DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9541 and AK9

DIOPT Version :9

Sequence 1:	NP_001260273.1	Gene:	CG9541 / 34220	FlyBaseID:	FBgn0032083	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	XP_011533852.1	Gene:	AK9 / 221264	HGNCID:	33814	Length:	1988	Species:	Homo sapiens

Alignment Length:	642	Identity:	117/642 - (18%)
Similarity:	206/642 - (32%)	Gaps:	255/642 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 DPPKVPV--IFVLGGPGSGKVTHCDTFMQERRGVTHINMMDLLQQYAM-------GNDMQDFS-- 117
            :|.|.|.  |.::|..|||| |.|...:.|:..:.||...::||:..:       |.:.::.|
Human  1057 EPLKAPPLRICLVGPQGSGK-TMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEKKVGPEFEEDSEN 1120

  Fly   118 -------------------------------QLSSK----------------TVTEVLMLE--MK 133
                                           ||:.:                .:.||::.|  :|
Human  1121 EQAAKQELEELAIQANVKVEEENTKKQLPEVQLTEEEEVIKSSLMENEPLPPEILEVILSEWWLK 1185

  Fly   134 MAPAAKAYLISGYPRSMRDVVEYSEKIQVV-------NGVILI-----------------SW--- 171
            ....:..:::.|:||       |.|:.|.:       :..:.|                 .|
Human  1186 EPIRSTGFILDGFPR-------YPEEAQFLGDRGFFPDAAVFIQVDDQDIFDRLLPAQIEKWKLK 1243

  Fly   172 -RQSVLQKQI--DYGAKL---------GHVVLSLAKM----------------------ELENFF 202
             ::.:.:|::  |..||:         ..::|...|.                      ::||..
Human  1244 QKKKLERKKLIKDMKAKIRVDTIAKRRAELILERDKKRRENVVRDDEEISEEELEEDNDDIENIL 1308

  Fly   203 KNVMP--------VADYFDQSDMLLAVNGE-----RAPTE----VYKDFRTAVLDILS------- 243
            ::..|        ..|...::|.:..:.||     .|.|.    :..:....::.|:|
Human  1309 EDEFPKDEEEMSGEEDEEQETDAIERLRGELGEKFEADTHNLQIIQDELERYLIPIISINGARRN 1373

  Fly   244 -------------TLENQEAVMNGVTGMGRGIHDIPGSIVSVDTA-------------PSQAQQG 282
                         .:||:.::.       ...|.||..:......             |.:..:|
Human  1374 HIVQYTLNMKLKPLVENRASIF-------EKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEG 1431

  Fly   283 TQIAEDNDVTNASETAGTVLARDLAI--------ERMDGGPNGAVTALKTGTTSADDDSGVVVTQ 339
            ..|   ..|.||......|:.|....        |:....|                   :...:
Human  1432 ETI---KPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP-------------------IKYIR 1474

  Fly   340 QPKLRQAAGPDESGSDLPPIIWVIGGPGSNKAT-LCL---KAVGLNPGWAHISVGRLLRNITDSA 400
            |||.:..         :|..|.::|.|.|.|.| ||.   |.:....|..|:|:|..||.:.::.
Human  1475 QPKPKPT---------VPIRIIIVGPPKSGKTTVLCFSVAKKITSEYGLKHLSIGGALRYVLNNH 1530

  Fly   401 PRANTE-SFAVKEALAAGDMAPEKSLNQLLETNLRQ-LRDRTGIIVDGYPRNLQQVKYFENKYKQ 463
            |  .|| :..:...|..|..||::...|.||.:|.: :.:..|:::||||....|:...|  .:.
Human  1531 P--ETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNTAGVVIDGYPVTKHQMNLLE--ARS 1591

  Fly   464 RPPIILLDCSKLQLGRGRIDDTVSS---FRR-RLELFREQTLPMLKILDTSNRLQIV 516
            ..|:::.:.|            |.|   |:| .||...||.||    ....|..|||
Human  1592 IIPMVIFELS------------VPSKEIFKRLLLEKENEQRLP----YPLHNSAQIV 1632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9541	NP_001260273.1	aden_kin_iso1	67..238	CDD:130427	46/308 (15%)
		ADK	70..230	CDD:238713	44/297 (15%)
		aden_kin_iso1	358..521	CDD:130427	49/169 (29%)
		ADK	359..521	CDD:238713	49/168 (29%)
AK9	XP_011533852.1	ADK	105..348	CDD:238713
		Ribosomal_L24e_L24	1017..1059	CDD:321242	0/1 (0%)
		ADK	1065..>1233	CDD:238713	28/175 (16%)
		ADK	1485..>1612	CDD:238713	39/142 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148401
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0563
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830