DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-4 and Tlr8

DIOPT Version :10

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_573475.2 Gene:Tlr8 / 170744 MGIID:2176887 Length:1032 Species:Mus musculus


Alignment Length:1170 Identity:264/1170 - (22%)
Similarity:422/1170 - (36%) Gaps:378/1170 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 TSPVFHGWNIFKI--CNETDYELVIISVLGIRS--EVDMRISPAVQYLSLL--GIREISGYDIYL 190
            ||.:||..|..:.  |:|..:..::|:....|.  ||...|...|..:.|.  .|..|: .:.:.
Mouse    21 TSAIFHKANYSRSYPCDEIRHNSLVIAECNHRQLHEVPQTIGKYVTNIDLSDNAITHIT-KESFQ 84

  Fly   191 PSVLITEMDVHH----------ANGPKM----------VTFKYLYDSTVN-------------SV 222
            ....:|::|::|          .||..:          :|...|.|:.:.             |:
Mouse    85 KLQNLTKIDLNHNAKQQHPNENKNGMNITEGALLSLRNLTVLLLEDNQLYTIPAGLPESLKELSL 149

  Fly   223 ITNNYIRKTMNNT------EKIKIYYHNTFE-KTTLTME----KNIFHGKNKMSALIFNGLKIKG 276
            |.||..:.|.|||      |::.:.::..|: ..|..:|    ||:.|            ||:..
Mouse   150 IQNNIFQVTKNNTFGLRNLERLYLGWNCYFKCNQTFKVEDGAFKNLIH------------LKVLS 202

  Fly   277 LTNNTFENLTSLNTLIFDNVFLKDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEKFTNLEIIEVS 341
            |   :|.||                 |.....|.|||.            |.|  .:|.:|:.::
Mouse   203 L---SFNNL-----------------FYVPPKLPSSLR------------KLF--LSNAKIMNIT 233

  Fly   342 Q--YKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPV 404
            |  :||.:|.|.           ..|..|   || :|   ||               ...|..|.
Mouse   234 QEDFKGLENLTL-----------LDLSGN---CP-RC---YN---------------APFPCTPC 265

  Fly   405 PKKGSS----ALVFQS-------NL----LAELPDNSLEGYHNLKSLDVSYNQL-----TSLSVS 449
             |:.||    .|.|||       ||    |..:|....|...|||.|.:.:|.|     :...::
Mouse   266 -KENSSIHIHPLAFQSLTQLLYLNLSSTSLRTIPSTWFENLSNLKELHLEFNYLVQEIASGAFLT 329

  Fly   450 QLPESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTS 514
            :|| ||..||:..|.      |..|||..:|:.:.:....|:  .:.||:.:.:.:     :|..
Mouse   330 KLP-SLQILDLSFNF------QYKEYLQFINISSNFSKLRSL--KKLHLRGYVFRE-----LKKK 380

  Fly   515 KFQTIMEYIELSSKG---SFVE--------NFFVQNIDQLYLEANE-DEIIDAFGPSDKYFNLKL 567
            .|:.:.....|::..   :|:|        ||  ..:|.:||..|. ..::|  |.....:..:|
Mouse   381 HFEHLQSLPNLATINLGINFIEKIDFKAFQNF--SKLDVIYLSGNRIASVLD--GTDYSSWRNRL 441

  Fly   568 MEALNHAIWLFSGEFD-EIILHHLNSPC--PYRCSCC------------------FEWHTGEFLI 611
            .:.|:    ....||| .:..:|...|.  | :|:..                  ||   |...|
Mouse   442 RKPLS----TDDDEFDPHVNFYHSTKPLIKP-QCTAYGKALDLSLNNIFIIGKSQFE---GFQDI 498

  Fly   612 NCRNLSLDIYPRLPN-----SIPYKTTLYL--------DRNEIRKLTNTESLVVAGHA---SI-- 658
            .|.|||.:...::.|     |:|:...|.|        |.|....|.:.|.|.::.:|   ||  
Mouse   499 ACLNLSFNANTQVFNGTEFSSMPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHNAHYFSIAG 563

