DRSC/TRiP Functional Genomics Resources

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Protein Alignment Apoltp and apobb.2

DIOPT Version :10

Sequence 1:NP_995670.2 Gene:Apoltp / 34283 FlyBaseID:FBgn0032136 Length:4333 Species:Drosophila melanogaster
Sequence 2:XP_002665852.3 Gene:apobb.2 / 100330435 ZFINID:ZDB-GENE-070705-554 Length:2633 Species:Danio rerio


Alignment Length:3319 Identity:652/3319 - (19%)
Similarity:1137/3319 - (34%) Gaps:1049/3319 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGGLKPQAAIWLLLLIAHTQAVRENPLKDPRICGRPQCDSKSAKFNYGEQLYKYQYTVAVRTEFA 65
            ||..|.:..::..|:|.             .||.|.:..||...|...|.|......|       
Zfish     1 MGDHKLRLLLFFSLIIL-------------SICRRFKPLSKHEYFYETESLNSLNKQV------- 45

  Fly    66 GSGDNSSDLLLKSDLEIFFPKPCEGYLRINDAKLYDTLDELNDNESDSSEKTKEYDYYDNLANEE 130
             :|..:|     ..:||..|...:..||..|.||              ||.|.          .:
Zfish    46 -NGPKAS-----CRVEILVPDASKYILRTTDCKL--------------SEVTA----------VD 80

  Fly   131 SESQNYDNMHPKSSDFNVDLTKNLLRFAFHDGLISEVCPQEQETPWVLNIKKGILSAFQNTMMRF 195
            :|..........:.||..|:.||.|:|....|.| .:.|::.|...:||||:||:||....::..
Zfish    81 TEGNPVFGKAAAAEDFRTDMEKNPLKFTVTKGEI-RLFPEKGERANILNIKRGIISALAVPLLEE 144

  Fly   196 DVDANTTETDVSGQCQVQYALEDTDSSYVTIRKTKDINSCRQRYATHSVLQTTPYTFR--DDKT- 257
            |...||  ..:.|.|..:|.: || ::.||:  .:|::.|.:              ||  :|.| 
Zfish   145 DRKKNT--PSIYGLCMTEYTV-DT-ATAVTL--NRDLSRCDK--------------FRPIEDHTS 189

  Fly   258 -----------IWPILKSQSHCNLTIDNNVYKEIK------CLETHLLVPFSNASS-GALTTSTS 304
                       :..:::|...||...|    ||.:      |.|.|:|||||:... |...|...
Zfish   190 PLALITGLSHPLAQLIRSNQTCNYKFD----KEQEHMTSAICTEKHVLVPFSHKGEYGVTNTGKQ 250

  Fly   305 RLKLDGVESYSAGEFLEQNPELVERRATLVFDHTPA-VKPSH----------DEIKAARELLVEM 358
            .|.|.||        .|.|..        ||||..| :||.|          .:.:||..:|   
Zfish   251 VLTLLGV--------TENNDR--------VFDHNIANMKPLHLDRSVDISPVQDKEAALAVL--- 296

  Fly   359 CRVGFPNIQREFIDVF-TNFLQTSKSLDYKTLSVLLQRSASTCEQGRNHLLESLPFIGSTASYKV 422
                     ||..|:: ||..:....|.||.::|:.:..|.|.   |..|.|:|. |..:.:|:.
Zfish   297 ---------RELADLYKTNSGRKRAHLAYKLVAVIRKMEAETL---RAALPEALG-ISRSLTYQA 348

  Fly   423 MRD-----------QII-----------------------NEKLTKQMAHDWMTALSFITRPDEE 453
            :..           |||                       ::.|.|:|.   .||....:||   
Zfish   349 LLQCGTPKCSSAIMQIIRTFDKSSFEVDAAVYAIGIIPQTSQVLVKEML---ATAKIKPSRP--- 407

  Fly   454 TLETFHSILEYAKNRLDAEY-TLGATAVVHSFCKHHEACEENLRVQQIINLLETEFLNLYNLFKG 517
                .:..|..|..||   | |.|.|:.:.:...:        .::||                |
Zfish   408 ----IYYALSNAVRRL---YETDGVTSEIQAVADY--------ALEQI----------------G 441

  Fly   518 E-RRTRERMVILLKGLGN----IGVVSSAFAEQLQWIIREDEAPVDIRLHGILAFRRVDCARH-R 576
            : ...:|.:.:.||.:||    :|....|....:...|.:..|...::...|..:|:...... |
Zfish   442 DCTGDQEHVFLSLKVIGNMVAALGAARPALHSAVIKCINQPGASPAVQQAAIQVYRQFPVPEEGR 506

