136	Length:	4333	Species:	Drosophila melanogaster
Sequence 2:	NP_571340.1	Gene:	vtg3 / 30518	ZFINID:	ZDB-GENE-991019-2	Length:	1253	Species:	Danio rerio

Alignment Length:	1277	Identity:	247/1277 - (19%)
Similarity:	448/1277 - (35%)	Gaps:	377/1277 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 YKYQYTVAVRTEFAGSGDNSSDLLLKSDLEIFFPKPCEGYLRINDAKLYDTLDELNDNESDSSEK 116
            |||:..|.|..|.....:  |.|.|:...:|....|....|::::.
Zfish    32 YKYEGLVQVGRELPHLVE--SALKLRCTFKIIGESPHTFVLQVSNV------------------- 75

  Fly   117 TKEYDYYDNLANEE--SESQNYDNMHPKSSDFNVDLTKNL-------LRFAFHDGLISEVCPQEQ 172
              :::.::.:..:.  |.|:|              :||:|       :.|.:..|.|:::.....
Zfish    76 --DFEDFNGIPGKSVFSPSKN--------------ITKHLSAEISQPIIFEYSKGQITDIRTAPG 124

  Fly   173 ETPWVLNIKKGILSAFQNTMMRFDVDANTTETDVSGQCQVQYAL-EDTDSSYVTIRKTKDINSCR 236
            .:..|:||.:|||...|.|:..........|..:.|.||..|.: ||:::..:.:.:..||.:|:
Zfish   125 VSNTVVNIVRGILGFLQVTVKTTQSFYELIELGIHGLCQSSYTVDEDSNAKELIVTRIVDITNCQ 189

  Fly   237 Q-----------------RYATHSVLQTTPYTFRDDKTIWPILKSQSHCNLTIDNNVYKEIKCLE 284
            |                 :....||:.|..:|:        .:||      |.|.....:....|
Zfish   190 QPASLYRGMALAPEDKLSKQRGESVVSTVKHTY--------TVKS------TADGGQITKAFAQE 240

  Fly   285 THLLVPFSNASSGALTTSTSR----LKL-DGVESYSAGEFLEQNPELVERRATLVFDHTPAVKP- 343
            .....|| |...|.......|    ||: |..:....|:        |:.|..|::.....:||
Zfish   241 RQYFSPF-NVKGGNFRMLALRDIELLKVSDTTDKVVTGQ--------VQSRGNLMYKTNKDLKPI 296

  Fly   344 ------SHDEIKAARELLVEMCRVGFPNIQREFIDVFTNFLQTSKSLDYKTLSVL--LQRSASTC 400
                  .:|.:....:|:..:.:....::..|   ..|..|...:.:...||..|  |.:..|..
Zfish   297 PVVMLNLNDPVPKILDLIKRLAQANIYHVDSE---TSTEILDLIQLMRVTTLDNLEHLWKQVSGN 358

  Fly   401 EQGRNHLLE---------SLPFIGSTASYK--------------VMRDQIINEKLTKQMAHDWMT 442
            ::.|...|:         .|.|:  .|.||              |..:.:..|.::..:|.:
Zfish   359 DEHRRWFLDLVVEVTDERILKFL--EARYKAGDITANEAGQALVVAFNHLSAEPVSVALAQE--- 418

  Fly   443 ALSFITRPDEETLETFHSILEYAKNRLDAEYTLGATAVVHSFCKHHEACEENLRVQQIINLLETE 507
               |:|.|..::    |.:|...       ..|...::||.:|.:.:.|...: ||.::|:..:.
Zfish   419 ---FLTIPFSKS----HPLLWNT-------VVLAYGSLVHRYCVYTDPCPITV-VQPLLNMAASS 468

  Fly   508 FLNLYNLFKGERRTRERMVILLKGLGNIGVVSSAFAEQLQWI--IREDEAPVDIRLHG--ILAFR 568
            .         .:.:.:.||:.||.|||...:|| |...|:::  .......:..|:.|  :.|||
Zfish   469 L---------SKNSEDEMVLALKSLGNAAHLSS-FKTLLKFLPGYSNGAEKLSTRVQGAAVQAFR 523

  Fly   569 RV-DCARH--RSYFLDNYGNYTLNSELRIYSYLQAMRC-PDYISVGVIKSILEHEEINQVGSFVW 629
            .: ..|.|  :...|:.:....|.:|:|:.:.:..:.. |....:.|:..:|..|...||.||.:
Zfish   524 LLASRASHSVQDIVLNLFVQKHLPAEIRMLACIVLLETKPSTALISVVSEVLLEEADLQVASFSY 588

