DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-zeta and Igsf9

DIOPT Version :9

Sequence 1:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001100667.1	Gene:	Igsf9 / 304982	RGDID:	1304566	Length:	1179	Species:	Rattus norvegicus

Alignment Length:	335	Identity:	84/335 - (25%)
Similarity:	141/335 - (42%)	Gaps:	55/335 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 EPEFTEYIENVTVPAGRNVKLGCSVKNLGS----YKVAWMHFEQSAILTVHNHVITRNPRISVTH 172
            :||    :.:|...||.:..|||.:.....    :.:.|:.|  ..:|.:.......:|||...:
  Rat    23 KPE----VVSVVGRAGESAVLGCDLLPPAGRPPLHVIEWLRF--GFLLPIFIQFGLYSPRIDPDY 81

  Fly   173 DKHDRHRTW-YLHINNVHEEDRGRYMCQINTVT--------AKTQFGYLNVVVPPNIDDSLSSSD 228
            ....|.:|. .|.|..:..||:|.|.|::..:.        |...:.:|.|..||...:: ....
  Rat    82 VGRVRLQTGASLQIEGLRVEDQGWYECRVLFLDQHSPEQDFANGSWVHLTVNSPPQFQET-PPLV 145

  Fly   229 VIVREGANISLRCRASGSPRPIIKWK-RDDNSRIAINKNHIVNEWEGDTLEITRISRLDMGAYLC 292
            :.|:|...::|||.|.|||:|.:.|| |..:    :.|.....:....||.|.|:.|...|.|.|
  Rat   146 LEVKELEAVTLRCVALGSPQPYVTWKFRGQD----LGKGQGQVQVRNGTLWIRRVERGSAGDYTC 206

  Fly   293 IASNGVPPTVSKRIKVSVDFPPMLLIP--HQLVGAPEGFNVTIECFTEAHPTSLNY-WTRGEGPI 354
            .||: ...:|:...::.|..||::::|  :..|.|.:  :|::.|..||:|.:|.| |.:....:
  Rat   207 QASS-TEGSVTHTTQLLVLGPPVIVVPPNNNTVNASQ--DVSLACRAEAYPANLTYSWFQDRINV 268

  Fly   355 IHDSH-----KYKVEATVGLPAYKTHMKLTIINVSSGDDGIYKCVAKN----PRGETDGIIRLYV 410
            .|.|.     :..|:.::.|.|           ....|.|.|.||..|    |...:..:..||.
  Rat   269 FHISRLQSRVRILVDGSLWLQA-----------TQPDDAGHYTCVPSNGFPHPPSASAYLTVLYP 322

  Fly   411 S----YPPTT 416
            :    .||.|
  Rat   323 AQVTVMPPET 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	24/108 (22%)
		Ig	130..200	CDD:143165	18/74 (24%)
		I-set	226..310	CDD:254352	25/84 (30%)
		IGc2	233..298	CDD:197706	23/65 (35%)
		Ig	313..410	CDD:299845	26/108 (24%)
		IG_like	325..410	CDD:214653	22/94 (23%)
Igsf9	NP_001100667.1	IG	28..110	CDD:214652	21/83 (25%)
		Ig strand A	136..139	CDD:409353	1/2 (50%)
		IG_like	143..223	CDD:214653	25/84 (30%)
		Ig strand A'	145..148	CDD:409353	0/2 (0%)
		Ig strand B	154..161	CDD:409353	3/6 (50%)
		Ig strand C	167..172	CDD:409353	1/4 (25%)
		Ig strand C'	175..177	CDD:409353	0/5 (0%)
		Ig strand D	183..187	CDD:409353	0/3 (0%)
		Ig strand E	189..193	CDD:409353	2/3 (67%)
		Ig strand F	202..210	CDD:409353	4/7 (57%)
		Ig strand G	213..223	CDD:409353	1/9 (11%)
		Ig_3	226..305	CDD:404760	23/91 (25%)
		putative Ig strand A	226..230	CDD:409353	2/3 (67%)
		putative Ig strand A'	235..239	CDD:409353	0/3 (0%)
		putative Ig strand B	241..251	CDD:409353	2/11 (18%)
		putative Ig strand C'	267..270	CDD:409353	0/2 (0%)
		putative Ig strand D	279..282	CDD:409353	0/2 (0%)
		putative Ig strand E	284..290	CDD:409353	1/5 (20%)
		putative Ig strand F	297..305	CDD:409353	4/7 (57%)
		putative Ig strand G	310..319	CDD:409353	1/8 (13%)
		Ig	322..407	CDD:416386	3/11 (27%)
		Ig strand A'	324..328	CDD:409353	0/3 (0%)
		Ig strand B	333..347	CDD:409353	84/335 (25%)
		Ig strand C	353..359	CDD:409353
		Ig strand C'	362..364	CDD:409353
		Ig strand D	371..374	CDD:409353
		Ig strand E	378..382	CDD:409353
		Ig strand F	391..399	CDD:409353
		Ig	418..503	CDD:416386
		Ig strand A	418..421	CDD:409353
		Ig strand A'	427..430	CDD:409353
		Ig strand B	436..443	CDD:409353
		Ig strand C	449..454	CDD:409353
		Ig strand C'	457..459	CDD:409353
		Ig strand D	462..466	CDD:409353
		Ig strand E	469..473	CDD:409353
		Ig strand F	482..490	CDD:409353
		Ig strand G	493..503	CDD:409353
		FN3	508..599	CDD:238020
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..807
		PHA03247	<777..1062	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..846
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..895
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..979
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000