DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-4 and Tlr1

DIOPT Version :10

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_109607.1 Gene:Tlr1 / 21897 MGIID:1341295 Length:795 Species:Mus musculus


Alignment Length:903 Identity:181/903 - (20%)
Similarity:321/903 - (35%) Gaps:287/903 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   360 HCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIP-SLPVPKKGSSALVFQSNLLAELP 423
            :|...||:..:...|...|       :|.|.....|||.:| .||:.   ::.|....|.::||.
Mouse    10 YCIIVLGLTLMKIQLSEEC-------ELIIKRPNANLTRVPKDLPLQ---TTTLDLSQNNISELQ 64

  Fly   424 DNSLEGYHNLKSLDVSYNQLTSLSVS--QLPESLHYLDIRHN--KITTLSPQV-VEYL-YSVNVF 482
            .:.:.....|:.|.:|||:|..|::|  :....|.|||:.||  |:....|.| :::| .|.|.|
Mouse    65 TSDILSLSKLRVLIMSYNRLQYLNISVFKFNTELEYLDLSHNELKVILCHPTVSLKHLDLSFNAF 129

  Fly   483 N------QYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFFVQNID 541
            :      ::||                             .:.::::.||  ||.|::..||.|.
Mouse   130 DALPICKEFGN-----------------------------MSQLQFLGLS--GSRVQSSSVQLIA 163

  Fly   542 QLYLEANEDEII----DAFGPSDKYFNLKLM--EALNHAIWLFSGEFDEII---------LHHLN 591
            .|    |..:::    ||:|..:...:|:.:  |.| |.::....||..::         |...|
Mouse   164 HL----NISKVLLVLGDAYGEKEDPESLRHVSTETL-HIVFPSKREFRFLLDVSVSTTIGLELSN 223

  Fly   592 SPCPYRCSCC------------------------------------FEWHTGEFLINCRNLSLDI 620
            ..|......|                                    ..|||.....:..|:    
Mouse   224 IKCVLEDQGCSYFLRALSKLGKNLKLSNLTLNNVETTWNSFINILQIVWHTPVKYFSISNV---- 284

  Fly   621 YPRLPNSIPYKTTLYLDRNEIRKLT-----------------------NTESLVVAGHASIHKLH 662
              :|...:.::...|.| ..::.|:                       |.::..::|...:|.|.
Mouse   285 --KLQGQLAFRMFNYSD-TSLKALSIHQVVTDVFSFPQSYIYSIFANMNIQNFTMSGTHMVHMLC 346

  Fly   663 MSQ-----------------------NLLRELPLHLLP------ENITY----------LDVRNN 688
            .||                       ||:|...|.|..      |||..          ||:..|
Mouse   347 PSQVSPFLHVDFTDNLLTDMVFKDCRNLVRLKTLSLQKNQLKNLENIILTSAKMTSLQKLDISQN 411

  Fly   689 LLKYLDDGVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCP 753
            .|:|.|.|:..  .:.:::..:.||.|                    |...:|.|          
Mouse   412 SLRYSDGGIPC--AWTQSLLVLNLSSN--------------------MLTGSVFR---------- 444

  Fly   754 EDCICCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPG---YSS 815
                 |:...     ..|:|.....:..||:..|.......|....|||..     |||   :||
Mouse   445 -----CLPPK-----VKVLDLHNNRIMSIPKDVTHLQALQELNVASNSLTD-----LPGCGAFSS 494

  Fly   816 VTRFYLAHNRLSDIDQLPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCE 880
            ::...:.||.:|...:                       .|.|...|...|...  .||:.|.||
Mouse   495 LSVLVIDHNSVSHPSE-----------------------DFFQSCQNIRSLTAG--NNPFQCTCE 534

  Fly   881 DKDFLVFVKEQAKNIANA--SAIQC----IDTGRSLIEVEETDI-CPSVLIYYTSLAVSLLIIAL 938
            .:||:..:...|:.:...  .:.:|    ...|.:|.:...:.: |.:||:..| :..::|::|:
Mouse   535 LRDFVKNIGWVAREVVEGWPDSYRCDYPESSRGTALRDFHMSPLSCDTVLLTVT-IGATMLVLAV 598

  Fly   939 SINVFIC--FRQPIMIWFYEHEICLSLAAR--------RELDEDKKYDAFLSFTHKDEDLIE-EF 992
            : ..|:|  |..|   | |...:|.....|        .||..:.::.||:|::..|...:: |.
Mouse   599 T-GAFLCLYFDLP---W-YVRMLCQWTQTRHRARHIPLEELQRNLQFHAFVSYSGHDSAWVKNEL 658

