Protein Alignment LManVI and Man2b2

DIOPT Version :10

• Sequence 1: NP_609253.1
• Gene: LManVI / 34206
• FlyBaseID: FBgn0032069
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: NP_001128443.2
• Gene: Man2b2 / 360955
• RGDID: 1308840
• Length: 1004
• Species: Rattus norvegicus
• Alignment Length: 1147
• Identity: 309/1147 - (26%)
• Similarity: 478/1147 - (41%)
• Gaps: 296/1147 - (25%)

  Fly     6 GIVLFVALLA-------ISVRPSEEACGYEACPKTKTNMINIHMVPHSHDDVGWLKTVDQYFYGH 63
            |::.::.||.       ::.||        |.|      |...:|||||.||||:.||.:....:
  Rat     2 GLLRWLPLLGQLLLLWPLAARP--------ASP------IRAFVVPHSHMDVGWVYTVQESMRAY 52

  Fly    64 RSNIQHAGVQYIIDTVIAELIKDPARRFIQVETSFFAKWW-AEQSETAKQVVRKLVNEGRLEFTG 127
            .:|        :..||:.||::...||||.||..||..|| ...||..||.||:|::||||||..
  Rat    53 AAN--------VYTTVVEELVRGRQRRFIAVEQEFFRLWWDGVASEQQKQQVRQLLDEGRLEFVL 109

  Fly   128 GAWSMNDEAAVNYQSVIDQFTLGLKFLDDTFGSCARPRIGWQIDPFGHSREQASIFAQMGYDGEF 192
            |...|:|||..:....|.|.|.|..||.:|||  .||:..|.:||||.|....::||..|::...
  Rat   110 GGQVMHDEAVTHLDDQILQLTEGHGFLYETFG--IRPQFSWHVDPFGASATTPTLFALAGFNAHL 172

  Fly   193 FARMDHRDKNDRIDNLGMEMIWDASDSLS-NDEIFTGL--LYRHYSAPPGYCFDVHCG------- 247
            .:|:|:..|:...:..|::.:|..|.||| ..||:|.:  || .|..|....|....|
  Rat   173 ISRIDYDLKDAMQEAQGLQFVWHGSPSLSEQQEIYTHVMDLY-SYCTPSHIPFSNRSGFYWNGVA 236

  Fly   248 --------------DDPIIDTKSYDN----------NVKSRVDDFLSYVTSVAQHYRSNHIMIPM 288
                          .:|:    :.||          |||.|           |..:|:.|::.|.
  Rat   237 VFPEPPPDGVYPNMSEPV----TVDNIHLYAEALVANVKQR-----------AAWFRTPHVLWPW 286

  Fly   289 GDDFQYEDAQVNFKNMDKLIKYVNERQAEGSTFNLFYSTPACYLNSLHEGLQTWPNKT-QDFFPY 352
            |.|.|:.:|.|.|.|||.|::|:|.|.|:.. .::.|:|...|..:||:...||..:. .||.||
  Rat   287 GCDKQFFNASVQFDNMDPLLEYINNRSAQFG-ISVQYATLNDYFQALHDFNVTWDIRDHHDFLPY 350

  Fly   353 GSDDNSYWTGYFTSRPTQKRFERDGNHILQVAKQLSVFAE---------LNTKQQKEDLEYLREI 408
            .|:....|||:||||.|.|...|..:.:|...:  |:|..         |:.....:.|:.||..
  Rat   351 SSEPQQAWTGFFTSRSTLKGLARQASALLYAGE--SMFTRYMWPHPRGTLDPTWALQQLQQLRWA 413

  Fly   409 MGVMQHHDAITGTEKQHVSDDYDRILYDAILGGVNTARDGLRKL-----TNLPNGEFESCLQLNI 468
            :..:||||||||||...|.:.|        :..::....|:.||     .:.|.|.......:..
  Rat   414 VSEVQHHDAITGTESPKVKNMY--------MEHLSMGMRGVHKLMASIALDRPPGSGTDTRPVGY 470

  Fly   469 SECAFTKDDADNVVVTLYNPLAHTSTQYVRVPVKNENYEVTDEKGRVVASEVVPVAWQVLALEFR 533
            |             .::|||||...|..:.:.|...:..||||.||.|::::
  Rat   471 S-------------ASVYNPLAWKITTIITLTVAFPSVSVTDELGRPVSAQI------------- 509

