Protein Alignment LManVI and Man2a1

DIOPT Version :10

• Sequence 1: NP_609253.1
• Gene: LManVI / 34206
• FlyBaseID: FBgn0032069
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: NP_037111.2
• Gene: Man2a1 / 25478
• RGDID: 3038
• Length: 1148
• Species: Rattus norvegicus
• Alignment Length: 1103
• Identity: 270/1103 - (24%)
• Similarity: 460/1103 - (41%)
• Gaps: 256/1103 - (23%)

  Fly    38 INIHMVPHSHDDVGWLKTVDQYFYGHRSNIQHAGVQYIIDTVIAELIKDPARRFIQVETSFFAKW 102
            :.:.:|||||:|.|||||.:.||        ....|||.:.::.:|.:|.:|:||..|.|:.|||
  Rat   165 LQVFVVPHSHNDPGWLKTFNDYF--------RDKTQYIFNNMVLKLKEDSSRKFIWSEISYLAKW 221

  Fly   103 WAEQSETAKQVVRKLVNEGRLEFTGGAWSMNDEAAVNYQSVIDQFTLGLKFLDDTFGSCARPRIG 167
            |.......|:.|:.|:..|:||...|.|.|.|||..:|.::|||...|.::|:...|  .:||.|
  Rat   222 WDIIDNPKKEAVKSLLQNGQLEIVTGGWVMADEATTHYFALIDQLIEGHQWLEKNLG--VKPRSG 284

  Fly   168 WQIDPFGHSREQASIFAQMGYDGEFFARMDHRDKNDRIDNLGMEMIWDAS-DSLSNDEIFTGLLY 231
            |.|||||||.....:..:.|:......|:.:..|........:|..|..: |..|..:|...::
  Rat   285 WAIDPFGHSPTMTYLLKRAGFSHMLIQRVHYSVKKHFSLQKTLEFFWRQNWDLGSTTDILCHMM- 348

  Fly   232 RHYSAPPGYCFDV-H-CGDDPII----DTKSY-----------------DNNVKSRVDDFLSYVT 273
                  |.|.:|: | ||.||.|    |.|..                 ..||:||....|....
  Rat   349 ------PFYSYDIPHTCGPDPKICCQFDFKRLPGGRYGCPWGVPPEAISPGNVQSRAQMLLDQYR 407

  Fly   274 SVAQHYRSNHIMIPMGDDF---QYEDAQVNFKNMDKLIKYVNERQAEGSTFNLFYSTPACYLNSL 335
            ..::.:|:..::.|:||||   :|.:..:.::|.::|..|:|.:  ......:.:.|.:.|.::|
  Rat   408 KKSKLFRTKVLLAPLGDDFRFSEYTEWDLQYRNYEQLFSYMNSQ--PHLKVKIQFGTLSDYFDAL 470

  Fly   336 HE--------GLQTWPNKTQDFFPYGSDDNSYWTGYFTSRPTQKRFERDGNHILQVAKQLSVFAE 392
            .:        |...:|..:.|||.|...|:.||:|||||||..||.:|.....|:.|:   :...
  Rat   471 EKSVAAEKKGGQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRLRTAE---ILYH 532

  Fly   393 LNTKQQKE-------------DLEYLREIMGVMQHHDAITGTEKQHVSDDYDRILY------DAI 438
            |..||.::             .|...|..:|:.|||||||||.|..|..||...|:      :.|
  Rat   533 LALKQAQKYKINKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSLNSLEKI 597

  Fly   439 LGG--------------------------VNTARDGLRKLTNLPNGEFESCLQLNISECAFTKDD 477
            :|.                          ..:::|.|.|         ::.:||:..|..:
  Rat   598 IGDSAFLLILKDKKLYQSDPSKAFLEMDTKQSSQDSLPK---------KNIIQLSAQEPRY---- 649