  Fly   577 SYFLDNYGNYTLNSELRIYSYLQAMRCPDYISVGVIKSILEHEEINQVGSFVWSHLTNLAKSNSP 641
            ...:....:...:.:.|:.:||..|:.|....:..:.:.||.|:.::..||:.||::::..|.:|
Zfish   507 EVLMHTVLDKVASVQKRVAAYLILMKNPTPAELAQLAAALEIEKNHEAKSFIISHISSIMASTAP 571

  Fly   642 VRIEAQGLLLNDELSERFK-------MDIRKFSRNYEHSLFFDEYNFGTTTDANVIFGTDSYLPR 699
                 :.|.|...:...|:       |...:|||:|...          :.:.|.||.:...|||
Zfish   572 -----ETLNLRQNIQNAFQGNDIEMAMKSTQFSRHYRLG----------SLEGNFIFESPDNLPR 621

  Fly   700 IASVNFTADLFGQSVNFFEFTARAEGLEELAANAFGPKGPLSGQLLRKKLSFLNRWLGNESAEED 764
            ...:..|.:.||..::..|.....:|.|.:....||..|.....:::..|...::.    .||.:
Zfish   622 EVMLEMTLNAFGLDMDLIEIGMEGKGFEPILEALFGEDGFFPDIVMKSILYATDKM----PAELN 682

  Fly   765 DTLENLL-SLDNLRLKRKAQEQARASEEEVDEDYDFEESLEGNKRQKRDVSTTRKQEIDRNVDSL 828
            :..:|:| :|:|.|.||:|.:..                               .:||..:|:.|
Zfish   683 EVWDNMLPNLNNYRKKRQATQNI-------------------------------VKEISDSVNKL 716

  Fly   829 GYKLKYDYNNPRAQFGLRVFGNDLRYFNVESLVEVMALAAKFNPFQQAKNVLSGKEFTYTKSRVF 893
            ...||.. :.|.|...|::.|.:|.|.:.:. .:::....|..|....|.:.|..:.......:|
Zfish   717 SEDLKAQ-DAPEAMVYLKLLGAELGYLDAKD-GKMIGSLLKMIPTDFTKRLFSSVDNELFLHYIF 779

  Fly   894 LDASYTVPLAVGLPLAIHAFGASSIDLRVSGNLDEMDPPTDWHFDVEGQFKPSVSVDVITTMQTD 958
            :|..:.:|.|.|.||.:...|..:..::  |.|.......|:.|.:      |..|:::|.:.|.
Zfish   780 MDNEFYLPTAAGFPLRVALSGTFTPGIK--GGLSFNPGMGDFAFML------SAGVELVTEIGTH 836

  Fly   959 M-FWEQSGIKVKSNLYSNSELVAKLKVRGRNLVSFSFDLPRDKNEIFSVRSELLVQKREEQLP-Q 1021
            : .:..||:::.:|:|..|.|.||:....:.| ..|...||:..|:.||.:.|:.....:.|| .
Zfish   837 LPDYVHSGLEMHTNIYHESGLRAKISGTQKRL-KLSIPAPREPTELISVTNSLVSVVGGKILPIS 900

  Fly  1022 AGIANRSANSTCTWPVLDQAIGLQMCSHYSVPD--LSNATEIYPSLLLAGPLNFSLILKKSDLSA 1084
            |.:.....:.|..:|      ||:.|:....||  |::....:|   |.|...|::.::.|. :.
Zfish   901 ANVQYTMEDCTAVFP------GLKSCTTLEYPDAALNDNAPYFP---LTGDSRFAVEIRPSG-TV 955

  Fly  1085 KKY--VFEYKWDQQEEDNNFSL-VFTTPGSKVPRVLVANVTKVPDAFNASVAFVNGPNRVSAGCS 1146
            .:|  :..|.::.:|:...||: ...||...:..|::                    ||.....|
Zfish   956 TEYTAIIGYTYEDEEDKLTFSVKAEGTPFEVLNTVMI--------------------NRKLNTAS 1000

  Fly  1147 YDGNPDFRRLDIYLD---TNGNR-SLDLGMELRRHQDFTAWIYNPRMLLAINGVNITGLAGTVKV 1207
            .....:..:||..:.   ||..: .|:|..:|:                         |.||..|
Zfish  1001 MKLLMEALQLDHTVSGKFTNAEKLKLELQSDLK-------------------------LPGTTSV 1040