  Fly   534 NNDTQ----HELVFKASVDKIA--NYYIKKVASQETKNVAAHTKSKRSIKAEEANLEVPKRFKKV 592
            .|.|:    ::|:...::..::  :|.:::     |:...|.|   |.:....||     ..|..
  Rat   510 QNSTKDPSAYDLLILTTIPGLSYRHYKVRR-----TRGDQAGT---RELVTPRAN-----TLKFS 561

  Fly   593 HSLKNATETFDDDEGETVVQTSQ--VKLVIDNKTGLLKTVE--MNGVSENIDQSYGVYRTYD--- 650
            ..|:|.|    ..||:.:|....  ..|:.|..|.:|.:::  .:..:.::.|.:..||...
  Rat   562 RKLRNQT----SQEGKLLVPVMNDCYTLLFDQDTNMLHSIQDRQSNRTVHMTQEFLEYRANGDVK 622

  Fly   651 ----SGAYVFRQYHQADFIVQYEGVEFTVYDGALVKEVHQQFSEYISQVIRIYE----------- 700
                |..|:|.....|:...:..|:|..|  |.|..:|.|.|...|:....||.
  Rat   623 QGPISDNYLFASNDTAEPSWEAVGMEMVV--GTLATDVRQYFYRNITDQGYIYSIHTRLAHVHPS 685

  Fly   701 --GKNL---VEIEWQVGPIEREEEFGREVVIIFNSTIASDGVSYTDSNGREMIKRVKDQRETFTP 760
              |:.|   :|.::||||:    :..||.::..:|.:.|..|.|:|:||.:|      ||..: .
  Rat   686 LAGELLCRRIEQQYQVGPL----DLNREAILRTSSDLNSQQVLYSDNNGYQM------QRRPY-K 739

  Fly   761 GLDRQPTAANYYPVTSRIALQDSKKRIAVLNDRAQGGASMLNGQLELMLHRR----LVRDDGYGV 821
            .....|...||||:.....::|.|.|:.:|.:|..|.:|..|||:|:|||||    ||.|..|.:
  Rat   740 AFKSNPIPRNYYPMVQSAFIEDDKSRLVLLAERPHGVSSQENGQVEVMLHRRLWNNLVWDLNYNL 804

  Fly   822 GEALNEEKYGQPMIARGKVYLILSPSDESTAAE-------------------REAEKEIH----- 862
              .||:.....|::     :|:|.|...:||..                   .|.|..||
  Rat   805 --TLNDTSVVHPVL-----WLLLGPKSTTTALRPRSGVALQHRPVVLLKELTDEEETAIHRPHHP 862

  Fly   863 ---------------LPFWKFFSKNTGSTTAAAKSVPSFNDFPKSVHLLTLE-------PFNDDE 905
                           ||.|: :|:|                  .:.||..|:       ..|...
  Rat   863 WPVTLPPSLHLQVLSLPGWQ-YSRN------------------HAQHLKNLQRGHPEKPQVNLQR 908

  Fly   906 VLLRVENFLDHTEGQVVSFNIRP----IFDYLNG----VEIRETTLDGNLPLSDMKRFKFHHDSS 962
            ||||:.:..:..|..|:|   ||    :...|.|    |.:.|.:|.|...:..::|:.: ....
  Rat   909 VLLRLHHLYEAGEDPVLS---RPATVDLKIALRGLGSVVAVEERSLTGTWDVQTLQRWHW-RTKI 969

  Fly   963 GQKPDAVEYFTSAHKPLAAEQSQEASEFSVTLHPMQIRTFII 1004
            ||        ...| |.:..:|...|  .:|::|.:||||.|
  Rat   970 GQ--------LKGH-PTSPPRSPGGS--IITVYPKEIRTFFI 1000

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManVI	NP_609253.1	GH38N_AMII_LAM_like	38..312	CDD:212121	105/308 (34%)
		PLN02701	40..898	CDD:178304	270/983 (27%)
Man2b2	NP_001128443.2	PLN02701	27..792	CDD:178304	247/857 (29%)
		GH38N_AMII_Epman_like	27..352	CDD:212122	119/351 (34%)