Protein Alignment LManVI and Man2a1

DIOPT Version :10

• Sequence 1: NP_609253.1
• Gene: LManVI / 34206
• FlyBaseID: FBgn0032069
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: NP_032575.2
• Gene: Man2a1 / 17158
• MGIID: 104669
• Length: 1150
• Species: Mus musculus
• Alignment Length: 1089
• Identity: 271/1089 - (24%)
• Similarity: 457/1089 - (41%)
• Gaps: 228/1089 - (20%)

  Fly    38 INIHMVPHSHDDVGWLKTVDQYFYGHRSNIQHAGVQYIIDTVIAELIKDPARRFIQVETSFFAKW 102
            :.:.:|||||:|.|||||.:.||        ....|||.:.::.:|.:|.:|:|:..|.|:.|||
Mouse   165 LQVFVVPHSHNDPGWLKTFNDYF--------RDKTQYIFNNMVLKLKEDSSRKFMWSEISYLAKW 221

  Fly   103 WAEQSETAKQVVRKLVNEGRLEFTGGAWSMNDEAAVNYQSVIDQFTLGLKFLDDTFGSCARPRIG 167
            |.......|:.|:.|:..|:||...|.|.|.|||..:|.::|||...|.::|:...|  .:||.|
Mouse   222 WDIIDIPKKEAVKSLLQNGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLEKNLG--VKPRSG 284

  Fly   168 WQIDPFGHSREQASIFAQMGYDGEFFARMDHRDKNDRIDNLGMEMIWDAS-DSLSNDEIFTGLLY 231
            |.|||||||...|.:..:.|:......|:.:..|.....:..:|..|..: |..|..:|...::
Mouse   285 WAIDPFGHSPTMAYLLKRAGFSHMLIQRVHYAIKKHFSLHKTLEFFWRQNWDLGSATDILCHMM- 348

  Fly   232 RHYSAPPGYCFDV-H-CGDDPII----DTKSY-----------------DNNVKSRVDDFLSYVT 273
                  |.|.:|: | ||.||.|    |.|..                 ..||:||....|....
Mouse   349 ------PFYSYDIPHTCGPDPKICCQFDFKRLPGGRYGCPWGVPPEAISPGNVQSRAQMLLDQYR 407

  Fly   274 SVAQHYRSNHIMIPMGDDF---QYEDAQVNFKNMDKLIKYVNERQAEGSTFNLFYSTPACYLNSL 335
            ..::.:|:..::.|:||||   :|.:..:..:|.::|..|:|.:  ......:.:.|.:.|.::|
Mouse   408 KKSKLFRTKVLLAPLGDDFRFSEYTEWDLQCRNYEQLFSYMNSQ--PHLKVKIQFGTLSDYFDAL 470

  Fly   336 HEGL--------QTWPNKTQDFFPYGSDDNSYWTGYFTSRPTQKRFERDGNHILQVAKQLSVFAE 392
            .:.:        ..:|..:.|||.|...|:.||:|||||||..||.:|.....::.|:   :..:
Mouse   471 EKAVAAEKKSSQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRIRAAE---ILYQ 532

  Fly   393 LNTKQQKE-------------DLEYLREIMGVMQHHDAITGTEKQHVSDDYDRILYDAILGGVNT 444
            |..||.::             .|...|..:|:.|||||||||.|..|..||...|:.::
Mouse   533 LALKQAQKYKINKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSL------ 591

  Fly   445 ARDGLRKLTNLPNGEFESCLQLNISE---------CAFTKDDA---------DNVVVTL------ 485
              :.|.|:..      :|...|.:.:         .||.:.|.         ..:::.|
Mouse   592 --NSLEKIIG------DSAFLLILKDKKLYQSDPSKAFLEMDTKQSSQDSLPQKIIIQLSAQEPR 648

