DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-zeta and IGSF9B

DIOPT Version :9

Sequence 1:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens

Alignment Length:	401	Identity:	99/401 - (24%)
Similarity:	151/401 - (37%)	Gaps:	99/401 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 STVVGSNGVIVAGGGANVPTSNLNIVVEEPEFTEYIENVTVPAGRNVKLGCSVKN--LGS---YK 143
            ::|:|:.|:...|...         :.|||||      ||..||.:|.|.|.|.:  .|.   |.
Human    10 ASVIGTRGLAAEGAHG---------LREEPEF------VTARAGESVVLRCDVIHPVTGQPPPYV 59

  Fly   144 VAWMHFEQSAILTVH-----NHVITRNPRISVTHDKHDRHRTWYLHINNVHEEDRGRYMCQINTV 203
            |.|..|.....:.:.     .||   :|..:.....||:..   |.:..|..||:|.|.|::  :
Human    60 VEWFKFGVPIPIFIKFGYYPPHV---DPEYAGRASLHDKAS---LRLEQVRSEDQGWYECKV--L 116

  Fly   204 TAKTQFG--------YLNVVVPPNIDDSLSSSDVIVREGANISLRCRASGSPRPIIKWKRDDNSR 260
            ....|:.        :|.:..||...:: ....:..:||.:|::.|.|.|:|:||:.|.::....
Human   117 MLDQQYDTFHNGSWVHLTINAPPTFTET-PPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLL 180

  Fly   261 IAINKNHIVNEWEGDTLEITRISRLDMGAYLC----IASNGVPPTVSKRIKVSVDFPPMLLIPHQ 321
            .|..|..:    ...:|.:|.:||.|.|||.|    |....|..|     .:.|..||.::.|
Human   181 GASGKYQV----SDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTT-----HLLVQGPPFIVSP-- 234

  Fly   322 LVGAPEGFNVTIE------CFTEAHPTSLN---YWTRGEGPIIHDSHKYKVEATVGLPAYKTHMK 377
                ||...|.|.      |..||:|.:|.   || :.|.....:..|.:|...:       ...
Human   235 ----PENITVNISQDALLTCRAEAYPGNLTYTWYW-QDENVYFQNDLKLRVRILI-------DGT 287

  Fly   378 LTIINVSSGDDGIYKCVAKNPRGET-DGIIRLYVSYPPTTASS--------GIY----------- 422
            |.|..|...|.|.|.||..|..|.: .....|.|.||....:.        ||:
Human   288 LIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEP 352

  Fly   423 -STDTHWGENG 432
             :|...|.::|
Human   353 PATVVKWNKDG 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	27/113 (24%)
		Ig	130..200	CDD:143165	21/79 (27%)
		I-set	226..310	CDD:254352	24/87 (28%)
		IGc2	233..298	CDD:197706	22/68 (32%)
		Ig	313..410	CDD:299845	28/106 (26%)
		IG_like	325..410	CDD:214653	25/94 (27%)
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653	28/96 (29%)
		Ig	41..115	CDD:143165	21/79 (27%)
		I-set	139..225	CDD:254352	25/95 (26%)
		IGc2	153..210	CDD:197706	21/60 (35%)
		I-set	229..321	CDD:254352	27/105 (26%)
		Ig	235..321	CDD:299845	25/93 (27%)
		IG_like	331..414	CDD:214653	5/33 (15%)
		Ig	<353..414	CDD:299845	3/11 (27%)
		IG_like	426..505	CDD:214653
		Ig	442..505	CDD:299845
		FN3	510..601	CDD:238020
		FN3	617..699	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910