DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManIV and man2a2

DIOPT Version :9

Sequence 1:	NP_609251.2	Gene:	LManIV / 34204	FlyBaseID:	FBgn0032067	Length:	978	Species:	Drosophila melanogaster
Sequence 2:	NP_001006777.1	Gene:	man2a2 / 448465	XenbaseID:	XB-GENE-981388	Length:	909	Species:	Xenopus tropicalis

Alignment Length:	777	Identity:	223/777 - (28%)
Similarity:	354/777 - (45%)	Gaps:	138/777 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 VNIHLVPHSHNDVGWLKTVDQSYYGYKNKIHHAGVQYILDSVVSQLLQDPKRRFIQVETAFFAKW 102
            :.:.:|||||||.||:||.|:.||..        .|:||:::|.:|.:||:|:||..|.:||:||
Frog   166 LQVFVVPHSHNDPGWIKTFDKYYYDQ--------TQHILNNMVVKLHEDPRRKFIWSEISFFSKW 222

  Fly   103 WNVQSESMKKVVTKLVNEGRFEFTGGAWSMNDEANVNYQGVIDQFTVGLKFLNETFGSCGRPRVG 167
            |:..:...:..|.:||..|:.|.|.|.|.|.||||.:|..:|||...|.::|.:...:  .||.|
Frog   223 WDNINSQKRAAVRRLVASGQLEMTTGGWVMPDEANTHYFAMIDQMIEGHQWLKKNLDA--TPRSG 285

  Fly   168 WQIDTFGHSREQAAIFAHMGYDGQFFSRMDHNDKDTRMNDLTMEMIWDAS-ESMSGVSLFSGMLY 231
            |.:|.||||.....|............|:.::.|.......::|.:|..: :..|...:|..|:
Frog   286 WAVDPFGHSSTMPYILRRSNLTSMLIQRVHYSIKKHFAATQSLEFMWRQTWDPDSSTDIFCHMM- 349

  Fly   232 NFYS-DTPGFC---------FD--------ILC----TDQPIIDGDSEENNVKQRVDDFISYAKN 274
            .||| |.|..|         ||        |.|    ..:.|.|     :||.:|.:..:...|.
Frog   350 PFYSYDVPHTCGPDPKICCQFDFRRLPGGRINCPWKVPPRAITD-----SNVAERANILLDQYKK 409

  Fly   275 VSEVYITNHIMVPMGGDFQYE-----DAKVNYKNMDKLIKYINER-----QASGSKYNIFYSTPS 329
            .|::|.:..::||:|.||:|:     ||:  :.|..||..|:|..     ||.       :.|.|
Frog   410 KSKLYRSKVVLVPLGDDFRYDKIQEWDAQ--FLNYQKLFDYMNSHPELHVQAQ-------FGTLS 465

  Fly   330 CYLNSLHQSL--------ESWPNKTQDFFPYAHEKNSFWTGFFTSRPTQKRFERDGNHMLQVAKQ 386
            .|.::|::.:        ..:|..:.|||.||..::.:|||::||||..|..:|.....|:.|:.
Frog   466 DYFDALYKRMGVVPGIKPPDFPVVSGDFFSYADREDHYWTGYYTSRPFYKSMDRVLESHLRGAEI 530

  Fly   387 LSVL----ANLTSEEHKIDL-DY-----LRQVMGVMQHHDAITGTEKQAVSDDYDRMMYEAIVGA 441
            |..|    |.....|.|..| ||     .|:.:|:.|||||||||.|:||..||...:..:::..
Frog   531 LYSLAINHARKAGTESKYPLSDYALLTDARRNLGLFQHHDAITGTAKEAVVIDYGVRLLHSLMNL 595

  Fly   442 SN---NARDALRLLTNMPYGEFESCLRLNISECAFTKDG----------ADNVLVTLYNPLAHSS 493
            ..   ||...|.:.....|....|....:..|...|::.          |....|.::||:..:.
Frog   596 KRIIINAAHYLVVADKEKYHYDHSVPFFSTDESRLTQESLPEKTVIKLTASPRYVVVFNPVEQNR 660

  Fly   494 TQYVRIPVKEENYQVTDEKGRTVPSEVVPVPWQVLALEYRSNDTQHELVFKATVNKVSSYSIKKV 558
            ...|.:.|...|.:|..|.|:.|.:::.|| ||.:.   ..|...:::.|.|.:..: ..||.::
Frog   661 LCVVSLLVNTYNVRVLTEDGQPVAAQLSPV-WQSVT---DMNPDVYQVSFTARLPSL-GLSIFQL 720

  Fly   559 ESSEVKHS---------------SIKK-----INPREDNNSETVVENSVVKLVMDNHTGRLKSVE 603
            .:|...|:               ||||     :...|.:..:..:||..:::.....||.|||::
Frog   721 HASIDTHTTLKSNVRVHLHGRELSIKKQDVFPVKVAESSTDDFHIENQYMQVWFSGTTGLLKSIK 785

  Fly   604 MNG--VSEKIVQNFGVYKSHT----SCAYTFRQDGDIELF--ENDFEFTVYEGSLVKEV---HQH 657
            ..|  ..:||...|.:|.:.|    |.||.|..||:.:.:  ::.....|.||....||   :||
Frog   786 RAGEEQEQKINMQFLIYGTRTSKDKSGAYLFLPDGEAKPYTPKDPPVVKVTEGPFYSEVTCQYQH 850

  Fly   658 VNDWISQVIRIY-----EGVSRVELEWMVGPIPIDDKLGSEFVTNFKSEISSNGVFYTDSNG 714
            |    .||:|:|     ||:| :::..:   |.|.|.:..|......::|.|..:|:||.||
Frog   851 V----QQVMRLYNLPGTEGLS-LDISSL---IDIRDHVNKEIAMRLSTDIQSEDIFFTDLNG 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManIV	NP_609251.2	GH38N_AMII_LAM_like	39..312	CDD:212121	96/300 (32%)
		Alpha-mann_mid	359..434	CDD:214875	35/84 (42%)
		Glyco_hydro_38C	483..973	CDD:285047	71/268 (26%)
man2a2	NP_001006777.1	PLN02701	128..>906	CDD:178304	223/777 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910