  Fly  1208 NEKNGIKQHDVDLSFETKKLQAVIKGNVVQSEITTSTNMTIKYRFQA---------------NKI 1257
                    ..:.|::|::|::|.:|.:.      .|...|:...|:.               |||
Zfish  1041 --------QTLILTYESEKIEAEVKSHF------NSKTRTLVPLFRTGDTIIIGLLTRQMGQNKI 1091

  Fly  1258 EEINFAGKLVNNGDKSKTEYRGNMKLQTSAYPKLNFASESTWLSLQGHTEGMITYNNAPDYVNPN 1322
            :.::...||        ..:.|.........|      |..:|::    :..:.|:    :..|.
Zfish  1092 KLLDIIAKL--------AAFSGVPATLDITLP------EELFLNI----DAAVKYH----FGQPY 1134

  Fly  1323 YTSLVRLIFARSHSEDSFLDGTQTRASLELKLPRS-KIDYRILVKHKEHI---KNGTEHNVIVGL 1383
            ||..:.|.          |.|..||   :||.|.: ..|..|:....|.:   :.....:|.:.|
Zfish  1135 YTITLPLP----------LGGKSTR---DLKFPTTLSTDLFIVDPDLESMQLPEVSIPESVTLSL 1186

  Fly  1384 KYTPEKEITGLFSVHLPRRNLFAIDAYMNVT--VPEFNSCTASLKV-NEKATKDYIIFINGSWF- 1444
            ......:::|....|     |:.:||.::..  ....:|.:|.||| .....:.:.:.:.||.. 
Zfish  1187 HAFQLADVSGKLRCH-----LYDLDATVSAARDPAAHSSYSAKLKVTGTSPVEQFCLQVEGSALA 1246

  Fly  1445 ---TGHSVAVKANYKDRSSRVQALHHLKMIVESPSFNITSLNIIYRRKQLLIFYDIQAKYDQDPY 1506
               :|.|  :||:             :|.::|...||.|                          
Zfish  1247 EATSGDS--LKAS-------------MKTVIEHKFFNAT-------------------------- 1270

  Fly  1507 GLTIQYASNAHNRNTNAEVRLKVKERDYWINAKLLSEQPKLLQLEIHMDKIRDVHIQVGLLNVDK 1571
             ::::       ....:..:|.||.:.......|::||                           
Zfish  1271 -ISVE-------EEVQSAAKLSVKSKSKLEVTSLVAEQ--------------------------- 1300

  Fly  1572 RKELSLELKWDANRDPSQRLGLLAEYNSPGTKHYDGNLMITYPERTIHFGFNSFTGGPKYFGKVH 1636
               :|:|.......|..|..|             ||||.            .||..     |.::
Zfish  1301 ---MSVEHNAIFEGDAGQISG-------------DGNLE------------GSFKA-----GSIY 1332

  Fly  1637 ASWSINE---VIEFEYEAGILPGHTLHNWVKAE---LRTPFDGWRVNSLDAGIYSLKNLILVNST 1695
            .|.::.:   :|..:.||.|      .:.:|.:   |:..      ||......:.:..:|..:|
Zfish  1333 GSGNLKQSVLLIPSKQEAKI------DSLLKVDSKLLQAQ------NSFSVAFANRELTVLSTTT 1385

  Fly  1696 LFWADD----------QKLQVGYKSDYDVNDQLMSFDVR---FGIN-----STIRDIPTINVKVK 1742
            .|  ||          .:.|:|           :|:..:   ||:.     .|..|...|:||::
Zfish  1386 AF--DDILTNTAKVAINESQIG-----------LSYYTKAQGFGLKIENTAETRADAKAISVKIE 1437

  Fly  1743 HWMDVKKVDTELYLGYSGQNDTFNTYSM--DSSWEIEKNQRYNNYSGLVHLVSPFKGYEKGGLVA 1805
            ...|:.:  ..:|...:|:.| .|..::  |:|.::..::..:|         ....:.|.||.:
Zfish  1438 TSGDLSQ--ERIYSIVTGELD-INGLAIKSDASAKLMGHRAAHN---------AILNFNKDGLTS 1490

  Fly  1806 HFSLSDQRVVSGAASLNFDLREFTLTMNGYVKKFTDNM-LTVNITTPLEKFGTINARFGLN-EKK 1868
            ..:.:.|.::|.....|        |.....||.|.|: ...|     .||  |.|....| |.|
Zfish  1491 SGTTTLQSILSQEKVKN--------TFEVIYKKLTANLQCKTN-----GKF--IGASIDHNTEMK 1540