  Fly   630 SHLTNLAKSNSPVRIEAQGLLLNDELSERFKMDIRK-------FSRNYEHSLFFDEYNFGTTTDA 687
            |.|...|||.:|   :.|.|.:...::  .|:..||       :|:|.....|.|::.|||:.|.
Zfish   589 SLLKGFAKSRTP---DNQHLSIACNIA--MKILTRKLGHLSYRYSKNLHFDWFHDDFLFGTSADV 648

  Fly   688 NVIFGTDSYLPRIASVNFTADLFGQSVNFFEFTARAEGLEELAANAFGPKGPLSGQLLRKKLSFL 752
            .:: ..:|.:|....:.......|:.:.|.||..||:||::|.|.               |:..|
Zfish   649 YML-QNESPIPTKLMLKGKFHFIGRILQFLEFGIRADGLKDLFAG---------------KIPEL 697

  Fly   753 NRWLGNESAEEDDTLENLLSLDNLRLKRKAQEQARASEEEVDEDYDFEESLEGNKRQKRDVSTTR 817
            .:.||         :.:|.|:    ||..:..|:...::.:...|
Zfish   698 TKDLG---------ISDLASI----LKILSNWQSLPKDKPLLTAY-------------------- 729

  Fly   818 KQEIDRNVDSLGYKLKYDYNNPRAQFGLRVFGNDLRYFNVESLVEVMALAAKFNP--------FQ 874
                                       .||||.:....:| |...|.::...|:|        ::
Zfish   730 ---------------------------ARVFGQEAFLMDV-SRDSVQSIIKSFSPSAGKESKVWE 766

  Fly   875 QAKNVLSGKEFTYTKSRVFLDASYTVPLAVGLPLAIHAFGA--SSIDLRVSGNLDEMDPPTDWHF 937
            :.::|..|..:.:||..:..:|.:..|..:|||:.|..:.:  :::.::...   |::||...|.
Zfish   767 RIQDVQKGTSWHWTKPHLVYEARFIQPTCLGLPVEISKYYSVVNAVTMKAKA---EINPPPKEHL 828

  Fly   938 ------DVEGQFKPSVSVD----VITTMQTDMFWEQSGIKVKSNLYSNSELVAKLKVRGRNLVSF 992
                  |:..|....:.|.    :...:.||:|  |.|.::||.:.........||:..:. .::
Zfish   829 GELLSSDISMQTDGFIGVTKDHFLFHGINTDLF--QCGTELKSKVSMGLPWAFDLKINPKE-QTY 890

  Fly   993 SFDLPRDKN--EIFSVRS---------------------------------ELLVQKREEQLPQA 1022
            ..:|...|:  |:|||.|                                 .:|...|:||..::
Zfish   891 EMNLTPSKSVTELFSVSSNVYAVLRNIEDPTSSKITPMMPETGESWQGVPLRMLPPLRDEQTKKS 955

  Fly  1023 GIANRSANSTCTWPVLDQAIGLQMC-------SHYSVPDLSNATEIYPSLLLAGPLNFSLILKKS 1080
            |:..|.....       :..|..:|       :||        ...||...|.|..:||..|:.:
Zfish   956 GMKFRQCAEA-------KIYGTALCIEAEAKRAHY--------LHEYPLYYLLGDTHFSYSLEPA 1005

  Fly  1081 -----------DLSAKKY--------------VFEYKWDQQEEDNNFSLVFTTPGSKVPRVLVAN 1120
                       .:||.:.              ||     ::..|.|.|.......|.:|.....:
Zfish  1006 KDAKPIEKIQIQVSASRQHPSVMSGMVNLNQRVF-----KETRDENTSCEERKTSSSLPVTQDLD 1065

  Fly  1121 VTKVPDAFNASVAFVNGPNRVSAGCSYDGNPDFRRLDIYLDT 1162
            ||  ||......|....|.....|  |:|      :..||.|
Zfish  1066 VT--PDPVVTVKALSLSPQAKPLG--YEG------VAFYLPT 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Apoltp	NP_995670.2	LPD_N	49..633	CDD:214755	127/652 (19%)
		DUF1943	665..1012	CDD:286281	73/408 (18%)
		DUF1081	1029..1122	CDD:283982	20/124 (16%)
		VWD	3741..3908	CDD:295339
		C8	3951..4014	CDD:285899
vtg3	NP_571340.1	Vitellogenin_N	24..592	CDD:279663	127/652 (19%)
		DUF1943	626..912	CDD:286281	72/368 (20%)
		DUF1944	1070..1238	CDD:286284	8/36 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9069
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.010