  Fly   993 VDRLENGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHAT 1057
            :..||  :...::|.:.|:::.|:||.:.|...::.|.:.|.:::.:|::|.|...|...|.|..
Mouse   659 LPNLE--KDDIQICLHERNFVPGKSIVENIINFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNL 721

  Fly  1058 SRDRCKRLIVVLYPDVEHFDDLDS--ELRAYMVLNTYL----DRNNPN-FWNKLMYSM 1108
            ..:....||::|...:..:....:  :|:..|...|||    ::|... ||..|..|:
Mouse   722 FHEGSDNLILILLAPIPQYSIPTNYHKLKTLMSRRTYLEWPTEKNKHGLFWANLRASI 779

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 LRR 210..>470 CDD:443914 32/114 (28%)
leucine-rich repeat 264..287 CDD:275380
leucine-rich repeat 288..308 CDD:275380
leucine-rich repeat 309..334 CDD:275380
leucine-rich repeat 335..386 CDD:275380 5/25 (20%)
PRK15370 <381..>482 CDD:185268 32/107 (30%)
leucine-rich repeat 388..408 CDD:275380 7/20 (35%)
leucine-rich repeat 412..432 CDD:275378 4/19 (21%)
LRR <416..591 CDD:443914 46/201 (23%)
leucine-rich repeat 433..454 CDD:275378 8/22 (36%)
leucine-rich repeat 455..478 CDD:275378 10/26 (38%)
leucine-rich repeat 479..490 CDD:275378 4/16 (25%)
leucine-rich repeat 632..657 CDD:275378 5/47 (11%)
leucine-rich repeat 658..679 CDD:275378 9/49 (18%)
leucine-rich repeat 680..706 CDD:275378 8/35 (23%)
PCC 684..>771 CDD:188093 13/86 (15%)
leucine-rich repeat 707..719 CDD:275378 3/11 (27%)
leucine-rich repeat 771..791 CDD:275380 5/19 (26%)
PRK15370 <793..>877 CDD:185268 18/86 (21%)
leucine-rich repeat 793..815 CDD:275378 7/24 (29%)
leucine-rich repeat 816..835 CDD:275378 3/18 (17%)
leucine-rich repeat 836..859 CDD:275378 1/22 (5%)
TIR 974..1110 CDD:214587 34/143 (24%)
Tlr1NP_109607.1 LRR <38..>156 CDD:443914 38/151 (25%)
leucine-rich repeat 50..73 CDD:275378 4/22 (18%)
PLN00113 52..>448 CDD:215061 86/475 (18%)
LRR 1 54..77 4/22 (18%)
leucine-rich repeat 74..97 CDD:275378 8/22 (36%)
LRR 2 78..101 7/22 (32%)
leucine-rich repeat 98..118 CDD:275378 8/19 (42%)
LRR 3 102..125 7/22 (32%)
leucine-rich repeat 119..143 CDD:275378 6/52 (12%)
LRR 4 126..150 4/52 (8%)
leucine-rich repeat 144..156 CDD:275378 5/13 (38%)
LRR 5 151..175 8/27 (30%)
LRR 6 176..199 7/23 (30%)
LRR 7 200..223 3/22 (14%)
LRR 8 224..250 2/25 (8%)
LRR 9 251..278 3/26 (12%)
LRR 10 279..308 5/35 (14%)
LRR 11 309..337 1/27 (4%)
Interaction with bacterial lipopeptide. /evidence=ECO:0000250 316..319 0/2 (0%)
LRR 12 338..361 5/22 (23%)
leucine-rich repeat 355..376 CDD:275380 2/20 (10%)
LRR <356..>529 CDD:443914 44/244 (18%)
LRR 13 362..388 5/25 (20%)
leucine-rich repeat 377..402 CDD:275380 5/24 (21%)
LRR 14 389..414 6/24 (25%)
leucine-rich repeat 403..427 CDD:275380 7/25 (28%)
LRR 15 415..437 6/43 (14%)
leucine-rich repeat 428..449 CDD:275380 7/55 (13%)
LRR 16 438..457 5/38 (13%)
leucine-rich repeat 450..472 CDD:275380 5/21 (24%)
LRR 17 458..478 4/19 (21%)
leucine-rich repeat 473..494 CDD:275380 7/25 (28%)
LRR 18 479..500 8/25 (32%)
leucine-rich repeat 495..518 CDD:275380 5/45 (11%)
LRR 19 501..524 7/45 (16%)
LRRCT 527..581 CDD:214507 11/53 (21%)
TIR 639..782 CDD:214587 34/143 (24%)
Blue background indicates that the domain is not in the aligned region.

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