DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-4 and TLR6

DIOPT Version :10

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_006059.2 Gene:TLR6 / 10333 HGNCID:16711 Length:796 Species:Homo sapiens


Alignment Length:874 Identity:172/874 - (19%)
Similarity:313/874 - (35%) Gaps:291/874 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   383 DKSQLEIDCWQKNLTTIP-SLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYN--QLT 444
            |.::..:|..::.|..:| .||:..|   .|....|.:|||..:.:.....|..|.:|:|  ||.
Human    30 DGNEFAVDKSKRGLIHVPKDLPLKTK---VLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLL 91

  Fly   445 SLSVSQLPESLHYLDIRHNKITTLS-PQVVEYLY---SVNVF------NQYGNKWSI-------- 491
            .|||.:..:.|.|||:.||::..:| ..:|.:.:   |.|.|      .::||...:        
Human    92 DLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAM 156

  Fly   492 -------------------------YCDEYHLQEFFWYKAKLLRI---KTSKF------------ 516
                                     |..|...:......||.|.:   .||.|            
Human   157 KLQKLDLLPIAHLHLSYILLDLRNYYIKENETESLQILNAKTLHLVFHPTSLFAIQVNISVNTLG 221

  Fly   517 --------------QTIMEYIELSSKGSFVENFFVQNIDQL-----------------YLEANED 550
                          |..::::...::||.:.||.:.:|:..                 ||.....
Human   222 CLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNL 286

  Fly   551 EIIDAFGPSDKYFNLKLMEAL-----NHAIWLFS--------GEFDEIILHHLNSP-----CPYR 597
            .||::....|..::...::||     .:.::|||        .|.:.::|...::|     ||:.
Human   287 TIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHA 351

  Fly   598 CSCCFEWHTGEFLINCRNLSLD-IYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKL 661
            .|      |.:||...:|:..| |:.:....:..: ||.|.:|.::.|... .|:.....|:..|
Human   352 PS------TFKFLNFTQNVFTDSIFEKCSTLVKLE-TLILQKNGLKDLFKV-GLMTKDMPSLEIL 408

  Fly   662 HMSQNLLRELPLHLLPENITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWECNCKAKAF 726
            .:|.|.| |...|  .||.|::                     |:|..:.||.|           
Human   409 DVSWNSL-ESGRH--KENCTWV---------------------ESIVVLNLSSN----------- 438

  Fly   727 LSFLRRHEPMEYETVLR----RVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIPQLPT 787
                     |..::|.|    |::                        |:|....::..:|:...
Human   439 ---------MLTDSVFRCLPPRIK------------------------VLDLHSNKIKSVPKQVV 470

  Fly   788 PTYGQTTLVFERNSLKKWPSSLLPG---YSSVTRFYLAHNRLS----DIDQLPDKLEYLDISNNN 845
            .......|....|||..     |||   :||::...:.||.:|    |..|...|:..:...:  
Human   471 KLEALQELNVAFNSLTD-----LPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGD-- 528

  Fly   846 FSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANAS---------AI 901
                                       ||:.|.||.::|:       |||...|         :.
Human   529 ---------------------------NPFQCTCELREFV-------KNIDQVSSEVLEGWPDSY 559

  Fly   902 QCID-----TGRSLIEVEETDICPSVLIYYTSLAVSLLIIALSINVFICFRQPIMIWFYEHEICL 961
            :| |     .|..|.:...:::..::.:...::..::|::|:::.....:..  :.| |...:|.
Human   560 KC-DYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLAVTVTSLCIYLD--LPW-YLRMVCQ 620

  Fly   962 SLAARR--------ELDEDKKYDAFLSFTHKDEDLIE-EFVDRLENGRHKFRLCFYLRDWLVGES 1017
            ....||        ||..:.::.||:|::..|...:: |.|..||  :...::|.:.|:::.|:|
Human   621 WTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSELVPYLE--KEDIQICLHERNFVPGKS 683

  Fly  1018 IPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVL--------YPDVE 1074
            |.:.|...::.|.:.|.:::.||::|.|...|...|.|....:....||::|        .|:..
Human   684 IVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKY 748

