DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-4 and CD180

DIOPT Version :10

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_005573.2 Gene:CD180 / 4064 HGNCID:6726 Length:661 Species:Homo sapiens


Alignment Length:743 Identity:158/743 - (21%)
Similarity:262/743 - (35%) Gaps:238/743 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   357 YKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIP-SLPVPKKGSSALVFQSNLLA 420
            :.:.||.....:::....:.|.:||         |....|:.|| :||   ..:..|.|..|.|.
Human    14 FSAGCKVITSWDQMCIEKEANKTYN---------CENLGLSEIPDTLP---NTTEFLEFSFNFLP 66

  Fly   421 ELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPESLHYLDIRHNKITTL----SPQVVEYLYSVNV 481
            .:.:.:.....||..||     ||...::.:.|....   .|::::||    :|.:.....|:| 
Human    67 TIHNRTFSRLMNLTFLD-----LTRCQINWIHEDTFQ---SHHQLSTLVLTGNPLIFMAETSLN- 122

  Fly   482 FNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFFVQNIDQLYLE 546
                |.|        .|:..|     |::...|.    :|:|.:.:         ::|::.|||.
Human   123 ----GPK--------SLKHLF-----LIQTGISN----LEFIPVHN---------LENLESLYLG 157

  Fly   547 ANEDEIIDAFGPSDKYF---NLKLMEALNHAIWLFS---------------------------GE 581
            :|....|..  |.|  |   |||:::..|:||...|                           |.
Human   158 SNHISSIKF--PKD--FPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGA 218

  Fly   582 FDEIILHHLN---SPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTL----YLDRN 639
            ||..|...||   :|                     |||: |:..|.||......|    .:|..
Human   219 FDSTIFQSLNFGGTP---------------------NLSV-IFNGLQNSTTQSLWLGTFEDIDDE 261

  Fly   640 EIRKL-------TNTESLVVAGH-------------ASIHKLHMSQNLLRELP-----LHLLPE- 678
            :|...       .:.|||.:..|             ..:.:|.::...|:.||     |:||.: 
Human   262 DISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKL 326

  Fly   679 -------------------NITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWE----CN 720
                               ::|:|.:|.| :|.|..|| ..||...|:..::||.|..|    |:
Human   327 VLSVNHFDQLCQISAANFPSLTHLYIRGN-VKKLHLGV-GCLEKLGNLQTLDLSHNDIEASDCCS 389

  Fly   721 CKAK---------------------AF----------LSFLRRH-----EPMEYETVLRRVEITD 749
            .:.|                     ||          |:|.|.|     .|.:....|:.:.:| 
Human   390 LQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLT- 453

  Fly   750 DKCPEDCICCVDTSNSDSLAYV-----VDCSGKELSEIPQLPT---PTYGQ-TTLVFERNSLKKW 805
                   .|.:||||...||.:     ::..|....:.....|   .|.|. ..|:.....|...
Human   454 -------YCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSI 511

  Fly   806 PSSLLPGYSSVTRFYLAHNRLS--DIDQLPD-KLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQ 867
            ..........::...|:||.|:  .||.|.. |..||:::.|:.:.:..|:...|     |.|..
Human   512 DQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPIL-----SQQST 571

  Fly   868 LSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAIQCIDTGRSLIEVEETDI---CPSVLIYYTSL 929
            ::|..||..|.|.:..||.:.||....:..:....|.:. .||..|:.:|:   |....|....|
Human   572 INLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANP-PSLRGVKLSDVKLSCGITAIGIFFL 635

  Fly   930 AVSLLIIALSINVFICFRQPIMIWFYEH 957
            .|.||::|:.:...:.:   ::.|.|:|
Human   636 IVFLLLLAILLFFAVKY---LLRWKYQH 660

