DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-zeta and itgb4

DIOPT Version :9

Sequence 1:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	XP_005166847.1	Gene:	itgb4 / 335269	ZFINID:	ZDB-GENE-030131-7209	Length:	1931	Species:	Danio rerio

Alignment Length:	374	Identity:	71/374 - (18%)
Similarity:	127/374 - (33%)	Gaps:	113/374 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 AGSGTGSTVVGSNGVIVAGGGANVPTSNLNIVVEEPEFTEYI-----ENVTVPAGRNVKLGCSVK 137
            ||....|.::.||.|:      ..|||:|...|.:....:::     :|...|.|..   |...:
Zfish  1450 AGEEYDSYLMYSNEVL------RSPTSSLRPSVTDLSDDQFVNGKWEQNFLFPGGGG---GSLSR 1505

  Fly   138 NLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDRHRTWYL--------HINNVHE---- 190
            |:.|....:.|               ..||.:||::.   ..|.|:        |..:|.:
Zfish  1506 NISSSSTTYSH---------------STPRTNVTNNS---STTTYISGKGGSTTHRYDVRDGGLL 1552

  Fly   191 -ED-------RGRYMCQINTVTAKTQFGYLNVVVPPNIDDSLSSSDVIVREGANISLRCRASGSP 247
             ||       ..|:..:.:.|......|.|:    ..:.|:|..|........:.||..||
Zfish  1553 KEDVILRKRSENRHYTEGDGVRDSIVMGNLS----GGLLDNLGVSSFSQTTSTSYSLSSRA---- 1609

  Fly   248 RPIIKWKRDDNSRIAINKNHIVNEWEGDTLEITRISRLDMGAYLCIASNGVPPTVSKRIKVSVDF 312
                :.:.:|.:...:|.:.::.|           ||.         :.|||.|
Zfish  1610 ----RTQSEDINDALLNLDSVLQE-----------SRF---------TPGVPAT----------- 1639

  Fly   313 PPMLLIPHQLVGAPEGFNVTIECFTEAHPTS--LNYWTRGEGPIIHDSHKYKVEATVGLPAYKTH 375
                  |.:||.:..|.......:.|.|..|  |.|....:  :|:.....::|  |..||..:
Zfish  1640 ------PSRLVFSALGHTALKVSWQEPHCESDVLGYCVLYQ--LINGGDVKRIE--VNNPAQNS- 1693

  Fly   376 MKLTIINVSSGDDGIYKCVAKNPRG---ETDGIIRLYVSYPPTTASSGI 421
              :.:.::......|:|..|::..|   |.:|:|.:..:..|.:..|.:
Zfish  1694 --VLVQDLLPNQSYIFKVKAQSREGWGPEREGVITIESNVDPKSPLSPV 1740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	21/115 (18%)
		Ig	130..200	CDD:143165	15/89 (17%)
		I-set	226..310	CDD:254352	14/83 (17%)
		IGc2	233..298	CDD:197706	9/64 (14%)
		Ig	313..410	CDD:299845	21/101 (21%)
		IG_like	325..410	CDD:214653	18/89 (20%)
itgb4	XP_005166847.1	Integrin_beta	37..457	CDD:278776
		EGF_2	<468..490	CDD:285248
		EGF_2	545..573	CDD:285248
		Integrin_B_tail	625..709	CDD:285239
		Calx-beta	991..1064	CDD:295344
		FN3	1242..1326	CDD:238020
		FN3	1331..1420	CDD:238020
		fn3	1640..1720	CDD:278470	18/86 (21%)
		fn3	1751..1835	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900