Protein Alignment Apoltp and vit-1

DIOPT Version :10

• Sequence 1: NP_995670.2
• Gene: Apoltp / 34283
• FlyBaseID: FBgn0032136
• Length: 4333
• Species: Drosophila melanogaster
• Sequence 2: NP_001367671.1
• Gene: vit-1 / 181034
• WormBaseID: WBGene00006925
• Length: 1616
• Species: Caenorhabditis elegans
• Alignment Length: 1861
• Identity: 344/1861 - (18%)
• Similarity: 634/1861 - (34%)
• Gaps: 611/1861 - (32%)

  Fly   128 NEESESQNYDNMHPKSSDFNVDLTKNLLRFAFHDGLISEVCPQEQETPWVLNIKKGILS--AFQN 190
            :|:..|.|.......|.::. .:.|..||....:|||:|:...:::..|..|:|:.:::  :|..
 Worm    85 SEQIPSLNSMEQRELSEEYK-QMLKLPLRAQLRNGLIAELQFDKEDAEWSKNMKRAVVNMISFNP 148

  Fly   191 TMMRFDV-------------DANTT----ETDVSGQCQVQYALEDTDSSYVTIRK------TKDI 232
            ...|.::             :.||:    |..:.|.|||         :|..||:      ||.|
 Worm   149 IAPRNEIEKIESSYDKEEQSEENTSFFTNEKTLEGDCQV---------AYTVIREQKKTIITKSI 204

  Fly   233 N--SCRQR----YATHSVLQTTPYTFRDDKTIWPILKSQSHCNLTIDNNVYKEIKCLETHLLVPF 291
            |  .|.:|    |.                     |:..|.|.....:.|....:.:.|::|
 Worm   205 NFDKCTERSEIAYG---------------------LRYSSECPECEKDTVLIRPQTVYTYIL--- 245

  Fly   292 SNASSGALTTSTSRLKLDGVESYSAGEFLEQNPELVERRATLVFDHTPAVKPSHDEIKAARELLV 356
                      ....||...|.|........|.....|.|:.||.:...::|...:::...:|.::
 Worm   246 ----------ENEELKESEVRSLYTVNVNGQEVMKTETRSKLVLEENHSIKSHIEKVNGEKESII 300

  Fly   357 ------EMCRVGFPNIQREFIDVFTNFLQTSKSLDYKTLSVLLQ--------------------R 395
                  ::....|.|..:.....|..|....|....||::..:|                    |
 Worm   301 YSSRWEQLVEDFFKNGDKAEFAPFEKFPLDKKMHLIKTITEQIQEVENNIPETSHFLARLVRIFR 365

  Fly   396 SASTCEQGRNH-------------LLE-SLPFIGSTASYKVMRDQIINEKLTKQMAHDWMTALSF 446
            :.||.:....|             |:| :|...|:..:.:.:...|.||.:....|...:.::..
 Worm   366 TTSTSQLKEIHETLYVKADKKIQSLMEHALAIAGTKNTIQHILVHIENEDIVPLEAAQLLKSIQE 430

  Fly   447 ITRPDEETLETFHSILEYAKNRLDAEYT-------LGATAVVHSFCKHHEACEENLR--VQQIIN 502
            ...|.:...|   :::::|::|:.....       |.|.:||.....:     :|:|  |::...
 Worm   431 TPFPSQTIAE---ALIKFAESRVSKNNQVVRQSAWLAAGSVVRGIVDY-----KNIRPLVREDKR 487

  Fly   503 LLETEFLNLY-NLFKGERRTRERMVILLKGLGNIGVVSSAFAEQLQWIIREDEAPVDIRLHGILA 566
            .|:.:||.:: ..:|....|.|: ::.||.:||.|:..|  ..||..||.:....:.:|...|.|
 Worm   488 ELKEKFLRVFMQQYKDAETTYEK-ILALKSIGNAGLDIS--VNQLNEIIVDKRQLLPVRKEAIDA 549

  Fly   567 FRRVDCARHR---SYFLDNYGNYTLNSELRIYSYLQAM--RCPDYISVGVIKSILEHEEINQVGS 626
            .|.:.....|   ...|..|.|.....|:|:.:..:.|  |..:.:.|.|: |.:|.|...||.:
 Worm   550 LRLLKDTMPRKIQKVLLPIYKNRQYEPEIRMLALWRMMHTRPEESLLVQVV-SQMEKETNQQVAA 613

