Protein Alignment DIP-zeta and wrk-1

DIOPT Version :10

• Sequence 1: NP_723441.2
• Gene: DIP-zeta / 34231
• FlyBaseID: FBgn0051708
• Length: 532
• Species: Drosophila melanogaster
• Sequence 2: NP_001024651.1
• Gene: wrk-1 / 181093
• WormBaseID: WBGene00006942
• Length: 452
• Species: Caenorhabditis elegans
• Alignment Length: 488
• Identity: 91/488 - (18%)
• Similarity: 163/488 - (33%)
• Gaps: 108/488 - (22%)

  Fly    91 GVIVAGGGANVPTSNLNIVVEEPEFTEYIENVTVPAGRNVKLGCSVKNLGSYKVAWMHFEQSAIL 155
            |:::|...|.:.|....::.:|              |.::.|.|.|:: .|..:.|.  :.:.::
 Worm    10 GLLIASTSAQIRTKGGTLIAKE--------------GESLTLRCEVED-PSVAIIWR--KNTEVV 57

  Fly   156 TVHNHVITRNPRISVTHDKHDRHRTWYLHINNVHEEDRGRYMCQIN------TVTAKTQ-FGYLN 213
            .|.:.::.......::.:    ..|..|.|..|...:...|.|.:.      |...|.| |....
 Worm    58 AVDDEILDTYGGYEISME----GSTSVLTIKRVEPINSANYSCALAEPEVSVTFVIKVQVFKPTQ 118

  Fly   214 VVVPPNIDDSLSSSDVIVREG-ANISLRCRA-SGSPRPIIKWKRDDNSRIAINKNHIVNEWEGDT 276
            |.|.|.:..|..:.....|.| .|:.:.|.. .|:|:|.:.|.:    :.|.....|..|..|..
 Worm   119 VSVKPLVVISPDTGVYHARVGEKNLVITCHVKEGNPKPGVVWTK----QAAKLPEDIKREHGGAR 179

  Fly   277 LEITRISRLDMGAYLCIASNGVPPTVSKRIKVSVDFP--------PMLLIPHQLVGAPEGFNVTI 333
            :.||.:.:...|.|.|:|.| :..:....|.:.|..|        |.:......:...:..|.:.
 Worm   180 IVITEVKKHHAGKYNCLAEN-IAGSDRATIDIHVAEPLQGEREEKPWVKNEDTFIPVRKNQNASF 243

  Fly   334 ECFTEAHPTSLNYWTRGEGPIIHDSHKYK--VEATVGLPAYKTHMKLTIINVSSGDDGIYKCVAK 396
            .|..:..|.....|......|..:..|:|  .|....|..| :...||:.::|....|.|.|...
 Worm   244 WCTYDGTPVPQVEWLFNGYKINFNDEKFKKTSETAQRLNGY-SKSTLTVGDISEEAFGDYACRIS 307

  Fly   397 NPRGETDGIIRLYVSYPPTTASSGIYSTDTHWGENGINNNYAYGGPDSTRSIYAQDKNTRYQ--- 458
            |..|....::  :||..|.........::..|                  ::.|.||...||
 Worm   308 NKLGSVTAVV--HVSGRPGPPQLSFDESELTW------------------TVRAFDKILEYQLCH 352

  Fly   459 ----------SNLNEIGLSEQ--------------KSFLD---------KTQNPLLANGNANEA- 489
                      .:.|.:.:.:.              .:||:         |.:|.|.....|.:|
 Worm   353 RLENADHFLPEDCNSVRVKKSDNNGDDKWTHTIDLSTFLEHGNKYHVQLKARNALGWGSMAKDAL 417

  Fly   490 -----DAESNGARGHNPSMAIAWLFVVIATLLL 517
                 ..|...|:|.:....|:.:.|.:.|:.|
 Worm   418 HVELQRIEKEEAKGASIISIISSILVTLVTMYL 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	18/102 (18%)
		Ig strand B	130..134	CDD:409405	1/3 (33%)
		Ig strand C	143..147	CDD:409405	0/3 (0%)
		Ig strand E	178..185	CDD:409405	2/6 (33%)
		IgI_1_MuSK	218..310	CDD:409562	22/93 (24%)
		Ig strand A	218..221	CDD:409562	1/2 (50%)
		Ig strand A'	226..231	CDD:409562	0/4 (0%)
		Ig strand B	237..244	CDD:409562	1/7 (14%)
		Ig strand C	250..255	CDD:409562	1/4 (25%)
		Ig strand C'	257..259	CDD:409562	0/1 (0%)
		Ig strand D	267..270	CDD:409562	1/2 (50%)
		Ig strand E	275..281	CDD:409562	1/5 (20%)
		Ig strand F	288..295	CDD:409562	3/6 (50%)
		Ig strand G	302..310	CDD:409562	1/7 (14%)
		IG_like	325..410	CDD:214653	18/86 (21%)
		Ig strand B	331..335	CDD:143207	0/3 (0%)
		Ig strand C	344..348	CDD:143207	0/3 (0%)
		Ig strand E	376..380	CDD:143207	1/3 (33%)
		Ig strand F	390..395	CDD:143207	2/4 (50%)
		Ig strand G	403..406	CDD:143207	0/2 (0%)
wrk-1	NP_001024651.1	IG_like	25..113	CDD:214653	16/108 (15%)
		Ig strand B	35..39	CDD:409353	1/3 (33%)
		Ig strand C	47..51	CDD:409353	0/3 (0%)
		Ig strand E	77..83	CDD:409353	2/5 (40%)
		Ig strand F	93..98	CDD:409353	2/4 (50%)
		Ig strand G	104..107	CDD:409353	0/2 (0%)
		Ig	136..212	CDD:472250	20/80 (25%)
		Ig strand B	143..147	CDD:409353	0/3 (0%)
		Ig strand C	157..161	CDD:409353	0/3 (0%)
		Ig strand E	178..182	CDD:409353	0/3 (0%)
		Ig strand F	192..197	CDD:409353	2/4 (50%)
		Ig	235..319	CDD:472250	18/86 (21%)
		Ig strand C	254..258	CDD:409353	0/3 (0%)
		Ig strand E	278..291	CDD:409353	3/13 (23%)
		Ig strand F	301..306	CDD:409353	2/4 (50%)
		Ig strand G	314..317	CDD:409353	0/2 (0%)