DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-4 and Tlr2

DIOPT Version :10

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:XP_008759324.3 Gene:Tlr2 / 310553 RGDID:735138 Length:831 Species:Rattus norvegicus


Alignment Length:900 Identity:194/900 - (21%)
Similarity:327/900 - (36%) Gaps:318/900 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   374 LKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDV 438
            |.|:.:...|.|       .::.|:|||      |.:|                    |.|.||:
  Rat    75 LSCDAAGVCDGS-------SRSFTSIPS------GLTA--------------------NTKKLDL 106

  Fly   439 SYNQLT-----------SLSVSQLPE---------------SLHYLDIRHNKITTLSPQVVEYLY 477
            |:|::|           :|.|..|..               ||.:||:.:|.:::||......|.
  Rat   107 SFNKITYIGHGDLRACVNLRVLTLESSGINTIEGDAFYSLGSLEHLDLSNNHLSSLSSSWFRPLS 171

  Fly   478 SVNVFNQYGNKW------SIYCDEYHLQ-------EFFWYKAKLLRI------------------ 511
            |:...|..||.:      |::.:..:||       :.|   :::.||                  
  Rat   172 SLKYLNLMGNPYRTLGETSLFSNLTNLQNLRVGNVDTF---SEIRRIDFAGLTSLNELEIQVLSL 233

  Fly   512 ---KTSKFQTIMEYIELS---SKGSFVENFFVQNIDQL-YLEANE-------------DEIID-- 554
               ::...|:|.:...|:   |:.:|:...|...:..: |||..:             |||..  
  Rat   234 GNYESRSLQSIRDIYHLTLHLSESAFLLGIFADILSSVRYLELRDTNLARFQFSELSVDEINSPM 298

  Fly   555 ---AF---GPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINC 613
               ||   ..:||.|| :|::.|.:.:.|...|||...|:.:.:..|.......|....| .:..
  Rat   299 KKLAFRNADLTDKSFN-ELLKLLRYILELMEVEFDHCTLNGVGNFNPSESDVVRELGKVE-TVTI 361

  Fly   614 RNLSL----------DIYPRL--------PNS----IPYKTTLYLDRNEIRKLTNTESLVV---- 652
            |:|.:          .:|..|        .||    :|...:.:|...|...|  :|:|:|    
  Rat   362 RSLHIPQFYLFYDLSTVYSLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDL--SENLMVEEYL 424

  Fly   653 ------AGHASIHKLHMSQNLLREL----PLHLLPENITYLDVRNNLLKYLDDGVIAFLEYRENI 707
                  .|..|:..|.:|||.||.:    .:.|..:|:|.||:..|                   
  Rat   425 KNSACEGGWPSLQSLVLSQNHLRSIRKTAEILLTLKNLTALDISKN------------------- 470

  Fly   708 TKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNS--DSLAY 770
                 |..|...:|:....:.||...     .|.::.|:    .|....:..:|.||:  ||.:.
  Rat   471 -----SFQPMPDSCQWPGKMRFLNLS-----STGIQAVK----TCIPQTLEVLDVSNNNLDSFSL 521

  Fly   771 VVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWP-SSLLPGYSSVTRFYLAHNRLSDI--DQL 832
            .          :|:|       ..|...||.||..| :||.|....:.   :..|.:|..  |||
  Rat   522 F----------LPRL-------QELYISRNKLKTLPEASLFPVLQVMK---IRENAISTFSKDQL 566

  Fly   833 PD--KLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNI 895
            ..  |||.|:..:|:|                             .|.||   .|.|:.|:...:
  Rat   567 GSFPKLETLEAGDNHF-----------------------------ICSCE---LLSFILERPALV 599

  Fly   896 ANASAIQCIDTGRSLIEVEETDIC---------------PSVLIYYTSLAVS-----LLIIALSI 940
                        ..|::..::.:|               ||||..:.:..||     ||::.|.:
  Rat   600 ------------HVLVDWPDSYLCDSPPRLHGQRLQDARPSVLECHQAALVSGVCCALLLLILLL 652

