Protein Alignment Toll-4 and Tlr10

DIOPT Version :10

• Sequence 1: NP_523519.2
• Gene: Toll-4 / 34235
• FlyBaseID: FBgn0032095
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_001139507.2
• Gene: Tlr10 / 305355
• RGDID: 1311569
• Length: 811
• Species: Rattus norvegicus
• Alignment Length: 1014
• Identity: 208/1014 - (20%)
• Similarity: 356/1014 - (35%)
• Gaps: 340/1014 - (33%)

  Fly   218 TVNSVI--TNNYIRKTMNNTEKIKIYYHNTFEK---------TTLTMEKNIFHGKNKMSALIFNG 271
            |:.::|  |..:..:..:..|.|..|.:....|         |.|.:..|:.:.........|:.
  Rat     9 TLYNIIMSTEAWAPRPTDERELISNYSNMALRKVPPDVTPATTILDLSYNLLYQFQSSDCHSFSK 73

  Fly   272 LKIKGLTNNTFENLTSLNTLIFDNVFLKDLSFLRSS--TLQSSLTYCIMKVDNMVDLK----SFE 330
            |:...|.:|:.:   .|:|.|||  ..|:||:|..|  .|| |:|:     .::|||:    ||.
  Rat    74 LRFLILCHNSIQ---QLDTKIFD--LNKELSYLDLSYNRLQ-SITW-----SSLVDLRHLDLSFN 127

  Fly   331 KFTNL----EI---------------IEVSQYKGFKNF---TAFICEPYKSHCKFTLGINEVACP 373
            .|..|    ||               |:.|..:...|.   |.||            |:|.:
  Rat   128 DFDTLPACEEIGNMRHLETLGLSGAKIQRSDLQKIANLQFSTVFI------------GLNTL--- 177

  Fly   374 LKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKG-----------SSALVFQSNLLAELPDNSL 427
                 |:..:.|...::      ||:..:.:|...           :|.:|..||:
  Rat   178 -----SHYEEGSLPVLN------TTVLHIVLPMAANFWVLLCDGMKTSKVVEMSNI--------- 222

  Fly   428 EGYHNLKSLDVSYNQLTSLSVSQLPESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIY 492
                ..||..|||            |:...|.:.:.|.:||            :|::....|.
  Rat   223 ----GGKSQFVSY------------ETPRTLSVENTKASTL------------IFHKVDLLWD-- 257

  Fly   493 CDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFFVQNIDQLYLEANEDEIIDAFG 557
             |..|:.:|.|        :||                 ||.|.:|::....: |:.|.  .:|.
  Rat   258 -DLLHVFQFVW--------RTS-----------------VECFQIQDLTFGGM-ASRDH--SSFD 293

  Fly   558 PSDKYFNLKLMEALN--------HAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEF--LIN 612
            .|:......::|:::        :.|:||   |.::.|.:|...........|..|...|  |..
  Rat   294 YSNTVMKAVILESIHFRIFFIPQNKIYLF---FTQMDLENLTISDAQMPHLLFPSHPQSFQHLNF 355

  Fly   613 CRNLSLDIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLV--VAGHASIHKLHMSQNLLRELPLHL 675
            ..|:..|...:.|..:||..||.|..|::..|    |||  .|.|.|:..|.:|||||:.
  Rat   356 ANNILTDDLFKNPIQMPYLKTLVLRGNQLETL----SLVSLFANHTSLLHLDLSQNLLQH----- 411

  Fly   676 LPENITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYET 740
                                                  ||
  Rat   412 --------------------------------------GN------------------------- 413

  Fly   741 VLRRVEITDDKCP-EDCICCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKK 804
                    .:||. .|.:..::.|::.....|..|..|.:.             ||....|.::.
  Rat   414 --------GEKCMWPDTLILLNLSSNKFDGSVFRCLPKSIQ-------------TLDLNNNKIRA 457

