DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-4 and tol-1

DIOPT Version :10

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_001020983.1 Gene:tol-1 / 171635 WormBaseID:WBGene00006593 Length:1221 Species:Caenorhabditis elegans


Alignment Length:1137 Identity:231/1137 - (20%)
Similarity:421/1137 - (37%) Gaps:335/1137 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   247 EKTTLTMEKNIFHGKNKMSALIFNGLKIKGLTNNTFENLTSLNTLIFDNVFLKDLS--------- 302
            ||.:||..:||...:..:.:|  ..|::..:::|...:|....:.:...:.:.|||         
 Worm   149 EKFSLTRSRNIELPQRLLCSL--PHLQVLNISSNELPSLRREESCVAQQLLIVDLSRNRLTNIEQ 211

  Fly   303 FLRS--STLQSSLTY-CIMKVDNMVD---LKSFEKFTNLEIIEVSQYKGFKNFTAFICEPYKSHC 361
            |||.  :..|.|:.| .|.::|..:.   |:..:...| .|::::...|............|   
 Worm   212 FLRGIPAIRQISVAYNSIAELDLSLATPFLQQLDAEAN-RIVDLTSLPGTVVHVNLAGNALK--- 272

  Fly   362 KFTLGINEVACPLKCNCSYNRDK-------SQLEIDCWQKNLTTIPSLPVP-----KKGSSALVF 414
            :....:.|:|..:..|.|.|..:       |..|::....:...:.||||.     :|..:.|..
 Worm   273 RVPDAVAELASLVALNVSRNEIEAGNSSVFSSPELEMLDASYNKLDSLPVEWLQKCEKRIAHLHL 337

  Fly   415 QSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPES------------------------- 454
            :.|.:.:|....|....||::||:|.|||.......|||:                         
 Worm   338 EHNSIEQLTGGVLANATNLQTLDLSSNQLRVFRDEVLPENSKIGNLRLSNNSLELLEPSSLSGLK 402

  Fly   455 LHYLDIRHNKITTLSPQV--VEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLR---IKTS 514
            |..||:.|||:|.:...:  ||.|..|::  .:.....:|  :|.|.     |.|.|.   :..:
 Worm   403 LESLDLSHNKLTEVPAAIGKVEQLKKVDL--SHNRIAKVY--QYVLN-----KIKQLHTVDLSNN 458

  Fly   515 KFQTIMEYIELSSKGSFVENFFVQNIDQLYLEANEDEII--DAFG--PSDKYFNLKL--MEALNH 573
            :.|:|..||       |.::..:.::|   :..||..::  |||.  |..:..::|:  :::|:.
 Worm   459 QLQSIGPYI-------FSDSSELHSLD---VSNNEISLLFKDAFARCPKLRKISMKMNKIKSLDE 513

  Fly   574 AIWLFSG------EFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKT 632
            .:...||      ..:||::              .:|..                 ||.::   .
 Worm   514 GLTEASGLRRLDVSHNEILV--------------LKWSA-----------------LPENL---E 544

  Fly   633 TLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHLLPENITYLDVRNNLLKYLDDGV 697
            .|..|.|:|..|  |.:.:....|::..:.:|.|.:..:....:|.::..|||.||.|..|....
 Worm   545 ILNADNNDINLL--TAASMSPSTANLKSVSLSNNGITIMNADQIPNSLESLDVSNNRLAKLGKTA 607

  Fly   698 IAF------LEYRENI-----------------TKIELSGNPWECNC---------KAKAFLSFL 730
            :|.      |..:.|:                 .|:|:|.||..|:|         |.|..:...
 Worm   608 LAAKSQLRRLNLKGNLLTVVATESMKVVEAVHPLKVEISENPLICDCQMGWMIGGAKPKVLIQDS 672

  Fly   731 R----RHEPMEYETVLRRVEITDDKCP------EDCICCVDTSNSDSLAY--------------- 770
            .    .|....::..::.:...|..||      .:|||| ...|.|..:.               
 Worm   673 ETASCSHAVDGHQIQIQSLSKKDLLCPYKSVCEPECICC-QYGNCDCKSVCPANCRCFRDDQFNI 736

  Fly   771 -VVDCSGKE---------LSE--------------IPQLPTPTY--------------------- 790
             :|.|.|..         :||              :|||.|.::                     
 Worm   737 NIVRCHGNSSMVPKREFVVSELPVSATEIILSGVTLPQLRTHSFIGRLRLQRLHINGTGLRSIQP 801

  Fly   791 -------GQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDI-----DQLPDKLEYLDISN 843
                   ...||....|||.............|::.:|..||.|.:     ::||: |:||.:.|
 Worm   802 KAFHTLPALKTLDLSDNSLISLSGEEFLKCGEVSQLFLNGNRFSTLSRGIFEKLPN-LKYLTLHN 865

  Fly   844 NNFSALDDRVRGFLQKRMNSSQL-QLSLFGNPWTCRC-----------EDKDFLVFVKEQAKN-- 894
            |   :|:|     :.:.::|:.| ::||..||..|.|           .|.....|.:..|..  
 Worm   866 N---SLED-----IPQVLHSTALSKISLSSNPLRCDCSGGSQQHLHHRRDPKAHPFWEHNAAEWF 922

  Fly   895 ------IANASAIQCIDT--------------------GRS--LIEVEE--TDICPSVLIYYTS- 928
                  :.:...::|.:.                    |..  ::.:||  .|...::.:.::| 
 Worm   923 SLHRHLVVDFPKVECWENVTKAFLTNDTTVLSAYPPNMGNDVFVMPIEEFLRDYNSTICVPFSSG 987

