DRSC/TRiP Functional Genomics Resources

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Protein Alignment DIP-zeta and NEGR1

DIOPT Version :10

Sequence 1:NP_723441.2 Gene:DIP-zeta / 34231 FlyBaseID:FBgn0051708 Length:532 Species:Drosophila melanogaster
Sequence 2:NP_776169.2 Gene:NEGR1 / 257194 HGNCID:17302 Length:354 Species:Homo sapiens


Alignment Length:305 Identity:95/305 - (31%)
Similarity:144/305 - (47%) Gaps:29/305 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   119 IENVTVPAGRNVKLGCSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISV-THDKHDRHRTWY 182
            ::|:.|..|....|.|.::: |:.|.||::  :|:|:.......:.:||:|: |.:|.|    :.
Human    45 VDNMMVRKGDTAVLRCYLED-GASKGAWLN--RSSIIFAGGDKWSVDPRVSISTLNKRD----YS 102

  Fly   183 LHINNVHEEDRGRYMCQINTV-TAKTQFGYLNVVVPPNIDDSLSSSDVIVREGANISLRCRASGS 246
            |.|.||...|.|.|.|.:.|. |.:|...:|.|.|||.|.|  .|:|:.|.||.|::|.|.|:|.
Human   103 LQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYD--ISNDMTVNEGTNVTLTCLATGK 165

  Fly   247 PRPIIKWKRDDNSRIAINKNHIVNEWEGDTLEITRISRLDMGAYLCIASNGVPPTVSKRIKVSVD 311
            |.|.|.|:     .|:.:.....|   |..|:|..|:|...|.|.|.|.|.|.....:::||.|:
Human   166 PEPSISWR-----HISPSAKPFEN---GQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVN 222

  Fly   312 FPPMLLIPHQLVGAPEGFNVTIECFTEAHPTSLNYWTRGEGPIIHDSHKYKVEATVGLPAYKTHM 376
            |.|.:.........| |.:..|.|.....|.....|.:||..:      :..:..:.:..:.|..
Human   223 FAPTIQEIKSGTVTP-GRSGLIRCEGAGVPPPAFEWYKGEKKL------FNGQQGIIIQNFSTRS 280

  Fly   377 KLTIINVSSGDDGIYKCVAKNPRGETDGIIRLYVSYPPTTASSGI 421
            .||:.||:....|.|.|||.|..|.|:..:.|   .||:||..||
Human   281 ILTVTNVTQEHFGNYTCVAANKLGTTNASLPL---NPPSTAQYGI 322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIP-zetaNP_723441.2 IG_like 120..216 CDD:214653 30/97 (31%)
Ig strand B 130..134 CDD:409405 1/3 (33%)
Ig strand C 143..147 CDD:409405 2/3 (67%)
Ig strand E 178..185 CDD:409405 1/6 (17%)
IgI_1_MuSK 218..310 CDD:409562 32/91 (35%)
Ig strand A 218..221 CDD:409562 1/2 (50%)
Ig strand A' 226..231 CDD:409562 2/4 (50%)
Ig strand B 237..244 CDD:409562 2/6 (33%)
Ig strand C 250..255 CDD:409562 2/4 (50%)
Ig strand C' 257..259 CDD:409562 0/1 (0%)
Ig strand D 267..270 CDD:409562 0/2 (0%)
Ig strand E 275..281 CDD:409562 2/5 (40%)
Ig strand F 288..295 CDD:409562 3/6 (50%)
Ig strand G 302..310 CDD:409562 2/7 (29%)
IG_like 325..410 CDD:214653 22/84 (26%)
Ig strand B 331..335 CDD:143207 1/3 (33%)
Ig strand C 344..348 CDD:143207 0/3 (0%)
Ig strand E 376..380 CDD:143207 1/3 (33%)
Ig strand F 390..395 CDD:143207 2/4 (50%)
Ig strand G 403..406 CDD:143207 0/2 (0%)
NEGR1NP_776169.2 IG_like 47..135 CDD:214653 29/94 (31%)
Ig strand B 56..60 CDD:409353 1/3 (33%)
Ig strand C 68..72 CDD:409353 2/3 (67%)
Ig strand E 101..105 CDD:409353 1/3 (33%)
Ig strand F 115..120 CDD:409353 2/4 (50%)
Ig strand G 128..131 CDD:409353 1/2 (50%)
Ig_3 138..207 CDD:464046 29/78 (37%)
IG_like 231..312 CDD:214653 21/87 (24%)
Ig strand B 241..245 CDD:409353 1/3 (33%)
Ig strand C 254..258 CDD:409353 0/3 (0%)
Ig strand E 280..284 CDD:409353 1/3 (33%)
Ig strand F 294..299 CDD:409353 2/4 (50%)

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