  Fly   659 --HKLHMSQNL--LRELPL-----HLLPE------------------------------------ 678
              |:|...|||  ||.|.|     :.|.|                                    
Mouse   564 VTHRLGFIQNLINLRVLNLSHNGIYTLTEESELKSISLKELVFSGNRLDRLWNANDGKYWSIFKS 628

  Fly   679 --NITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETV 741
              |:..||:..|.|:.:.:|  |||...:::.::.:|||      |.:.|...|.::.|.     
Mouse   629 LQNLIRLDLSYNNLQQIPNG--AFLNLPQSLQELLISGN------KLRFFNWTLLQYFPH----- 680

  Fly   742 LRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWP 806
                                       .:::|.|..||..:|                |.|.|:.
Mouse   681 ---------------------------LHLLDLSRNELYFLP----------------NCLSKFA 702

  Fly   807 SSLLPGYSSVTRFYLAHNRLSDIDQLPD-------KLEYLDISNNNFSALDDRVRGFLQKRMNSS 864
            .||       ....|:||..|   .||.       .|.:||:|.|....::   :..||.:|.::
Mouse   703 HSL-------ETLLLSHNHFS---HLPSGFLSEARNLVHLDLSFNTIKMIN---KSSLQTKMKTN 754

  Fly   865 QLQLSLFGNPWTCRCEDKDFLVFVKEQAK-NIANASAIQCIDTG----RSLIEVEET----DICP 920
            ...|.|.||.:.|.|:..||..::.|... .|.....:.|.:.|    :|::.::.|    |...
Mouse   755 LSILELHGNYFDCTCDISDFRSWLDENLNITIPKLVNVICSNPGDQKSKSIMSLDLTTCVSDTTA 819

  Fly   921 SVLIYYTSLAVSLLIIALSINVFICFRQPIMIWFYEHEICLSLAARRELDEDKK-YDAFLSFTHK 984
            :||.:.|.|..|::::|..::....:.    :||..|.....|...|.....:. |||::|:..|
Mouse   820 AVLFFLTFLTTSMVMLAALVHHLFYWD----VWFIYHMCSAKLKGYRTSSTSQTFYDAYISYDTK 880

  Fly   985 DED----LIEEFVDRLENGRHK-FRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKST 1044
            |..    :|.|....||....| ..||...|||..|..|.|.:.||:..|::.|.::||.:.||.
Mouse   881 DASVTDWVINELRYHLEESEDKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSW 945

  Fly  1045 WGRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLDSELRAYMVLNTYLD-RNNPN----FWNKL 1104
            ..:..|.|||.....:....:|.:|...|..:... ..||..:..::.|. .|||.    ||..|
Mouse   946 NFKTAFYLALQRLMDENMDVIIFILLEPVLQYSQY-LRLRQRICKSSILQWPNNPKAENLFWQSL 1009