  Fly   478 ADNVVVTLYNPLAHTSTQYVRVPVKNENYEVTDEKGRVVASEVVPVAWQVLALEFRNNDTQHELV 542
                 :.:|||........|.|.|.:...:|..:.|:.|..:|..| |:.:.   ..:...:|:.
  Rat   650 -----LVVYNPFEQERHSVVSVRVNSATVKVLSDLGKAVEVQVSAV-WKDMR---TTSQAAYEVA 705

  Fly   543 FKASVDKIANYYIKKVASQ-ETKNVAAHTKSKRSIKAEEANLEVPKRFKKVHSLKNATETFDDDE 606
            |.|.:..:.....|.:.|| .:.::|.:.......:||..          :..:||..     |.
  Rat   706 FLAHLPPLGLKVYKILESQSSSSHLADYFLYNNDGQAESG----------IFHMKNMV-----DS 755

  Fly   607 GETV-VQTSQVKLVIDNKTGLLKTVEMNGVSENIDQS-------YGVYRTYD-SGAYVFRQYHQA 662
            |:.: ::.|.:.|..| ::||::.|...  .:|..|.       ||.....| ||||:|....|.
  Rat   756 GDAITIENSFLTLGFD-RSGLMEKVRRK--EDNKQQELKVQFLWYGTTNKRDKSGAYLFLPDGQG 817

  Fly   663 DFIVQYEGVEFTVYDGALVKEVHQQFSEYISQVIRIY-----EGK-----NLVEIEWQVGPIERE 717
            ...|........|..|.:..:| ..|.|:::..:|:|     ||:     |:|:|         .
  Rat   818 QPYVSLRTPFVRVTRGRIYSDV-TCFLEHVTHKVRLYHIQGIEGQSMEVSNIVDI---------R 872

  Fly   718 EEFGREVVIIFNSTIASDGVSYTDSNGREMIKRVKDQRETFTPGLDRQPTAANYYPVTSRIALQD 782
            ....||:|:..:|.|.:....|||.||.::     ..|.|    :.:.|..||.||:::...:||
  Rat   873 SVHNREIVMRISSKINNQNRYYTDLNGYQI-----QPRRT----MAKLPLQANVYPMSTMAYIQD 928

  Fly   783 SKKRIAVLNDRAQGGASMLNGQLELMLHRRLVRDDGYGVGEALNEEKYGQPMIARGKVYLILSPS 847
            :..|:.:|:.::.|.:||.:||:|:.:.|||::||..|:|:.:::.|      ....::.||  .
  Rat   929 AAHRLTLLSAQSLGASSMASGQIEVFMDRRLMQDDNRGLGQGVHDNK------ITANLFRIL--L 985

  Fly   848 DESTAAEREAEKEIHLPFWKFFSKNTGS---------------TTAAAKSVPSF----NDFPKSV 893
            ::......|.:|:..:.:....|..|.:               .:.|.:.:..|    :..|..:
  Rat   986 EKRNGMNMEEDKKSPVSYPSLLSHMTSAFLNHPFLPMVLSGQLPSPAIELLSEFRLLQSSLPCDI 1050

  Fly   894 HLLTL--------EPFNDDEVLLRVENFLDHTEGQVVSFNIRPIFD---YLNGVEIRETTLDGNL 947
            ||:.|        :.::|:..|:.      |          |.:||   ....:.:..:|..|.:
  Rat  1051 HLVNLRTIQSKVGKGYSDEAALIL------H----------RKVFDCQLSSRAMGLPCSTTQGKM 1099

  Fly   948 PLSDMKRFKFHHDSSGQKPDAVEYFTSA-----HKPLAAEQSQEASEFSVTLHPMQIRTFIIK 1005
            .:..:    |::       .|||.|..:     |.|..|:.:.|     |:|.||:|.|..|:
  Rat  1100 SIPKL----FNN-------FAVESFIPSSLSLMHSPPDAQNTSE-----VSLSPMEISTSRIR 1146

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManVI	NP_609253.1	GH38N_AMII_LAM_like	38..312	CDD:212121	91/300 (30%)
		PLN02701	40..898	CDD:178304	245/976 (25%)
Man2a1	NP_037111.2	PLN02701	127..1148	CDD:178304	270/1103 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1121..1148		11/31 (35%)