  Fly   627 FVWSHLTNLAKSNSPVRIEAQGLLLNDELS-ERFKMDIRKFSRNYEHSLFFDEYNF-GTTTDANV 689
            .....:.:.|||.:|. .:...::.:..|| .|::...:..:.:|.....|.:.:| |...|...
 Worm   614 LTHQMIRHFAKSTNPC-YQRVAIVCSKVLSFTRYQPQEQMIASSYAQLPLFLQNSFSGAQFDFAA 677

  Fly   690 IFGTDSYLPRIASVNFTADLFGQSVN--FFEFTARAEGLEELAANAFGPKGPLSGQLLRKKLSFL 752
            ||..:|:|.:....:..| :||.:.|  |.:.....:.:::..            |:..:||
 Worm   678 IFEKNSFLLKDLHASLDA-VFGGNWNKYFAQIGFSQQHMDKYV------------QMALEKL--- 726

  Fly   753 NRWLGNESAEEDDTL--------ENLLSLDNLRLKRKAQEQARASEEEVDEDYDFEESLEGNKRQ 809
                  ||.|::.|.        ..:..|..|.||...  :||.:      :|        |::.
 Worm   727 ------ESIEKESTTVVRGRRIQTGITLLKELALKMNI--RARPA------NY--------NEKD 769

  Fly   810 KRDVSTTRKQEIDRNVDSLGYKLKYDYNNPRAQFGLRVFGNDLRYFNVESLVEVMALAAKFNPFQ 874
            ...:...|.:::|..:..:..:|                        :|.|:|......|.. |.
 Worm   770 AFAMVYLRYKDMDYAILPVDTQL------------------------IEKLIEKYISNGKVQ-FS 809

  Fly   875 QAKNVLSGK-EFTYTKSRVFLDASYTVPLAVGLPLAIHAFGASSIDLRVSGNLDEMDPPTDWHFD 938
            :.:.:|:.: ||....:..|.:|....|..:||||.            |||.:     ||  .|.
 Worm   810 EIRRLLNQEHEFETHHAAYFYEAIRKFPTTLGLPLI------------VSGKI-----PT--VFS 855

  Fly   939 VEGQF---------------KPSVSVDVITTMQ--TDMFWEQSGIK-VKS-NLYSNSELVAKLKV 984
            .||||               :|||:...:..|:  |.:|  :.|:| |:| ..|:..::.|.:.:
 Worm   856 AEGQFSLGLEETELRLTVEARPSVAATHVYEMRMFTPLF--EQGVKSVQSVRAYTPIKIQAVVGM 918

  Fly   985 RGRNLVSFSFDLPRDKNEIFSVRSELLV---------------QKREEQLPQAGIANRSANSTCT 1034
            :....:.:...:|.::..|.|:.:..:|               ::|...:||
 Worm   919 KRNFEIVYKVVVPENQKSIISLTTRPVVFLRFPGFSKFEYIEAEERTVVVPQ------------- 970

  Fly  1035 WPVLDQAI-------GLQMCSHYSVPDLSNATEIYPSLLLA------------GPLNFSL----- 1075
            |....|.|       ||::.:..::  |:..|  ..:.|||            .|..|:.
 Worm   971 WQQKTQEIEKVFNFLGLEVSTRGNI--LNQHT--LENWLLAEQDFEVSVENKYRPAEFTARLTVG 1031

  Fly  1076 ILKKSDLSAKKY--VFEYKWDQQEEDNNFSLVFTTPGSKVPRVLVANVTKVPDAFNASVAFVNGP 1138
            .|:|::||..||  :||.:::.::|:......:.|.       :|.::.| ...:.:.|:.
 Worm  1032 QLEKTELSQIKYNKIFEKEFELEQENTESRREYFTK-------MVKSIQK-EQGYKSVVSL---- 1084

  Fly  1139 NRVSAGCSYDGNPDFRRL-DIYLDTNGNRSLDLGMELRRH---QDFTAWIYNPRMLLAINGVNIT 1199
             |:.|...|..|.:...: |..:     |.....:|:||.   ::...|....::|:
 Worm  1085 -RLEAPRDYTMNTEVTTVCDKQV-----RMCQWEVEIRRSPILEETKEWTLRSQLLV-------- 1135

