DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-4 and Tlr6

DIOPT Version :10

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_997487.2 Gene:Tlr6 / 305353 RGDID:1303030 Length:806 Species:Rattus norvegicus


Alignment Length:892 Identity:188/892 - (21%)
Similarity:330/892 - (36%) Gaps:270/892 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   376 CNCSYNR------------------------DKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQS 416
            ||.|.:|                        |:.:..:|...||||.:|....|  .:.:|....
  Rat    10 CNMSQDREPIVESFHFVCTLALIVGSMTQFSDEFESVVDYSNKNLTHVPKDLSP--STKSLSLSQ 72

  Fly   417 NLLAELPDNSLEGYHNLKSLDVSYNQLTSL--SVSQLPESLHYLDIRHNKITTLS--PQV-VEYL 476
            |.:::|..:.:.....|:.|.:|:|::..|  .|..|...|.|||:.||::..:|  |.| :::|
  Rat    73 NSISDLQMSDISFLSELRVLRLSHNRIRRLDFGVFLLNRDLEYLDVSHNQLQNISCCPMVNLKHL 137

  Fly   477 -YSVN------VFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQ--------------TIM 520
             .|.|      |:.::||               ..|...|.:..:||:              .::
  Rat   138 DLSFNDFEVLPVYKEFGN---------------LMKLSFLGLSAAKFRQLDLLPISHLHLSCVLL 187

  Fly   521 EYIELSSKGSFVENFFVQNIDQLYLEANEDEI--------IDAFGPSDKYFNLKLMEALNHAIWL 577
            :.:....|....|:..|.|.:.|:|..:.:.:        ::|.| ..:..|:||.:....::.:
  Rat   188 DLVNYQIKDGETESLQVPNTNVLHLVFHPNSLFSVQVNISVNALG-CLQLSNIKLNDKNCQSLII 251

  Fly   578 FSGEFD------EIILHHL--NSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTL 634
            |..|..      .:.|.|:  |..|..|. ..|.|......:|..||:      :..||..:|.:
  Rat   252 FLSELTRGPTLLNLTLQHIETNWKCFVRL-LQFLWPRPVEYLNIYNLT------ITESISRETFI 309

  Fly   635 Y----LDRNEIRKLTNTESLVV--AGHASIHKLHMSQNLLRELP-LHLL-PENITYLDVRNNLLK 691
            |    |...:|..:||...|.|  |.::...::::....|.:.| :|:: ||             
  Rat   310 YVETVLKSLKIEHVTNQVFLFVKDALYSVFAEMNIRMLTLSDTPFIHMVCPE------------- 361

  Fly   692 YLDDGVIAFLEYRENI-TKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPED 755
              .....|||.:.:|: |.....|      |      |.|:|.|.:    :|:|           
  Rat   362 --FPSTFAFLNFTQNVFTDSIFQG------C------STLKRLETL----ILQR----------- 397

  Fly   756 CICCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFY 820
                    |.....:.|....|.:|.:..|........:.|::|..  .|.       .|:....
  Rat   398 --------NGLKNLFKVALMTKTMSSLETLDVSLNSLNSHVYDRTC--AWA-------ESIRVLN 445

  Fly   821 LAHNRLSD--IDQLPDKLEYLDISNNN--------------------------------FSALDD 851
            |:.|.|||  ...||.|::.||:.||.                                ||:|..
  Rat   446 LSSNVLSDSVFRCLPPKVKVLDLHNNRIVSIPKDVTHLQALQELNVASNFLTDLPGCGAFSSLSV 510

  Fly   852 RV----------RGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAIQCIDT 906
            .|          ..|.|...|...:...  .||:.|.||.::|:       |||..||       
  Rat   511 LVIDHNSVSHPSSDFFQSCQNIRSITAG--NNPFRCTCELREFV-------KNIGQAS------- 559

  Fly   907 GRSLIE-------------VEETDI---------CPSVLIYYTSLAVSLLIIALSINVFICFRQP 949
             |.::|             ::.|.:         |.::|:..|..|..||:.|:..::.:.|..|
  Rat   560 -REVVEGWPDSYRCDYPDSIKGTPLQDFHMSPLSCDTILLTVTIGATLLLLAAIGASLCLYFDLP 623

  Fly   950 ---IMIWFY---EHEICLSLAAR----RELDEDKKYDAFLSFTHKDEDLIE-EFVDRLENGRHKF 1003
               .|:|.:   .|.      ||    .||..:.::.||:|::..|...:: |.:..||  :...
  Rat   624 WYLRMLWQWTQTRHR------ARNIPLEELQRNLQFHAFVSYSEHDSAWVKNELLPNLE--KDDI 680

  Fly  1004 RLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVV 1068
            |:|.:.|:::.|:||.:.|...::.|.:.|.:::.:|::|.|...|...|.|....:....||::
  Rat   681 RVCLHERNFVPGKSIVENIIHFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILI 745

  Fly  1069 LYPDVEHFDDLDS---ELRAYMVLNTYLD-----RNNPNFWNKLMYS 1107
            |...::. :::.|   :|||.|...|||:     .....||..|..|
  Rat   746 LLEPIQQ-NNIPSRYHKLRALMAQRTYLEWPIEKGKRGLFWANLRAS 791

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 LRR 210..>470 CDD:443914 29/121 (24%)
leucine-rich repeat 264..287 CDD:275380
leucine-rich repeat 288..308 CDD:275380
leucine-rich repeat 309..334 CDD:275380
leucine-rich repeat 335..386 CDD:275380 5/33 (15%)
PRK15370 <381..>482 CDD:185268 31/136 (23%)
leucine-rich repeat 388..408 CDD:275380 7/19 (37%)
leucine-rich repeat 412..432 CDD:275378 3/19 (16%)
LRR <416..591 CDD:443914 43/216 (20%)
leucine-rich repeat 433..454 CDD:275378 7/22 (32%)
leucine-rich repeat 455..478 CDD:275378 10/26 (38%)
leucine-rich repeat 479..490 CDD:275378 4/16 (25%)
leucine-rich repeat 632..657 CDD:275378 9/30 (30%)
leucine-rich repeat 658..679 CDD:275378 4/22 (18%)
leucine-rich repeat 680..706 CDD:275378 3/25 (12%)
PCC 684..>771 CDD:188093 14/87 (16%)
leucine-rich repeat 707..719 CDD:275378 2/12 (17%)
leucine-rich repeat 771..791 CDD:275380 4/19 (21%)
PRK15370 <793..>877 CDD:185268 25/127 (20%)
leucine-rich repeat 793..815 CDD:275378 3/21 (14%)
leucine-rich repeat 816..835 CDD:275378 7/20 (35%)
leucine-rich repeat 836..859 CDD:275378 9/64 (14%)
TIR 974..1110 CDD:214587 37/143 (26%)
Tlr6NP_997487.2 None
Blue background indicates that the domain is not in the aligned region.

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