DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManVI and Man2a2

DIOPT Version :9

Sequence 1:	NP_609253.1	Gene:	LManVI / 34206	FlyBaseID:	FBgn0032069	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_766491.2	Gene:	Man2a2 / 140481	MGIID:	2150656	Length:	1152	Species:	Mus musculus

Alignment Length:	1125	Identity:	299/1125 - (26%)
Similarity:	471/1125 - (41%)	Gaps:	291/1125 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 TNMINIHMVPHSHDDVGWLKTVDQYFYGHRSNIQHAGVQYIIDTVIAELIKDPARRFIQVETSFF 99
            |..:.:.:|||||:|.||:||.|:|:...        .|:|:::::::|.:||.|||:..|.|||
Mouse   163 TEDLQVFVVPHSHNDPGWIKTFDKYYTEQ--------TQHILNSMVSKLQEDPRRRFLWAEVSFF 219

  Fly   100 AKWWAEQSETAKQVVRKLVNEGRLEFTGGAWSMNDEAAVNYQSVIDQFTLGLKFLDDTFGSCARP 164
            ||||...|...:..||:||..|:||...|.|.|.|||..:|.:::||...|.::|:...|  |.|
Mouse   220 AKWWDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLERNLG--ATP 282

  Fly   165 RIGWQIDPFGHSREQASIFAQMGYDGEFFARMDHRDKNDRIDNLGMEMIW-DASDSLSNDEIFTG 228
            |.||.:||||||.....:..:.........|:.:..|........:|.:| ...||.|:.:||..
Mouse   283 RSGWAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQMWDSDSSTDIFCH 347

  Fly   229 LLYRHYSAPPGYCFDV-H-CGDDPII----DTKSY-----------------DNNVKSRVDDFLS 270
            ::       |.|.:|| | ||.||.|    |.|..                 :.||..|....|.
Mouse   348 MM-------PFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVADRAALLLD 405

  Fly   271 YVTSVAQHYRSNHIMIPMGDDFQYE-----DAQVNFKNMDKLIKYVNER-----QAEGSTFNLFY 325
            .....::.:|||.:::|:||||:|:     |||  |.|..:|..::|.:     ||:       :
Mouse   406 QYRKKSRLFRSNVLLVPLGDDFRYDKPQEWDAQ--FFNYQRLFDFLNSKPEFHVQAQ-------F 461

  Fly   326 STPACYLNSLHE--GLQT------WPNKTQDFFPYGSDDNSYWTGYFTSRPTQKRFER------D 376
            .|.:.|.::|::  |::.      :|..:.|||.|...::.|||||:||||..|..:|      .
Mouse   462 GTLSEYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLR 526

  Fly   377 GNHILQ-----------VAKQ--LSVFAELNTKQQKEDLEYLREIMGVMQHHDAITGTEKQHVSD 428
            |..||.           :|.|  ||.||.|..         .|..:|:.|||||||||.|:.|..
Mouse   527 GAEILYSLALAHARRSGLAGQYPLSDFALLTE---------ARRTLGLFQHHDAITGTAKEAVVV 582

  Fly   429 DYDRILYDAILGGVNTARDGLRKLTNLPN-----------GEFES--------CLQLN------- 467
            ||          ||..    ||.|.:|..           |:.|:        .||::
Mouse   583 DY----------GVRL----LRSLVSLKQVIINAAHYLVLGDQETYSFDPGTPFLQMDDSRVSHD 633

  Fly   468 -ISECAFTKDDADNVVVTLYNPLAHTSTQYVRVPVKNENYEVTDEKGRVV----------ASEVV 521
             :.|....:.|:....|.::|||.......|.:.|.:....|..|:|:.:          |:::|
Mouse   634 ALPERTVIRLDSSPRFVVVFNPLEQERLSVVSLLVNSPRVRVLSEEGQPLSVQISVHWSSATDMV 698

