Protein Alignment CG9541 and AK9

DIOPT Version :10

• Sequence 1: NP_001260273.1
• Gene: CG9541 / 34220
• FlyBaseID: FBgn0032083
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: XP_011533852.1
• Gene: AK9 / 221264
• HGNCID: 33814
• Length: 1988
• Species: Homo sapiens
• Alignment Length: 642
• Identity: 117/642 - (18%)
• Similarity: 206/642 - (32%)
• Gaps: 255/642 - (39%)

  Fly    64 DPPKVPV--IFVLGGPGSGKVTHCDTFMQERRGVTHINMMDLLQQYAM-------GNDMQDFS-- 117
            :|.|.|.  |.::|..|||| |.|...:.|:..:.||...::||:..:       |.:.::.|
Human  1057 EPLKAPPLRICLVGPQGSGK-TMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEKKVGPEFEEDSEN 1120

  Fly   118 -------------------------------QLSSK----------------TVTEVLMLE--MK 133
                                           ||:.:                .:.||::.|  :|
Human  1121 EQAAKQELEELAIQANVKVEEENTKKQLPEVQLTEEEEVIKSSLMENEPLPPEILEVILSEWWLK 1185

  Fly   134 MAPAAKAYLISGYPRSMRDVVEYSEKIQVV-------NGVILI-----------------SW--- 171
            ....:..:::.|:||       |.|:.|.:       :..:.|                 .|
Human  1186 EPIRSTGFILDGFPR-------YPEEAQFLGDRGFFPDAAVFIQVDDQDIFDRLLPAQIEKWKLK 1243

  Fly   172 -RQSVLQKQI--DYGAKL---------GHVVLSLAKM----------------------ELENFF 202
             ::.:.:|::  |..||:         ..::|...|.                      ::||..
Human  1244 QKKKLERKKLIKDMKAKIRVDTIAKRRAELILERDKKRRENVVRDDEEISEEELEEDNDDIENIL 1308

  Fly   203 KNVMP--------VADYFDQSDMLLAVNGE-----RAPTE----VYKDFRTAVLDILS------- 243
            ::..|        ..|...::|.:..:.||     .|.|.    :..:....::.|:|
Human  1309 EDEFPKDEEEMSGEEDEEQETDAIERLRGELGEKFEADTHNLQIIQDELERYLIPIISINGARRN 1373

  Fly   244 -------------TLENQEAVMNGVTGMGRGIHDIPGSIVSVDTA-------------PSQAQQG 282
                         .:||:.::.       ...|.||..:......             |.:..:|
Human  1374 HIVQYTLNMKLKPLVENRASIF-------EKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEG 1431

  Fly   283 TQIAEDNDVTNASETAGTVLARDLAI--------ERMDGGPNGAVTALKTGTTSADDDSGVVVTQ 339
            ..|   ..|.||......|:.|....        |:....|                   :...:
Human  1432 ETI---KPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP-------------------IKYIR 1474

  Fly   340 QPKLRQAAGPDESGSDLPPIIWVIGGPGSNKAT-LCL---KAVGLNPGWAHISVGRLLRNITDSA 400
            |||.:..         :|..|.::|.|.|.|.| ||.   |.:....|..|:|:|..||.:.::.
Human  1475 QPKPKPT---------VPIRIIIVGPPKSGKTTVLCFSVAKKITSEYGLKHLSIGGALRYVLNNH 1530

  Fly   401 PRANTE-SFAVKEALAAGDMAPEKSLNQLLETNLRQ-LRDRTGIIVDGYPRNLQQVKYFENKYKQ 463
            |  .|| :..:...|..|..||::...|.||.:|.: :.:..|:::||||....|:...|  .:.
Human  1531 P--ETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNTAGVVIDGYPVTKHQMNLLE--ARS 1591

  Fly   464 RPPIILLDCSKLQLGRGRIDDTVSS---FRR-RLELFREQTLPMLKILDTSNRLQIV 516
            ..|:::.:.|            |.|   |:| .||...||.||    ....|..|||
Human  1592 IIPMVIFELS------------VPSKEIFKRLLLEKENEQRLP----YPLHNSAQIV 1632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9541	NP_001260273.1	ADK	70..230	CDD:238713	44/297 (15%)
		aden_kin_iso1	358..521	CDD:130427	49/169 (29%)
AK9	XP_011533852.1	NK	105..348	CDD:450170
		YHS	1002..1057	CDD:442578	117/642 (18%)
		ADK	1065..>1233	CDD:238713	28/175 (16%)
		NK	1485..>1612	CDD:450170	39/142 (27%)