  Fly   941 NVFICFR-----QPIMIWFYEHEICLSLAARRELDE----DKKYDAFLSFTHKDEDLIEE-FVDR 995
            .. :|:.     ...|:|.:       |.|:|:..:    |..||||:|::.:|...:|. .|.:
  Rat   653 GA-LCYHFHGLWYLRMMWAW-------LRAKRKPKKAPCRDLCYDAFVSYSEQDSYWVENLMVQQ 709

  Fly   996 LENGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLE-----FRLALH 1055
            |||....|:||.:.||::.|:.|.|.|..|::.|.:.:.::::||::|.|.:.|     |||   
  Rat   710 LENSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDFSHFRL--- 771

  Fly  1056 ATSRDRCKRLIVVLYP-DVEHFDDLDSELRAYMVLNTYL-----DRNNPNFWNKL 1104
             ...:....::|:|.| :.:.......:||..|...|||     :.....||..|
  Rat   772 -FDENNDAAILVLLEPIEKKAIPQRFCKLRKIMNTKTYLEWPLDEGQREVFWANL 825

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 LRR 210..>470 CDD:443914 26/121 (21%)
leucine-rich repeat 264..287 CDD:275380
leucine-rich repeat 288..308 CDD:275380
leucine-rich repeat 309..334 CDD:275380
leucine-rich repeat 335..386 CDD:275380 3/11 (27%)
PRK15370 <381..>482 CDD:185268 27/126 (21%)
leucine-rich repeat 388..408 CDD:275380 4/19 (21%)
leucine-rich repeat 412..432 CDD:275378 0/19 (0%)
LRR <416..591 CDD:443914 53/259 (20%)
leucine-rich repeat 433..454 CDD:275378 9/46 (20%)
leucine-rich repeat 455..478 CDD:275378 7/22 (32%)
leucine-rich repeat 479..490 CDD:275378 3/16 (19%)
leucine-rich repeat 632..657 CDD:275378 7/34 (21%)
leucine-rich repeat 658..679 CDD:275378 7/24 (29%)
leucine-rich repeat 680..706 CDD:275378 4/25 (16%)
PCC 684..>771 CDD:188093 15/88 (17%)
leucine-rich repeat 707..719 CDD:275378 2/11 (18%)
leucine-rich repeat 771..791 CDD:275380 2/19 (11%)
PRK15370 <793..>877 CDD:185268 20/88 (23%)
leucine-rich repeat 793..815 CDD:275378 9/22 (41%)
leucine-rich repeat 816..835 CDD:275378 5/22 (23%)
leucine-rich repeat 836..859 CDD:275378 5/22 (23%)
TIR 974..1110 CDD:214587 41/142 (29%)
Tlr2XP_008759324.3 LRR <86..337 CDD:443914 59/287 (21%)
leucine-rich repeat 101..124 CDD:275378 6/22 (27%)
leucine-rich repeat 125..148 CDD:275378 3/22 (14%)
leucine-rich repeat 149..172 CDD:275378 7/22 (32%)
leucine-rich repeat 173..197 CDD:275378 4/23 (17%)
leucine-rich repeat 229..249 CDD:275380 2/19 (11%)
leucine-rich repeat 250..270 CDD:275380 4/19 (21%)
LRR <382..>598 CDD:443914 65/302 (22%)
leucine-rich repeat 409..435 CDD:275380 6/27 (22%)
leucine-rich repeat 436..461 CDD:275380 7/24 (29%)
leucine-rich repeat 462..484 CDD:275380 7/45 (16%)
leucine-rich repeat 485..505 CDD:275380 5/28 (18%)
leucine-rich repeat 506..525 CDD:275380 5/28 (18%)
leucine-rich repeat 526..547 CDD:275380 9/27 (33%)
leucine-rich repeat 548..571 CDD:275380 5/25 (20%)
LRRCT 580..633 CDD:214507 14/96 (15%)
TIR 687..831 CDD:214587 41/142 (29%)
Blue background indicates that the domain is not in the aligned region.

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