  Fly   522 PVAWQV----------LALEFRNNDTQHELVFKASVDKIANYYIKKVASQETKNVAAHTKSKRSI 576
            |..:||          |.:.....|.......::||    ..|:..|              |.|:
Mouse   699 PDVYQVSVPVRLPGLGLGVLQLQPDLDGPYTLQSSV----RVYLNGV--------------KLSV 745

  Fly   577 KAEEANLEVPKRFKKVHSLKNATETFDDDEGETVVQTSQVKLVIDNKTGLLKTVEMNGVSENIDQ 641
            ..:.|   .|.|            ..|....:..:....:::.....|||||::..  |.|..:|
Mouse   746 SRQSA---FPVR------------VVDSGASDFAISNRYMQVWFSGLTGLLKSIRR--VDEEQEQ 793

  Fly   642 S-------YGVYRTYD-SGAYVFRQYHQADFIVQYEGVEFTVYDGALVKEVHQQFSEYISQVIRI 698
            .       ||...:.| ||||:|....:|...|..:.....|.:|....|| ..:.|:..||||:
Mouse   794 QMELEFLVYGTRTSKDKSGAYLFLPDSEAKPYVPKKPPVLRVTEGPFFSEV-AVYYEHFHQVIRL 857

  Fly   699 Y-----EGKNLVEIEWQVGPIEREEEFGREVVIIFNSTIASDGVSYTDSNG-----REMIKRVKD 753
            |     ||.:| ::.:||   :..:...:|:.:..::.|.|.|..:||.||     |:.:|::
Mouse   858 YNLPGVEGLSL-DMSFQV---DIRDYVNKELALRIHTDIDSQGTFFTDLNGFQIQPRQYLKKL-- 916

  Fly   754 QRETFTPGLDRQPTAANYYPVTSRIALQDSKKRIAVLNDRAQGGASMLNGQLELMLHRRLVRDDG 818
                        |..||:||:.....:|||::|:.:...:|.|.:|:.|||||::|.|||::||.
Mouse   917 ------------PLQANFYPMPVMAYIQDSQRRLTLHTAQALGVSSLGNGQLEVILDRRLMQDDN 969

  Fly   819 YGVGEALNEEKYGQPMIARGKVYLILSPSDESTAAEREAEKE-----------IHL--------P 864
            .|:|:.|.:.|     |...:..|:|   :..|....|..:|           .||        |
Mouse   970 RGLGQGLKDNK-----ITCNRFRLLL---ERRTTMSPEVHQEQERSTSYPSLLSHLTSMYLSTPP 1026

  Fly   865 FWKFFSKNTGSTTAAAKSVPSFNDFPKSVHLLTLE--------PFNDDEVLLRVENFLDHTEGQV 921
            .....:|..|::.|.....|..:..|...|||.|.        |..|..::|..:.|....|.:.
Mouse  1027 LVLPVAKRQGTSPALRSFHPLASPLPCDFHLLNLRMLPAEDTLPATDSALILHRKGFDCGLEAKN 1091

  Fly   922 VSFNIRPIFDYLNGVEIRETTLDGNLPLSDMKRFKFHH-DSSGQKPDAVEYFTSAHKPLAAEQSQ 985
            :.||.              ||..|.|.|..:    ||. |.:..:|.::...    .|||:
Mouse  1092 LGFNC--------------TTSQGKLALGSL----FHGLDVTFLQPTSLTLL----YPLAS---- 1130

  Fly   986 EASEFSVTLHPMQIRTFIIK 1005
            .::...::|.||:|.||.::
Mouse  1131 PSNSTDISLEPMEISTFRLR 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManVI	NP_609253.1	GH38N_AMII_LAM_like	38..312	CDD:212121	99/302 (33%)
		Alpha-mann_mid	359..434	CDD:286360	36/93 (39%)
		Glyco_hydro_38C	482..1002	CDD:285047	137/585 (23%)
Man2a2	NP_766491.2	PLN02701	140..1151	CDD:178304	299/1125 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810