Protein Alignment LManIV and MAN2B1

DIOPT Version :10

• Sequence 1: NP_609251.2
• Gene: LManIV / 34204
• FlyBaseID: FBgn0032067
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: NP_001427499.1
• Gene: MAN2B1 / 4125
• HGNCID: 6826
• Length: 1012
• Species: Homo sapiens
• Alignment Length: 1013
• Identity: 413/1013 - (40%)
• Similarity: 590/1013 - (58%)
• Gaps: 85/1013 - (8%)

  Fly    10 LSILLVLFAKQSEAVCGYESCPETKANMVNIHLVPHSHNDVGWLKTVDQSYYGYKNKIHHAGVQY 74
            |...|:|.|.......|||:||..:.||:|:||:||:|:||||||||||.:||.||.|.||||||
Human    35 LCFFLLLLAAAGARAGGYETCPTVQPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQY 99

  Fly    75 ILDSVVSQLLQDPKRRFIQVETAFFAKWWNVQSESMKKVVTKLVNEGRFEFTGGAWSMNDEANVN 139
            |||||:|.||.||.||||.||.|||::||:.|:.:.::||..||.:||.||..|.|.|||||..:
Human   100 ILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATH 164

  Fly   140 YQGVIDQFTVGLKFLNETFGSCGRPRVGWQIDTFGHSREQAAIFAHMGYDGQFFSRMDHNDKDTR 204
            |..::||.|:||:||.:|||:.|||||.|.||.||||||||::||.||:||.||.|:|:.||..|
Human   165 YGAIVDQMTLGLRFLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVR 229

  Fly   205 MNDLTMEMIWDASESMS--GVSLFSGMLYNFYSDTPGFCFDILCTDQPII-DGDSEENNVKQRVD 266
            |..|.||.:|.||.|:.  ...||:|:|.|.|:.....|:|:||.|||:: |..|.|.|.|:.||
Human   230 MQKLEMEQVWRASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVD 294

  Fly   267 DFISYAKNVSEVYITNHIMVPMGGDFQYEDAKVNYKNMDKLIKYIN-ERQASGSKYNIFYSTPSC 330
            .|::.|......|.|||.::.||.|||||:|.:.:||:||||:.:| ::||.||..::.||||:|
Human   295 YFLNVATAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQQAKGSSVHVLYSTPAC 359

  Fly   331 YLNSLHQSLESWPNKTQDFFPYAHEKNSFWTGFFTSRPTQKRFERDGNHMLQVAKQLSVLANLTS 395
            ||..|:::..:|..|..||||||...:.||||:|:|||..||:||...:.|||..||..|..|.:
Human   360 YLWELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAA 424

  Fly   396 EEHKI---DLDYLRQVMGVMQHHDAITGTEKQAVSDDYDRMM------YEAIVGASNNARDALRL 451
            .....   |...|.:.|.|:|||||::||.:|.|::||.|.:      .|.::   :||...||.
Human   425 NVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLL---SNALARLRG 486

  Fly   452 LTNMPYGEFESCLRLNISECAFTKDGADNVLVTLYNPLAHSSTQYVRIPVKEENYQVTDEKGRTV 516
            ..:    .|..|.:||||.|..::..| ...|.:||||.......||:||.|..:.|.|..||||
Human   487 FKD----HFTFCQQLNISICPLSQTAA-RFQVIVYNPLGRKVNWMVRLPVSEGVFVVKDPNGRTV 546

  Fly   517 PSEVVPVPWQVLALEYRSNDTQ-H--ELVFKATVNKV--SSYSIKKVESSEVKHSSIKKINPRED 576
            ||:||..|         |:|:| |  ||:|.|::..:  |:||:.:|...:.:..:.:.| ||..
Human   547 PSDVVIFP---------SSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPI-PRRS 601

  Fly   577 NNSETVVENSVVKLVMDNHTGRLKSVEMNGVSEKIV----QNFGVYKS--------HTSCAYTFR 629
            .:....:||..::...|..||.|  :|:..::::::    |.|..|.:        ..|.||.||
Human   602 WSPALTIENEHIRATFDPDTGLL--MEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFR 664

  Fly   630 QDGDIELFENDF-EFTVYEGSLVKEVHQHVNDWISQVIRIYEGVSRVELEWMVGPIPIDDKLGSE 693
            .:....|..:.: :..:.:..||:||||:.:.|.|||:|:|.|...:||||.|||||:.|..|.|
Human   665 PNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIPVGDTWGKE 729

  Fly   694 FVTNFKSEISSNGVFYTDSNGRELMKRVKDKREDFVSDLSRQPVSGNFYPVTSRIALQDDTKRLV 758
            .::.|.:.:.:.|.|||||||||:::|.:|.|..:..: ..:||:||:|||.:||.:.|...:|.
Human   730 VISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLN-QTEPVAGNYYPVNTRIYITDGNMQLT 793

  Fly   759 LLNDRSQGGASLEDGALEMLIHRRHLFNDGGGVGEALNETQYGKGLIARGKLYLILDSATDGDTV 823
            :|.||||||:||.||:||:::|||.|.:||.||.|.|.|.  |.|...||:..::||:|......
Human   794 VLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMEN--GSGAWVRGRHLVLLDTAQAAAAG 856

  Fly   824 TERKTEKELFLPFWKFFSKTGGVEI---TPSKSLPDFN----DLPQSVHLLTLEFFSEQEILIRF 881
            .....|:|:..| ....:..||...   .|.::  .|:    |||.|||||||..:..:.:|:|.
Human   857 HRLLAEQEVLAP-QVVLAPGGGAAYNLGAPPRT--QFSGLRRDLPPSVHLLTLASWGPEMVLLRL 918

  Fly   882 EH--FLDKSEGRVIS----FNIRDIFDSLGGLAIRETTLDGNMPLSDMKRFKFHAQESGTKPSSV 940
            ||  .:.:..||.:|    .|:||:|.:.....::||||..|.......|.|: ...:|..|...
Human   919 EHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQLREAASRLKW-TTNTGPTPHQT 982

  Fly   941 EYSTAQHKPLEAVKSDEASLFAVTLYPMQIRTFIIKTE 978
            .|           :.|.|:   :||.||:||||:...:
Human   983 PY-----------QLDPAN---ITLEPMEIRTFLASVQ 1006

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManIV	NP_609251.2	PLN02701	31..793	CDD:178304	347/792 (44%)
		GH38N_AMII_LAM_like	39..312	CDD:212121	152/275 (55%)
MAN2B1	NP_001427499.1	None