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 LRR 210..>470 CDD:443914 25/117 (21%)
leucine-rich repeat 264..287 CDD:275380
leucine-rich repeat 288..308 CDD:275380
leucine-rich repeat 309..334 CDD:275380
leucine-rich repeat 335..386 CDD:275380 5/28 (18%)
PRK15370 <381..>482 CDD:185268 24/105 (23%)
leucine-rich repeat 388..408 CDD:275380 6/20 (30%)
leucine-rich repeat 412..432 CDD:275378 4/19 (21%)
LRR <416..591 CDD:443914 43/208 (21%)
leucine-rich repeat 433..454 CDD:275378 5/20 (25%)
leucine-rich repeat 455..478 CDD:275378 4/26 (15%)
leucine-rich repeat 479..490 CDD:275378 3/10 (30%)
leucine-rich repeat 632..657 CDD:275378 7/48 (15%)
leucine-rich repeat 658..679 CDD:275378 7/45 (16%)
leucine-rich repeat 680..706 CDD:275378 10/25 (40%)
PCC 684..>771 CDD:188093 31/126 (25%)
leucine-rich repeat 707..719 CDD:275378 4/15 (27%)
leucine-rich repeat 771..791 CDD:275380 3/27 (11%)
PRK15370 <793..>877 CDD:185268 20/86 (23%)
leucine-rich repeat 793..815 CDD:275378 2/21 (10%)
leucine-rich repeat 816..835 CDD:275378 7/21 (33%)
leucine-rich repeat 836..859 CDD:275378 5/22 (23%)
TIR 974..1110 CDD:214587
CD180NP_005573.2 LRR <38..310 CDD:443914 70/348 (20%)
leucine-rich repeat 38..57 CDD:275380 7/30 (23%)
LRR 1 54..75 4/20 (20%)
leucine-rich repeat 58..78 CDD:275380 4/19 (21%)
LRR 2 78..99 7/28 (25%)
leucine-rich repeat 79..102 CDD:275380 7/30 (23%)
LRR 3 102..123 5/25 (20%)
leucine-rich repeat 103..126 CDD:275380 7/35 (20%)
LRR 4 126..147 6/29 (21%)
leucine-rich repeat 127..150 CDD:275380 6/40 (15%)
LRR 5 150..171 8/24 (33%)
leucine-rich repeat 151..174 CDD:275380 8/26 (31%)
LRR 6 174..195 7/20 (35%)
leucine-rich repeat 175..195 CDD:275380 6/19 (32%)
leucine-rich repeat 196..234 CDD:275380 7/58 (12%)
LRR 7 201..221 2/19 (11%)
LRR_11 221..249 CDD:408601 11/49 (22%)
leucine-rich repeat 235..275 CDD:275380 9/40 (23%)
LRR <275..553 CDD:443914 60/287 (21%)
LRR 8 275..296 4/20 (20%)
leucine-rich repeat 276..299 CDD:275380 4/22 (18%)
LRR 9 299..320 4/20 (20%)
leucine-rich repeat 300..322 CDD:275380 5/21 (24%)
LRR 10 322..343 2/20 (10%)
leucine-rich repeat 323..371 CDD:275380 11/49 (22%)
LRR 11 346..366 8/21 (38%)
LRR 12 371..391 6/19 (32%)
leucine-rich repeat 372..397 CDD:275380 6/24 (25%)
LRR 13 397..418 2/20 (10%)
leucine-rich repeat 398..421 CDD:275380 2/22 (9%)
LRR 14 421..442 5/20 (25%)
leucine-rich repeat 422..446 CDD:275380 5/23 (22%)
LRR 15 446..466 7/27 (26%)
leucine-rich repeat 447..470 CDD:275380 9/30 (30%)
LRR 16 470..493 2/22 (9%)
leucine-rich repeat 471..497 CDD:275380 3/25 (12%)
LRR 17 497..518 2/20 (10%)
leucine-rich repeat 498..521 CDD:275380 2/22 (9%)
LRR 18 521..544 7/22 (32%)
leucine-rich repeat 522..543 CDD:275380 7/20 (35%)
LRR 19 546..564 4/17 (24%)
PCC 549..>626 CDD:188093 19/82 (23%)
Blue background indicates that the domain is not in the aligned region.

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