  Fly  1869 RHAVAEVRAPTAALGVEVLADIKNLLNFDVK-LSVATPIES----FQQAAIFALFNPERVDMRGL 1928
            .:.              :|..|:|:|.|:.: |:|.|....    |.....||....|.|..||.
Zfish  1541 ING--------------LLGRIENILRFNSRILNVETNTRGTTVPFSFNFNFAANGSENVYNRGH 1591

  Fly  1929 WNNVTLGFTGVWHM----QNIT-DFEYSYHVFTPLAGFEENGFIVQLLKRKEFVFQLHGKMSNYK 1988
            :..   .|....|:    ::|| ..|..........||.......:...:.|.:.....:.:...
Zfish  1592 YRE---DFNTKMHLKIDPESITHSHECKISTLVETYGFYGVEVESEFQSKSELLLNPSEQKAKMA 1653

  Fly  1989 LGVKINGEPKSDLVNQL---------GSNKMELEMLYDADFKPLNAETDYKPDADEEYFSYFTNF 2044
            :.||:|....:..:|..         ||.|:...:|..||       .|::..|...:..|..|.
Zfish  1654 VKVKVNKHAINQEINAYNTPAQFGLEGSGKVFTNLLNTAD-------DDHQDFAVSAFLKYDKNN 1711

  Fly  2045 QVDTLVWPTI--VGNVDIQEIIDFYLV------VGHVELPQGKVEFKDRLH-------------- 2087
            |:.::..|.:  :|.|....|:.:..:      :.::.||:....|...::              
Zfish  1712 QMHSIYLPFVDSLGLVPSSVILTYSSIEETLAYLAYLSLPKHVSNFVSNMNFGRRAEQFQRASIA 1776

  Fly  2088 ----YPDYINVH----------------NLLTVTTPFAVAKNIKSIVEYHVDLNFNAFYERVKFI 2132
                ||..:.|:                |...:|....:.:|:..::..|:    ||    :.|:
Zfish  1777 LYQEYPLKLGVYEKQLSDMISQITEALSNFKQLTANGMLIENVDRMLTKHI----NA----LMFL 1833

  Fly  2133 VNDDKDNTQELGFVFNYTALQDNVKPKAH-DVQVTLLT-PYEMLHEIYVHGHIELDDNAYKGNIS 2195
            :.:|            ...|...:||:.| .:|:...| .|::.....:||.|......|..|.|
Zfish  1834 ITED------------VKLLLSLLKPQGHTKLQIPASTKSYQLPCFEKMHGEIRFTSPVYSLNTS 1886

  Fly  2196 A----VTAHTHLSMA---------ASIE----NEDNFLE------TSVGIQLETDAIPHYGCQVY 2237
            |    |:| ||...|         ||:|    |.|..::      |.|.:. ||..|.|    .|
Zfish  1887 AEFKNVSA-THPQFAGVIKSKGISASLEVLNYNIDYTMQISIPEMTPVSVS-ETLKITH----SY 1945

  Fly  2238 FKKDFSAVDKAIDIRFEVTDNGTLNQLHISTDWHTDPSYIVNANGRIKTTMLPLQMASTSVLVIQ 2302
            ...|.||   ::.:...:|.....:.|.:      |.||....|..:.:....:.:||.:|.|.|
Zfish  1946 LTLDQSA---SLTLNASITKGPDFSSLSL------DTSYKNQVNIPLHSLSSEVTLASKAVAVYQ 2001

  Fly  2303 G-----------------------QNPHLNFDLNLLSQNGQSIA-YGARANKKKDVFNIEVWTPM 2343
            .                       :..|   |.:||...|.|.| ...:.:.......:|:    
Zfish  2002 NNAAVILKVLNTGIGKFTLEDFSDEGTH---DSDLLFTMGLSAAKLRLKGHTDSSALQMEM---- 2059

  Fly  2344 KNFRNISMHGTAI-------------RSPRDPGRYDVSGFLYRNMATYEVTGAVRMTNSLPIDVV 2395
                |:.:...|:             :||          |:.:|:..  .:|.|.:.:   :|| 
Zfish  2060 ----NVDVDADAVALSYLKFNVFAETKSP----------FIKKNLLV--ASGNVSIND---MDV- 2104

  Fly  2396 LRVQPKAGGR-----DGVIELNIHEAG-----PKKIRFSFSAIEDGKMCQMSGG-------YSVS 2443
                 |..|.     |||:.:.:....     |::|...|         |..|.       :.::
Zfish  2105 -----KISGNHETEFDGVVSVVLSNTASVIICPREIAVEF---------QNKGNAKTDLYEFLIT 2155

