Protein Alignment numb and Ldlrap1

DIOPT Version :10

• Sequence 1: NP_523523.2
• Gene: numb / 34263
• FlyBaseID: FBgn0002973
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_663529.2
• Gene: Ldlrap1 / 100017
• MGIID: 2140175
• Length: 308
• Species: Mus musculus
• Alignment Length: 239
• Identity: 61/239 - (25%)
• Similarity: 100/239 - (41%)
• Gaps: 36/239 - (15%)

  Fly    42 MDRLRRSFRDSFRRRKDRVPESSK-----------PHQWQADEEAVRSATCSFSVKYLGCVEVFE 95
            ||.|:     |..|...|.|..:|           |..|....|.:..... ||:||||...|..
Mouse     1 MDALK-----SAGRALIRSPSLAKQSWAGGRHRKLPENWTDTRETLLEGMV-FSLKYLGMTLVER 59

  Fly    96 SRGMQVCEEALK----VLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNH 156
            .:|.::...|:|    ..:.|.::..:..|.||..|:.:.|..|..||.:.:|.::|:|..|:.|
Mouse    60 PKGEELSAAAVKRIVATAKASGKKLQKVTLKVSPRGIILTDSLTSQLIENVSIYRISYCTADKMH 124

  Fly   157 ERGFSYICRDGTTRRWMCHGFLACKDS-GERLSHAVGCAFAVCL-------ERKQRRDK--ECGV 211
            ::.|:||.:........||.||..|.. .:.::..|..||.|..       |.|::|:|  :.|.
Mouse   125 DKVFAYIAQSQQNESLECHAFLCTKRKVAQAVTLTVAQAFKVAFEFWQVSKEEKEKREKANQEGG 189

  Fly   212 TMTFDTKNS-----TFTRTGSFRQQTLTERLAMATVGTNERSVD 250
            .:....::|     |...||:........:..::||..|..:||
Mouse   190 DVPGTRRDSTPSLKTLVATGNLLDLEEVAKAPLSTVSANTNNVD 233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_523523.2	PTB_Numb	67..201	CDD:241298	38/145 (26%)
		NumbF	269..374	CDD:461874
Ldlrap1	NP_663529.2	PTB_LDLRAP-mammal-like	43..165	CDD:269981	34/122 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..201		4/21 (19%)
		Clathrin box. /evidence=ECO:0000250|UniProtKB:Q5SW96	211..215		0/3 (0%)
		AP-2 complex binding. /evidence=ECO:0000250|UniProtKB:Q5SW96	248..275
		[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. /evidence=ECO:0000250|UniProtKB:Q5SW96	256..265
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	288..308