  Fly   805 WPSSLLPGY-SSVTRFYLAHNRLSDIDQLPDKLEYLDISNNNFS-------ALDDRVRGFLQ--- 858
            .|..::  | .|:....:|.|.|:|   ||....:..:|:.|..       :||     |.|
  Rat   458 VPKEII--YLKSLRELSIAFNFLTD---LPGCDHFKQLSSLNIEMNLILSPSLD-----FFQSCQ 512

  Fly   859 --KRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIAN------ASAIQCIDTGRSLIEVEE 915
              |.:|:.:       ||:.|.||.:|| :::::.:|.:.:      |........|..|.:|..
  Rat   513 EVKTLNAGR-------NPFRCICEFRDF-IWLEKHSKGLMSGWPDSYACEYPLSLKGTPLKDVYL 569

  Fly   916 TDI-CPSVLIYYTSLAVSLLIIALSINVFICFRQPIMIWFY---------EHEICLSLAARRELD 970
            .:: |.:.|:..|   :.|:|:.|.:.|..|..:..|:|:.         :|.|      |:.:.
  Rat   570 PELACNTTLLIVT---IVLVILVLGLVVAFCILKFDMLWYLRVLAQCIRTQHRI------RKTVR 625

  Fly   971 EDKK----YDAFLSFTHKDEDLIE-EFVDRLENGRHKFRLCFYLR----DWLVGESIPDCINQSV 1026
            |::|    :.||:|:...|...:: |.:..||.......||...|    |..:.|:|..|..:|.
  Rat   626 EERKRSIQFHAFISYAAHDSVWVKNELIPNLETEDGSVLLCLPERNFDPDRSIAENIISCTEKSY 690

  Fly  1027 KGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHF--DDLDSELRAYMVL 1089
            |.    |.:::.||:::.|...|..||.|...||....:|.:|...:..:  .....:|:|.:..
  Rat   691 KS----IFVLSPNFVQNGWCHNELYLAHHNPFRDNYDYIIPILLEPIPSYCVPTKFPKLKALLEK 751

  Fly  1090 NTYLD-----RNNPNFWNKLMYSMPHASHLKRSRSDAET 1123
            ..||:     |.:..||..|..::.......|.|.:.:|
  Rat   752 KVYLEWPKDRRKHGLFWANLRAAINVNLSDTRGRCELQT 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	LRR	210..>470	CDD:443914	64/301 (21%)
		leucine-rich repeat	264..287	CDD:275380	4/22 (18%)
		leucine-rich repeat	288..308	CDD:275380	10/21 (48%)
		leucine-rich repeat	309..334	CDD:275380	10/28 (36%)
		leucine-rich repeat	335..386	CDD:275380	12/72 (17%)
		PRK15370	<381..>482	CDD:185268	18/111 (16%)
		leucine-rich repeat	388..408	CDD:275380	3/19 (16%)
		leucine-rich repeat	412..432	CDD:275378	3/19 (16%)
		LRR	<416..591	CDD:443914	34/182 (19%)
		leucine-rich repeat	433..454	CDD:275378	5/20 (25%)
		leucine-rich repeat	455..478	CDD:275378	4/22 (18%)
		leucine-rich repeat	479..490	CDD:275378	1/10 (10%)
		leucine-rich repeat	632..657	CDD:275378	10/26 (38%)
		leucine-rich repeat	658..679	CDD:275378	6/20 (30%)
		leucine-rich repeat	680..706	CDD:275378	0/25 (0%)
		PCC	684..>771	CDD:188093	6/87 (7%)
		leucine-rich repeat	707..719	CDD:275378	2/11 (18%)
		leucine-rich repeat	771..791	CDD:275380	3/19 (16%)
		PRK15370	<793..>877	CDD:185268	22/96 (23%)
		leucine-rich repeat	793..815	CDD:275378	5/22 (23%)
		leucine-rich repeat	816..835	CDD:275378	6/18 (33%)
		leucine-rich repeat	836..859	CDD:275378	6/34 (18%)
		TIR	974..1110	CDD:214587	37/151 (25%)
Tlr10	NP_001139507.2	None