  Fly  1200 GLAGTVKVNEKNGIKQ-HD-----VDLSFETKKLQAVIKGNVVQSEITTSTNMTIKYRFQANKIE 1258
                 |:....:.::| ||     |.||..:      ..|:..:||:|.:..:
 Worm  1136 -----VRPEMPSSLRQLHDQPHREVQLSLTS------TWGSQKKSEVTVNAQL------------ 1177

  Fly  1259 EINFAGKLVNNGDKSKTEYRGNMKLQTSAYPKLNFASESTWLSLQGHTEGMITYNNAPDYVNPNY 1323
                      ...|.:.:|..||                     ..|..||           |.|
 Worm  1178 ----------QQSKEQKKYERNM---------------------DRHFNGM-----------PEY 1200

  Fly  1324 TSLVRLIFARSHSEDSFLDGTQTRASLELKLPRSKIDYRILVKHKEHIK------------NGTE 1376
            ..|::.  ||.:         |..|..|.||.|.  ..::|.::.:.:|            |...
 Worm  1201 ELLIKA--ARLN---------QINAVAEYKLTRE--TEQVLARYFDLVKAYNYWTVSSRPENNEN 1252

  Fly  1377 HNVIVGLKYTPEK------------EITGLFSVHLPRRNLFAIDAYMNV--TVPEFNSCTASLKV 1427
            ..|:|.|...|..            |...|.:|.:||..|.:| |..:|  .:.|.:.....::.
 Worm  1253 DRVVVQLTVEPMSRQYVNITMQSPIERVELKNVQVPRVYLPSI-AQRSVKHLLNEASGSVCKVQK 1316

  Fly  1428 NEKATKDYIIFINGSWFTGHSVAVKANYKDRSSRVQALHHLKMIVESPSFNITSLNIIYRRKQLL 1492
            |:..|.|.::: |....|.:|:..    ||.|             |.|:|.:.|.......::::
 Worm  1317 NQIRTFDDVLY-NTPLTTCYSLIA----KDCS-------------EEPTFAVLSKKTEKNSEEMI 1363

  Fly  1493 IFYDIQAKYDQDPYGLTIQYASNAHNRNTNAEVRLKVKERDYWINAKLLSEQPKLLQLEIHMDKI 1557
            |      |..:....:..|.        .|.|:|:||..:      |:|||.....|:|
 Worm  1364 I------KVIRGEQEIVAQL--------QNEEIRVKVDGK------KILSEDYSAHQIE------ 1402

  Fly  1558 RDVHIQVGLLNVDKRKELSLELKWDANRDPSQRLGLLAEYNSPGTKHYDGNLMITYPERTIHFGF 1622
                                            |||             :.:::|..||..:.|
 Worm  1403 --------------------------------RLG-------------ESDIVIELPEGEVRF-- 1420

  Fly  1623 NSFTGGPKYFGKVHASWSINEVIEFEYEAGILPGHTLHNWVKAELRTPFDGWRVNSLDAGIYSLK 1687
                                            .|:|    :|.:|.:              ||.|
 Worm  1421 --------------------------------DGYT----IKTQLPS--------------YSRK 1435

  Fly  1688 NLI--LVNSTLFWADDQKLQVGYKSDYDVNDQLMSFDVRFGINSTIRDIPTINVKVKHWMDVKKV 1750
            |.:  |..:.    ||:.....|.||......:..|...:.:.:  .:......::....:.:|.
 Worm  1436 NQLCGLCGNN----DDESTNEFYTSDNTETKDIEEFHRSYLLKN--EECEAEEERLSEKKNYRKY 1494

  Fly  1751 DTELYLG--YSGQNDTFNTYSMDSSWEIEKNQRYNNYSGLV 1789
            |...|..  ||.: :|:: |..:::.:.:||||....|.||
 Worm  1495 DERKYESEEYSFE-ETYD-YEQENTNKKQKNQRSQKKSDLV 1533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Apoltp	NP_995670.2	LPD_N	49..633	CDD:214755	116/590 (20%)
		Vit_open_b-sht	665..1005	CDD:462702	71/370 (19%)
		DUF1081	1027..>1116	CDD:461916	22/114 (19%)
		VWD	3741..3908	CDD:214566
		C8	3952..4014	CDD:214843
vit-1	NP_001367671.1	Vitellogenin_N	24..620	CDD:460170	116/590 (20%)
		Vit_open_b-sht	655..939	CDD:462702	71/367 (19%)
		VWD	1301..1458	CDD:214566	48/301 (16%)