  Fly   486 ----YNPLAHTSTQYVRVPVKNENYEVTDEKGRVVASEVVPVAWQVLALEFRN-NDTQHELVFKA 545
                |||........|.:.|.:...:|..:.|:.|..:|..| |.    :.|. :...:|:.|.|
Mouse   649 YLVVYNPFEQERHSVVSIRVNSATVKVLSDSGKPVEVQVSAV-WN----DMRTISQAAYEVSFLA 708

  Fly   546 SVDKIANYYIKKVASQ-ETKNVAAHTKSKRSIKAEEANLEVPKRFKKVHSLKNATETFDDDEGET 609
            .:..:.....|.:.|| .:.::|.:........||..          :..:||..     |.|:.
Mouse   709 HIPPLGLKVFKILESQSSSSHLADYVLYNNDGLAENG----------IFHVKNMV-----DAGDA 758

  Fly   610 VVQTSQVKLVIDNKTGLLKTVEMNGVSENIDQS-----YGVYRTYD-SGAYVFRQYHQADFIVQY 668
            :...:....:..:::||::.|.....|...:..     ||.....| ||||:|....|....|..
Mouse   759 ITIENPFLAIWFDRSGLMEKVRRKEDSRQHELKVQFLWYGTTNKRDKSGAYLFLPDGQGQPYVSL 823

  Fly   669 EGVEFTVYDGALVKEVHQQFSEYISQVIRIYEGKNLVEIEWQVGPIER----EEEFGREVVIIFN 729
            ......|..|.:..:| ..|.|:::..:|:|   |:..||.|...:..    .....||:|:..:
Mouse   824 RPPFVRVTRGRIYSDV-TCFLEHVTHKVRLY---NIQGIEGQSMEVSNIVNIRNVHNREIVMRIS 884

  Fly   730 STIASDGVSYTDSNGREMIKRVKDQRETFTPGLDRQPTAANYYPVTSRIALQDSKKRIAVLNDRA 794
            |.|.:....|||.||.::     ..|.|    :.:.|..||.||:.:...:||::.|:.:|:.::
Mouse   885 SKINNQNRYYTDLNGYQI-----QPRRT----MSKLPLQANVYPMCTMAYIQDAEHRLTLLSAQS 940

  Fly   795 QGGASMLNGQLELMLHRRLVRDDGYGVGEALNEEKYGQPMIARGKVYLILSPSDESTAAEREAEK 859
            .|.:||.:||:|:.:.|||::||..|:|:.:::.|      ....::.||  .::.:|...|.||
Mouse   941 LGASSMASGQIEVFMDRRLMQDDNRGLGQGVHDNK------ITANLFRIL--LEKRSAVNMEEEK 997

  Fly   860 EIHLPFWKFFSKNTGS---------TTAAAKSVPSF----------NDFPKSVHLLTL------- 898
            :..:.:....|..|.|         ..:.....|:|          :..|..:||:.|
Mouse   998 KSPVSYPSLLSHMTSSFLNHPFLPMVLSGQLPSPAFELLSEFPLLQSSLPCDIHLVNLRTIQSKM 1062

  Fly   899 -EPFNDDEVLLRVENFLDHTEGQVVSFNIRPIFDYLNGVEIRETTLDGNLPLSDMKRF-KFHHDS 961
             :.::|:..|:.      |.:|....|:.|       |:.:..:|..|.  :|.:|.| ||
Mouse  1063 GKGYSDEAALIL------HRKGFDCQFSSR-------GIGLPCSTTQGK--MSVLKLFNKF---- 1108

  Fly   962 SGQKPDAVEYFTSA-----HKPLAAEQSQEASEFSVTLHPMQIRTFIIK 1005
                  |||....:     |.|..|:...|     |:|.||:|.||.|:
Mouse  1109 ------AVESLVPSSLSLMHSPPDAQNMSE-----VSLSPMEISTFRIR 1146

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManVI	NP_609253.1	GH38N_AMII_LAM_like	38..312	CDD:212121	91/300 (30%)
		PLN02701	40..898	CDD:178304	241/964 (25%)
Man2a1	NP_032575.2	PLN02701	127..1148	CDD:178304	271/1089 (25%)