DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-zeta and DIP-eta

DIOPT Version :9

Sequence 1:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster

Alignment Length:	435	Identity:	169/435 - (38%)
Similarity:	243/435 - (55%)	Gaps:	62/435 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 VVEEPEFTEYIENVTVPAGRNVKLGCSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHD 173
            |:.:|:|:..|.|:|.|.||:..|.|.|::||.|||||:..:...|||:.|||||:|.||.:.:.
  Fly    39 VIVDPKFSSPIVNMTAPVGRDAFLTCVVQDLGPYKVAWLRVDTQTILTIQNHVITKNQRIGIANS 103

  Fly   174 KHDRHRTWYLHINNVHEEDRGRYMCQINTVTAKTQFGYLNVVVPPNIDDSLSSSDVIVREGANIS 238
            :   |:||.:.|.::.|.|:|.|||||||...|:|.|||:|||||:|.|..:|:|::||||:|::
  Fly   104 E---HKTWTMRIKDIKESDKGWYMCQINTDPMKSQMGYLDVVVPPDILDYPTSTDMVVREGSNVT 165

  Fly   239 LRCRASGSPRPIIKWKRDDNSRIAINKNHIVNEWEGDTLEITRISRLDMGAYLCIASNGVPPTVS 303
            |:|.|:|||.|.|.|:|:....|.:.....|...||..|.|..:.|..||||||||||||||:||
  Fly   166 LKCAATGSPEPTITWRRESGVPIELATGEEVMSIEGTDLVIPNVRRHHMGAYLCIASNGVPPSVS 230

  Fly   304 KRIKVSVDFPPMLLIPHQLVGAPEGFNVTIECFTEAHPTSLNYWTRGEGPIIHDSHKYKVEAT-V 367
            |||.:.|.||||:.:.:||:||.||..||::|.:||:|.|:|||||..|.|:....||....| :
  Fly   231 KRITLVVHFPPMITVQNQLIGAVEGKGVTLDCESEAYPKSINYWTRERGEIVPPGGKYSANVTEI 295

  Fly   368 GLPAYKTHMKLTIINVSSGDDGIYKCVAKNPRGETDGIIRLYVSYPPTTASSGIYSTDTHWGENG 432
            |  .|:..|:|.|..::..:.|.|:|||||..|:|||.|:|| ..||                |.
  Fly   296 G--GYRNSMRLHINPLTQAEFGSYRCVAKNSLGDTDGTIKLY-RIPP----------------NA 341

  Fly   433 INNNYAYGGPDSTRSIYAQDKNTRYQSNLNEIGLSEQKSFLDKTQNPLLANGNANEADAESNGAR 497
            :|              |.::...|::      |....||  .::.:|..|..::.| |.|:.|.|
  Fly   342 VN--------------YVENFEARHK------GKKRTKS--SESHHPARAQEHSGE-DMENPGKR 383

  Fly   498 GHNPSMAIAWLFVV----------------IATLLLTIRSAVGSS 526
            ..:.|:....:..:                :..|||.:..||..|
  Fly   384 KADLSLGAESIDSIYGNSAAGSRRRQDLGGVLLLLLPVAVAVAMS 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	46/95 (48%)
		Ig	130..200	CDD:143165	31/69 (45%)
		I-set	226..310	CDD:254352	43/83 (52%)
		IGc2	233..298	CDD:197706	30/64 (47%)
		Ig	313..410	CDD:299845	44/97 (45%)
		IG_like	325..410	CDD:214653	38/85 (45%)
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	45/92 (49%)
		IG_like	51..137	CDD:214653	42/88 (48%)
		IG_like	153..237	CDD:214653	43/83 (52%)
		Ig	161..224	CDD:299845	28/62 (45%)
		IG_like	252..335	CDD:214653	37/84 (44%)
		Ig	258..333	CDD:143165	33/76 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442843
Domainoid	1	1.000	48	1.000	Domainoid score	I11903
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4644
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102333at6960
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		otm26286
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
	10	9.900