DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-4 and Tlr4

DIOPT Version :10

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_067272.1 Gene:Tlr4 / 21898 MGIID:96824 Length:835 Species:Mus musculus


Alignment Length:970 Identity:207/970 - (21%)
Similarity:371/970 - (38%) Gaps:304/970 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   224 TNNYIRKTMNNTEKIKIYYHNTFEKTTL---------TMEKNIFHGKNKMSALIFNGLKIKGLTN 279
            |.| |..:.|..:.:|.|..:.|.:...         |:|...:||.:.:|.||..|..|:..:.
Mouse    55 TKN-IDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSP 118

  Fly   280 NTFENLTSLNTLIFDNVFLKDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEKFTNLEIIEVSQYK 344
            .:|..||||                                :|:|.:::  |..:||...:.|..
Mouse   119 GSFSGLTSL--------------------------------ENLVAVET--KLASLESFPIGQLI 149

  Fly   345 GFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGS 409
            ..|                           |.|.::|                .|.|..:|    
Mouse   150 TLK---------------------------KLNVAHN----------------FIHSCKLP---- 167

  Fly   410 SALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPESLHYLDIRHNKITTLSPQVVE 474
               .:.|||.            ||..:|:|||.:.:::|:.|.      .:|.|....||..:  
Mouse   168 ---AYFSNLT------------NLVHVDLSYNYIQTITVNDLQ------FLRENPQVNLSLDM-- 209

  Fly   475 YLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSF----VENF 535
               |:|..                 :|         |:...||.|..: ||:.:|:|    :...
Mouse   210 ---SLNPI-----------------DF---------IQDQAFQGIKLH-ELTLRGNFNSSNIMKT 244

  Fly   536 FVQNIDQLYL------EANEDEIIDAFGPSDKYFNLKLMEAL-----NHAIWLFSGEF-DEIILH 588
            .:||:..|::      |..::..::.|.||       :||.|     :.....::.:| |:|:..
Mouse   245 CLQNLAGLHVHRLILGEFKDERNLEIFEPS-------IMEGLCDVTIDEFRLTYTNDFSDDIVKF 302

  Fly   589 HLNSPCPYRCSCC----------------FEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLD 637
            |    |....|..                |:|.:.. :|.|:   |..:|.|  .:|:..:|.|.
Mouse   303 H----CLANVSAMSLAGVSIKYLEDVPKHFKWQSLS-IIRCQ---LKQFPTL--DLPFLKSLTLT 357

  Fly   638 RNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHLLPENITYLDVRNNLLKYLDDGVIAFLE 702
            .|:             |..|..|:             .|| :::|||:..|.|.:  .|..::.:
Mouse   358 MNK-------------GSISFKKV-------------ALP-SLSYLDLSRNALSF--SGCCSYSD 393

  Fly   703 YREN-ITKIELSGNPWECNCKAKAFLSFLR-RHEPMEYETVLRRVEITDDKCPEDCICCVDTSNS 765
            ...| :..::||.|  .....:..|:.... :|...::.|:.|..|.:.....|. :..:|.|.:
Mouse   394 LGTNSLRHLDLSFN--GAIIMSANFMGLEELQHLDFQHSTLKRVTEFSAFLSLEK-LLYLDISYT 455

  Fly   766 DSLAYVVDCSGKELSEIPQLPTPTYGQTTL--------VFERNSLKKWPSSLLPGYSSVTRFYLA 822
            ::   .:|..|..|           |.|:|        .|:.|:|    |::....:::|...|:
Mouse   456 NT---KIDFDGIFL-----------GLTSLNTLKMAGNSFKDNTL----SNVFANTTNLTFLDLS 502

  Fly   823 HNRLSDI-----DQLPDKLEYLDISNNNFSALD-----------------DRV---RGFLQKRMN 862
            ..:|..|     |.| .:|:.|::|:||...||                 :|:   :|.|| ...
Mouse   503 KCQLEQISWGVFDTL-HRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKGILQ-HFP 565

  Fly   863 SSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAIQC---IDTGRSLIEVEETDICPSVLI 924
            .|....:|..|...|.||.:.||.:||||.:.:.|...:.|   ::...||:.......|   .:
Mouse   566 KSLAFFNLTNNSVACICEHQKFLQWVKEQKQFLVNVEQMTCATPVEMNTSLVLDFNNSTC---YM 627

  Fly   925 YYTSLAVSLL-IIALSINVFICFRQPIMIWFYEHEICLSLAARRELDEDKKYDAFLSFTHKDEDL 988
            |.|.::||:: :|.:|...|:.:.      ||.|.|.:: ..::....:..||||:.::.::||.
Mouse   628 YKTIISVSVVSVIVVSTVAFLIYH------FYFHLILIA-GCKKYSRGESIYDAFVIYSSQNEDW 685

  Fly   989 I-EEFVDRLENGRHKFRLCFYLRDWLVGESI-PDCINQSVKGSRRIIILMTKNFLKSTWGRLEFR 1051
            : .|.|..||.|..:|.||.:.||::.|.:| .:.|.:....||::|::::::|::|.|...|:.
Mouse   686 VRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYE 750