  Fly  1075 HFDDLDSELRAYMVLNTYLDRNNPNFWNK 1103
            |      :|:|.|...|||.      |.|
Human   749 H------KLKALMTQRTYLQ------WPK 765

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 LRR 210..>470 CDD:443914 28/90 (31%)
leucine-rich repeat 264..287 CDD:275380
leucine-rich repeat 288..308 CDD:275380
leucine-rich repeat 309..334 CDD:275380
leucine-rich repeat 335..386 CDD:275380 1/2 (50%)
PRK15370 <381..>482 CDD:185268 31/105 (30%)
leucine-rich repeat 388..408 CDD:275380 5/20 (25%)
leucine-rich repeat 412..432 CDD:275378 5/19 (26%)
LRR <416..591 CDD:443914 52/278 (19%)
leucine-rich repeat 433..454 CDD:275378 9/22 (41%)
leucine-rich repeat 455..478 CDD:275378 8/26 (31%)
leucine-rich repeat 479..490 CDD:275378 4/16 (25%)
leucine-rich repeat 632..657 CDD:275378 6/24 (25%)
leucine-rich repeat 658..679 CDD:275378 6/20 (30%)
leucine-rich repeat 680..706 CDD:275378 1/25 (4%)
PCC 684..>771 CDD:188093 9/90 (10%)
leucine-rich repeat 707..719 CDD:275378 4/11 (36%)
leucine-rich repeat 771..791 CDD:275380 3/19 (16%)
PRK15370 <793..>877 CDD:185268 17/90 (19%)
leucine-rich repeat 793..815 CDD:275378 7/24 (29%)
leucine-rich repeat 816..835 CDD:275378 5/22 (23%)
leucine-rich repeat 836..859 CDD:275378 0/22 (0%)
TIR 974..1110 CDD:214587 36/139 (26%)
TLR6NP_006059.2 leucine-rich repeat 36..53 CDD:275380 5/16 (31%)
leucine-rich repeat 54..77 CDD:275378 6/25 (24%)
LRR 1 54..77 6/25 (24%)
LRR <55..327 CDD:443914 52/274 (19%)
leucine-rich repeat 78..101 CDD:275378 9/22 (41%)
LRR 2 78..101 9/22 (41%)
leucine-rich repeat 102..122 CDD:275378 7/19 (37%)
LRR 3 102..122 7/19 (37%)
leucine-rich repeat 123..147 CDD:275378 5/23 (22%)
LRR 4 123..147 5/23 (22%)
LRR 5 148..168 0/19 (0%)
leucine-rich repeat 148..161 CDD:275378 0/12 (0%)
LRR 6 169..196 2/26 (8%)
leucine-rich repeat 174..196 CDD:275380 2/21 (10%)
LRR 7 197..219 5/21 (24%)
LRR 8 220..250 2/29 (7%)
LRR 249..>531 CDD:443914 70/391 (18%)
LRR 9 251..277 3/25 (12%)
LRR 10 278..303 5/24 (21%)
LRR 11 304..330 5/25 (20%)
LRR 12 331..354 5/28 (18%)
LRR 13 355..378 5/22 (23%)
leucine-rich repeat 379..404 CDD:275380 6/26 (23%)
LRR 14 379..404 6/26 (23%)
leucine-rich repeat 405..429 CDD:275380 9/47 (19%)
LRR 15 405..429 9/47 (19%)
leucine-rich repeat 430..451 CDD:275380 7/40 (18%)
LRR 16 430..450 7/39 (18%)
LRR 17 451..474 4/46 (9%)
leucine-rich repeat 452..474 CDD:275380 3/45 (7%)
leucine-rich repeat 475..497 CDD:275380 8/26 (31%)
LRR 18 475..496 7/25 (28%)
LRR 19 497..520 5/22 (23%)
leucine-rich repeat 499..520 CDD:275380 5/20 (25%)
LRRCT 529..582 CDD:214507 14/60 (23%)
TIR 641..780 CDD:214587 36/139 (26%)
Blue background indicates that the domain is not in the aligned region.

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