  Fly  2444 KTNGAMDFSVLVESTEPE-----IARINFY---GNLSPNSEGSLVGDLSLETPWKALGIDTVHLH 2500
            ..:...|::|:|.|...|     :|:||.|   .||:.|:..:.:|..:        |:::    
Zfish  2156 SVDLQNDYTVIVNSDLQEVSTIAVAQINHYKYSHNLTANNNNAEIGVYA--------GVNS---- 2208

  Fly  2501 SDVGFLNKGGHIVG---EYKIGQYIGRGSCLWSWILAEDMQLVLENYLERPNAKPRIVHASAKYQ 2562
              .|.||.....|.   :..:.:|:...|.:|.       .....|.....|||       ..||
Zfish  2209 --FGILNNAVQFVPFVFKKAVVEYLKDESGIWH-------DFTTNNQATDLNAK-------LVYQ 2257

  Fly  2563 NPGQTFTQLQAGGRLSV---------------DSKWNLDVNGSAEYKSVDDFKFRVI-TALPLPV 2611
               :|.|.|.....|:|               .|..||:.|... |.  ||:..|:. ||    .
Zfish  2258 ---KTTTVLGDSDGLAVVVPSLGNLVSEVSSTSSILNLNANAGV-YP--DDYLMRISGTA----T 2312

  Fly  2612 GDRHQLSASYQGNVISQQFNNPDFVLEASYESFEAQNKLLSRISYKNATNNLKGLGHVEWGKIQN 2676
            ....||.|...|               |:..:.|:..||.|.:...|:          :.|...|
Zfish  2313 SAFQQLRAKLYG---------------ATIITTESGLKLASTLFLDNS----------QIGGTHN 2352

  Fly  2677 LSV-VEGDFELLHKQGAQREFSAKIITPKFKNEHTFALTGSYDLEKSGHHNVVGSLDYPASRRIT 2740
            .|| ::.::|::.......:.:..|.:  .:.:|..:......|:...:..:..|.|:|.||...
Zfish  2353 SSVTLQDNYEVVLVSDTIAKINLTIFS--IEADHQLSADTKTHLKALSNLKIKYSFDHPDSRGGG 2415

  Fly  2741 DLD-----------VSVSSLSNMHGIFNSTLP-------TFLNVSWLKTDFNFTTN------NGK 2781
            |.:           ::|.|.|.:  ..|||||       |      |.:|.|.:.|      |.|
Zfish  2416 DAENTLKMNAYLSSITVESTSQV--TTNSTLPDGGALKGT------LDSDANISVNVAGLKSNVK 2472

  Fly  2782 SYRYCRCFWPQDTAYFKLNSNYDSDSSNFNHNLNGNVEIEVPLATRHRADIVYGLQKRRNQDAGN 2846
            :               ..|..||..::..:.::|..|.:|                       ||
Zfish  2473 A---------------SANGYYDYRNNKLSFDMNDQVILE-----------------------GN 2499

  Fly  2847 VKVVYNEKQVLD------GKYKRLEQA-KAPIYKETTDISLENEVKPLGIHFVSTRDASDPAGSQ 2904
            ...::   .:||      .||:|.|.| |...:.:||.|.:...:  ..:.|..|:...|     
Zfish  2500 FNRIH---YLLDIDSNYTHKYRREEVAVKHTAHGKTTIIPMSTFM--AAVDFFLTQPDHD----- 2554

  Fly  2905 DVKH--IEIYELRNTQNFNLTGELHSRATLKAQDFKVVAIH--PNRAVVLSTKYEDVSPEV-VRH 2964
            |.:|  .....:..|..:|  |:::||....:....|.:.:  |:|..:|...:...:|.| |.:
Zfish  2555 DFEHRGEGFGYINKTSLYN--GQIYSRWFNSSTAISVESDNDSPDRKFLLECSFNFTAPSVLVEY 2617

  Fly  2965 HSKL 2968
            .|:|
Zfish  2618 ESEL 2621

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ApoltpNP_995670.2 LPD_N 49..633 CDD:214755 147/657 (22%)
Vit_open_b-sht 665..1005 CDD:462702 75/341 (22%)
DUF1081 1027..>1116 CDD:461916 20/93 (22%)
VWD 3741..3908 CDD:214566
C8 3952..4014 CDD:214843
apobb.2XP_002665852.3 Vitellogenin_N 23..535 CDD:460170 142/642 (22%)
Vit_open_b-sht 597..883 CDD:462702 75/341 (22%)
DUF1081 908..1003 CDD:461916 24/124 (19%)
Blue background indicates that the domain is not in the aligned region.

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