  Fly  1052 LALHATSRDRCKRLIVVLYPDVEHFDDLDSELRAYMVL--NTYLD-RNNP----NFWNKL 1104
            :|...........:|.::...||. ..|..::..|.:|  ||||: .:||    .||.:|
Mouse   751 IAQTWQFLSSRSGIIFIVLEKVEK-SLLRQQVELYRLLSRNTYLEWEDNPLGRHIFWRRL 809

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 LRR 210..>470 CDD:443914 48/254 (19%)
leucine-rich repeat 264..287 CDD:275380 7/22 (32%)
leucine-rich repeat 288..308 CDD:275380 1/19 (5%)
leucine-rich repeat 309..334 CDD:275380 3/24 (13%)
leucine-rich repeat 335..386 CDD:275380 7/50 (14%)
PRK15370 <381..>482 CDD:185268 21/100 (21%)
leucine-rich repeat 388..408 CDD:275380 3/19 (16%)
leucine-rich repeat 412..432 CDD:275378 3/19 (16%)
LRR <416..591 CDD:443914 40/190 (21%)
leucine-rich repeat 433..454 CDD:275378 7/20 (35%)
leucine-rich repeat 455..478 CDD:275378 4/22 (18%)
leucine-rich repeat 479..490 CDD:275378 1/10 (10%)
leucine-rich repeat 632..657 CDD:275378 4/24 (17%)
leucine-rich repeat 658..679 CDD:275378 3/20 (15%)
leucine-rich repeat 680..706 CDD:275378 6/25 (24%)
PCC 684..>771 CDD:188093 16/88 (18%)
leucine-rich repeat 707..719 CDD:275378 3/11 (27%)
leucine-rich repeat 771..791 CDD:275380 3/19 (16%)
PRK15370 <793..>877 CDD:185268 26/116 (22%)
leucine-rich repeat 793..815 CDD:275378 6/29 (21%)
leucine-rich repeat 816..835 CDD:275378 6/23 (26%)
leucine-rich repeat 836..859 CDD:275378 10/42 (24%)
TIR 974..1110 CDD:214587 42/140 (30%)
Tlr4NP_067272.1 LRR <53..298 CDD:443914 71/384 (18%)
LRR 1. /evidence=ECO:0000255 54..75 6/20 (30%)
leucine-rich repeat 58..78 CDD:275380 5/19 (26%)
LRR 2. /evidence=ECO:0000255 78..99 2/20 (10%)
leucine-rich repeat 79..102 CDD:275380 4/22 (18%)
LRR 3. /evidence=ECO:0000255 102..123 6/20 (30%)
leucine-rich repeat 103..126 CDD:275380 7/22 (32%)
LRR 4. /evidence=ECO:0000255 126..147 7/54 (13%)
leucine-rich repeat 127..150 CDD:275380 7/56 (13%)
LRR 5. /evidence=ECO:0000255 150..171 7/70 (10%)
leucine-rich repeat 151..175 CDD:275380 10/85 (12%)
LRR 6. /evidence=ECO:0000255 175..198 8/28 (29%)
leucine-rich repeat 176..204 CDD:275380 9/33 (27%)
LRR 7. /evidence=ECO:0000255 204..224 7/50 (14%)
leucine-rich repeat 205..226 CDD:275380 8/51 (16%)
LRR 8. /evidence=ECO:0000255 226..247 4/21 (19%)
LRR 9. /evidence=ECO:0000255 248..269 3/20 (15%)
LRR 10. /evidence=ECO:0000255 329..349 6/25 (24%)
leucine-rich repeat 331..350 CDD:275380 5/24 (21%)
LRR <347..>580 CDD:443914 57/284 (20%)
LRR 11. /evidence=ECO:0000255 350..370 6/45 (13%)
leucine-rich repeat 351..372 CDD:275380 8/47 (17%)
LRR 12. /evidence=ECO:0000255 372..392 6/21 (29%)
leucine-rich repeat 373..398 CDD:275380 6/26 (23%)
LRR 13. /evidence=ECO:0000255 398..420 4/23 (17%)
leucine-rich repeat 399..421 CDD:275380 4/23 (17%)
LRR 14. /evidence=ECO:0000255 421..442 4/20 (20%)
leucine-rich repeat 422..446 CDD:275380 4/23 (17%)
LRR 15. /evidence=ECO:0000255 446..467 5/35 (14%)
leucine-rich repeat 447..470 CDD:275380 6/36 (17%)
LRR 16. /evidence=ECO:0000255 470..490 5/23 (22%)
leucine-rich repeat 471..495 CDD:275380 5/27 (19%)
LRR 17. /evidence=ECO:0000255 495..516 4/20 (20%)
leucine-rich repeat 496..519 CDD:275380 6/23 (26%)
LRR 18. /evidence=ECO:0000255 519..540 7/20 (35%)
leucine-rich repeat 520..543 CDD:275380 7/22 (32%)
LRR 19. /evidence=ECO:0000255 543..564 4/21 (19%)
Interaction with SCIMP. /evidence=ECO:0000269|PubMed:28098138 670..835 42/141 (30%)
TIR 672..813 CDD:214587 42/139 (30%)

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