  Fly   929 -------LAVSLLIIALSINVFICFRQPIMIWFY--EHEI------------CLSLAARRELDED 972
                   .::..:||.:||.|.:|....:.|.|.  .|:.            |.:.|....|...
 Worm   988 FFGQDPQNSILFVIITISIAVLLCVLVILAISFIRKSHDAINQRRYKASSLNCSTSAGSSPLPVP 1052

  Fly   973 -KKYDAFLSFTHKDEDL-IEEFVDRLENGRHKFRLCFYLRDWLVG-------ESIPDCINQSVKG 1028
             ..|.||:|::.|||.: |::....||:  ..::||...||   |       .:|.|.:...:..
 Worm  1053 LLSYHAFVSYSKKDEKMVIDQLCRPLED--EDYQLCLLHRD---GPTYCSNLHAISDELIAQMDS 1112

  Fly  1029 SRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLDSELRAYMVLNTYL 1093
            |:.:|:::||:||::.|..|:.:.:....:::|.||:|.||...|: .:.||.||...:..:|.:
 Worm  1113 SQCLILVLTKHFLENEWKTLQIKTSHQLFAKNRAKRVIAVLGDGVD-ANLLDDELGQILRKHTRI 1176

  Fly  1094 DRNNPNFWNKLMYSMPHASHLKRSRSDAETKV 1125
            :..:..||..|..|:|....|..:..|..:::
 Worm  1177 EMRSHLFWTLLHSSLPSRLPLPSNSGDDSSQL 1208

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 LRR 210..>470 CDD:443914 60/274 (22%)
leucine-rich repeat 264..287 CDD:275380 4/22 (18%)
leucine-rich repeat 288..308 CDD:275380 6/30 (20%)
leucine-rich repeat 309..334 CDD:275380 6/28 (21%)
leucine-rich repeat 335..386 CDD:275380 8/57 (14%)
PRK15370 <381..>482 CDD:185268 34/139 (24%)
leucine-rich repeat 388..408 CDD:275380 5/24 (21%)
leucine-rich repeat 412..432 CDD:275378 4/19 (21%)
LRR <416..591 CDD:443914 49/216 (23%)
leucine-rich repeat 433..454 CDD:275378 9/20 (45%)
leucine-rich repeat 455..478 CDD:275378 10/24 (42%)
leucine-rich repeat 479..490 CDD:275378 1/10 (10%)
leucine-rich repeat 632..657 CDD:275378 6/24 (25%)
leucine-rich repeat 658..679 CDD:275378 3/20 (15%)
leucine-rich repeat 680..706 CDD:275378 9/31 (29%)
PCC 684..>771 CDD:188093 28/144 (19%)
leucine-rich repeat 707..719 CDD:275378 5/28 (18%)
leucine-rich repeat 771..791 CDD:275380 9/70 (13%)
PRK15370 <793..>877 CDD:185268 25/89 (28%)
leucine-rich repeat 793..815 CDD:275378 5/21 (24%)
leucine-rich repeat 816..835 CDD:275378 7/23 (30%)
leucine-rich repeat 836..859 CDD:275378 7/22 (32%)
TIR 974..1110 CDD:214587 41/143 (29%)
tol-1NP_001020983.1 leucine-rich repeat 71..95 CDD:275380
leucine-rich repeat 96..119 CDD:275380
leucine-rich repeat 120..171 CDD:275380 7/23 (30%)
PLN00113 <166..>460 CDD:215061 64/308 (21%)
leucine-rich repeat 172..195 CDD:275380 3/22 (14%)
leucine-rich repeat 196..283 CDD:275380 17/90 (19%)
leucine-rich repeat 219..240 CDD:275378 5/20 (25%)
leucine-rich repeat 241..258 CDD:275378 3/17 (18%)
leucine-rich repeat 287..306 CDD:275380 4/18 (22%)
leucine-rich repeat 307..331 CDD:275380 4/23 (17%)
leucine-rich repeat 332..355 CDD:275380 4/22 (18%)
LRR 337..653 CDD:443914 77/370 (21%)
leucine-rich repeat 356..379 CDD:275380 10/22 (45%)
leucine-rich repeat 380..395 CDD:275380 0/14 (0%)
leucine-rich repeat 403..425 CDD:275380 8/21 (38%)
leucine-rich repeat 426..449 CDD:275380 6/31 (19%)
leucine-rich repeat 450..473 CDD:275380 6/29 (21%)
leucine-rich repeat 474..497 CDD:275380 6/25 (24%)
leucine-rich repeat 498..520 CDD:275380 2/21 (10%)
leucine-rich repeat 543..567 CDD:275380 6/28 (21%)
leucine-rich repeat 568..589 CDD:275380 3/20 (15%)
leucine-rich repeat 590..613 CDD:275380 8/22 (36%)
leucine-rich repeat 614..633 CDD:275380 2/18 (11%)
leucine-rich repeat 763..785 CDD:275378 4/21 (19%)
LRR <779..>891 CDD:443914 25/120 (21%)
leucine-rich repeat 786..809 CDD:275378 0/22 (0%)
leucine-rich repeat 810..833 CDD:275378 5/22 (23%)
leucine-rich repeat 834..857 CDD:275378 6/22 (27%)
leucine-rich repeat 858..879 CDD:275378 8/28 (29%)
leucine-rich repeat 880..892 CDD:275378 5/11 (45%)
SEFIR 1056..1194 CDD:474043 42/143 (29%)
Blue background indicates that the domain is not in the aligned region.

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