  Fly  1105  1104
            Mouse  1010  1009

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 LRR 210..>470 CDD:443914 72/305 (24%)
leucine-rich repeat 264..287 CDD:275380 6/22 (27%)
leucine-rich repeat 288..308 CDD:275380 1/19 (5%)
leucine-rich repeat 309..334 CDD:275380 6/24 (25%)
leucine-rich repeat 335..386 CDD:275380 13/52 (25%)
PRK15370 <381..>482 CDD:185268 33/120 (28%)
leucine-rich repeat 388..408 CDD:275380 3/19 (16%)
leucine-rich repeat 412..432 CDD:275378 9/30 (30%)
LRR <416..591 CDD:443914 46/203 (23%)
leucine-rich repeat 433..454 CDD:275378 7/25 (28%)
leucine-rich repeat 455..478 CDD:275378 8/22 (36%)
leucine-rich repeat 479..490 CDD:275378 1/10 (10%)
leucine-rich repeat 632..657 CDD:275378 8/35 (23%)
leucine-rich repeat 658..679 CDD:275378 12/69 (17%)
leucine-rich repeat 680..706 CDD:275378 8/25 (32%)
PCC 684..>771 CDD:188093 14/86 (16%)
leucine-rich repeat 707..719 CDD:275378 3/11 (27%)
leucine-rich repeat 771..791 CDD:275380 5/19 (26%)
PRK15370 <793..>877 CDD:185268 23/90 (26%)
leucine-rich repeat 793..815 CDD:275378 5/21 (24%)
leucine-rich repeat 816..835 CDD:275378 6/25 (24%)
leucine-rich repeat 836..859 CDD:275378 6/22 (27%)
TIR 974..1110 CDD:214587 43/142 (30%)
Tlr8NP_573475.2 LRR 1 41..61 4/19 (21%)
LRR 2 62..85 4/23 (17%)
leucine-rich repeat 65..88 CDD:275380 4/23 (17%)
LRR 66..484 CDD:443914 110/521 (21%)
LRR 3 87..109 3/21 (14%)
leucine-rich repeat 89..122 CDD:275380 5/32 (16%)
LRR 4 120..143 3/22 (14%)
leucine-rich repeat 123..143 CDD:275380 3/19 (16%)
leucine-rich repeat 144..167 CDD:275380 8/22 (36%)
LRR 5 145..165 8/19 (42%)
LRR 6 166..194 4/27 (15%)
leucine-rich repeat 168..197 CDD:275380 6/28 (21%)
LRR 7 195..218 9/54 (17%)
leucine-rich repeat 198..218 CDD:275380 8/39 (21%)
leucine-rich repeat 219..242 CDD:275380 8/36 (22%)
LRR 8 220..239 5/32 (16%)
LRR 9 240..267 11/60 (18%)
leucine-rich repeat 243..283 CDD:275380 17/73 (23%)
LRR 10 281..304 4/22 (18%)
leucine-rich repeat 284..307 CDD:275380 5/22 (23%)
LRR 11 306..329 6/22 (27%)
leucine-rich repeat 308..327 CDD:275380 5/18 (28%)
LRR 12 331..360 12/35 (34%)
leucine-rich repeat 334..363 CDD:275380 9/34 (26%)
LRR 13 361..384 5/29 (17%)
leucine-rich repeat 364..390 CDD:275380 4/32 (13%)
LRR 14 388..411 3/22 (14%)
leucine-rich repeat 391..414 CDD:275380 5/24 (21%)
LRR 15 413..436 6/24 (25%)
leucine-rich repeat 465..497 CDD:275380 5/35 (14%)
LRR 16 471..494 2/25 (8%)
LRR_8 501..555 CDD:404697 13/53 (25%)
leucine-rich repeat 501..522 CDD:275380 5/20 (25%)
LRR 17 520..543 5/22 (23%)
leucine-rich repeat 523..546 CDD:275380 5/22 (23%)
LRR <532..791 CDD:443914 69/327 (21%)
LRR 18 545..572 7/26 (27%)
leucine-rich repeat 547..576 CDD:275380 10/28 (36%)
LRR 19 574..598 7/23 (30%)
leucine-rich repeat 577..600 CDD:275380 6/22 (27%)
LRR 20 600..621 0/20 (0%)
leucine-rich repeat 601..631 CDD:275380 0/29 (0%)
LRR 21 629..652 8/24 (33%)
leucine-rich repeat 632..656 CDD:275380 8/25 (32%)
LRR 22 654..677 6/28 (21%)
leucine-rich repeat 657..680 CDD:275380 6/28 (21%)
LRR 23 678..701 8/70 (11%)
leucine-rich repeat 681..704 CDD:275380 8/38 (21%)
LRR 24 702..725 8/32 (25%)
leucine-rich repeat 705..728 CDD:275380 7/32 (22%)
LRR 25 727..749 6/24 (25%)
leucine-rich repeat 729..748 CDD:275380 5/21 (24%)
LRR 26 752..776 8/23 (35%)
TIR 871..1007 CDD:214587 41/136 (30%)

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