DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-zeta and Ntm

DIOPT Version :9

Sequence 1:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	XP_017451354.1	Gene:	Ntm / 50864	RGDID:	620958	Length:	367	Species:	Rattus norvegicus

Alignment Length:	329	Identity:	104/329 - (31%)
Similarity:	155/329 - (47%)	Gaps:	37/329 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 GVIVAGGGANVPTSNLNIVVEEPEFTEYIENVTVPAGRNVKLGCSVKNLGSYKVAWMHFEQSAIL 155
            ||.|..|.|..|.:              ::||||..|.:..|.|::.|..: :|||::  :|.||
  Rat    28 GVPVRSGDATFPKA--------------MDNVTVRQGESATLRCTIDNRVT-RVAWLN--RSTIL 75

  Fly   156 TVHNHVITRNPRISVTHDKHDRHRTWYLHINNVHEEDRGRYMCQINTVT-AKTQFGYLNVVVPPN 219
            ...|.....:||:.:..:...::.   :.|.||...|.|.|.|.:.|.. .||...:|.|.|.|.
  Rat    76 YAGNDKWCLDPRVVLLSNTQTQYS---IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPK 137

  Fly   220 IDDSLSSSDVIVREGANISLRCRASGSPRPIIKWKRDDNSRIAINKNHIVNEWEGDTLEITRISR 284
            |.:  .|||:.:.||.||||.|.|:|.|.|.:.|:.       |:...:....|.:.|||..|:|
  Rat   138 IVE--ISSDISINEGNNISLTCIATGRPEPTVTWRH-------ISPKAVGFVSEDEYLEIQGITR 193

  Fly   285 LDMGAYLCIASNGVPPTVSKRIKVSVDFPPMLLIPHQLVGAPEGFNVTIECFTEAHPTSLNYWTR 349
            ...|.|.|.|||.|...|.:|:||:|::|| .:...:..|.|.|...|::|...|.|::...|.:
  Rat   194 EQSGEYECSASNDVAAPVVRRVKVTVNYPP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWFK 257

  Fly   350 GEGPIIHDSHKYKVEATVGLPAYKTHMKLTIINVSSGDDGIYKCVAKNPRGETDGIIRLYVSYPP 414
            .:..::......|||....|      .:||..|||..|.|.|.|||.|..|.|:..|.|:....|
  Rat   258 DDKRLVEGKKGVKVENRPFL------SRLTFFNVSEHDYGNYTCVASNKLGHTNASIMLFELNEP 316

  Fly   415 TTAS 418
            |:::
  Rat   317 TSST 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	29/96 (30%)
		Ig	130..200	CDD:143165	19/69 (28%)
		I-set	226..310	CDD:254352	33/83 (40%)
		IGc2	233..298	CDD:197706	25/64 (39%)
		Ig	313..410	CDD:299845	30/96 (31%)
		IG_like	325..410	CDD:214653	27/84 (32%)
Ntm	XP_017451354.1	Ig	44..132	CDD:416386	28/93 (30%)
		Ig strand A'	44..49	CDD:409353	4/4 (100%)
		Ig strand B	51..59	CDD:409353	2/7 (29%)
		CDR1	59..63	CDD:409353	1/3 (33%)
		FR2	64..70	CDD:409353	3/6 (50%)
		Ig strand C	64..70	CDD:409353	3/6 (50%)
		CDR2	71..83	CDD:409353	4/11 (36%)
		Ig strand C'	72..76	CDD:409353	2/3 (67%)
		Ig strand C'	80..83	CDD:409353	0/2 (0%)
		FR3	84..118	CDD:409353	9/36 (25%)
		Ig strand D	87..94	CDD:409353	1/6 (17%)
		Ig strand E	97..103	CDD:409353	0/8 (0%)
		Ig strand F	110..118	CDD:409353	3/7 (43%)
		CDR3	119..123	CDD:409353	1/3 (33%)
		Ig strand G	123..132	CDD:409353	3/8 (38%)
		FR4	125..132	CDD:409353	2/6 (33%)
		Ig_3	136..205	CDD:404760	28/77 (36%)
		Ig strand A'	144..148	CDD:409353	1/3 (33%)
		Ig strand B	151..160	CDD:409353	5/8 (63%)
		Ig strand F	197..205	CDD:409353	4/7 (57%)
		Ig	223..307	CDD:416386	27/90 (30%)
		putative Ig strand A	223..229	CDD:409353	1/6 (17%)
		Ig strand B	239..243	CDD:409353	1/3 (33%)
		Ig strand C	252..256	CDD:409353	0/3 (0%)
		Ig strand E	278..282	CDD:409353	1/3 (33%)
		Ig strand F	292..297	CDD:409353	2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337186
Domainoid	1	1.000	50	1.000	Domainoid score	I11360
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41139
Inparanoid	1	1.050	142	1.000	Inparanoid score	I4382
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8971
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.900