DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-zeta and negr1

DIOPT Version :9

Sequence 1:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	XP_009300786.1	Gene:	negr1 / 445374	ZFINID:	ZDB-GENE-040822-27	Length:	360	Species:	Danio rerio

Alignment Length:	335	Identity:	102/335 - (30%)
Similarity:	150/335 - (44%)	Gaps:	51/335 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 EFTEYIENVTVPAGRNVKLGCSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDRH 178
            ::|...|:|....|....|.|.:.: |..|.||::  :|:|:...|...:.:||:|:..:..|:|
Zfish    39 DYTTSSESVVSRQGDTALLRCYLLD-GISKGAWLN--RSSIIYAGNDKWSGDPRVSIVSNVGDKH 100

  Fly   179 RTWYLHINNVHEEDRGRYMCQINTV-TAKTQFGYLNVVVPPNIDDSLSSSDVIVREGANISLRCR 242
            . :.|.|..|...|.|.|.|.|.:. ....:...|.|.|||.|.|  .|||:.|.||:|:||.|.
Zfish   101 E-YSLQIQKVDVTDEGVYTCSIQSERNLHPKLIQLIVKVPPKIYD--ISSDITVNEGSNVSLICA 162

  Fly   243 ASGSPRPIIKWKRDDNSRIAINKNHI---VNEWE-GDTLEITRISRLDMGAYLCIASNGVPPTVS 303
            |||.|.|.|.|:            ||   ..::| |:.|.||.|||...|.|.|.|.|.:....:
Zfish   163 ASGKPEPKISWR------------HISPSARKYESGEYLNITGISRDQAGDYECGAENDIASPDT 215

  Fly   304 KRIKVSVDFPPMLLIPHQLV--GAPEGFNVTIECFTEAHPTSLNYWTRGE-------GPIIHDSH 359
            |.::|:|:|||.:   |::.  |...|....:.|...|.|:.:..|.:||       |.:|::..
Zfish   216 KTVRVTVNFPPAI---HEMKSHGVRPGQVALLRCEAAAVPSPVFEWYKGEKRINMGQGIVINNLS 277

  Fly   360 KYKVEATVGLPAYKTHMKLTIINVSSGDDGIYKCVAKNPRGETDGIIRLYVSYPPTTAS--SGIY 422
            ...|              ||:.|::....|.|.|||.|..|..:..:.|.....|||.|  |...
Zfish   278 SRSV--------------LTVKNMTQDRYGNYTCVAVNRLGTANASVPLNPIIEPTTTSAVSSPA 328

  Fly   423 STDTHWGENG 432
            |....:|..|
Zfish   329 SNPAMYGSTG 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	27/96 (28%)
		Ig	130..200	CDD:143165	21/69 (30%)
		I-set	226..310	CDD:254352	34/87 (39%)
		IGc2	233..298	CDD:197706	28/68 (41%)
		Ig	313..410	CDD:299845	25/105 (24%)
		IG_like	325..410	CDD:214653	21/91 (23%)
negr1	XP_009300786.1	Ig	42..121	CDD:299845	24/82 (29%)
		IG_like	44..136	CDD:214653	26/95 (27%)
		I-set	140..222	CDD:254352	37/95 (39%)
		IGc2	153..208	CDD:197706	27/66 (41%)
		IG_like	236..312	CDD:214653	20/89 (22%)
		IGc2	238..304	CDD:197706	19/79 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576312
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		otm26286
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6406
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.780