DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManIV and MAN2B1

DIOPT Version :9

Sequence 1:	NP_609251.2	Gene:	LManIV / 34204	FlyBaseID:	FBgn0032067	Length:	978	Species:	Drosophila melanogaster
Sequence 2:	XP_005259970.1	Gene:	MAN2B1 / 4125	HGNCID:	6826	Length:	1012	Species:	Homo sapiens

Alignment Length:	1013	Identity:	413/1013 - (40%)
Similarity:	590/1013 - (58%)	Gaps:	85/1013 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LSILLVLFAKQSEAVCGYESCPETKANMVNIHLVPHSHNDVGWLKTVDQSYYGYKNKIHHAGVQY 74
            |...|:|.|.......|||:||..:.||:|:||:||:|:||||||||||.:||.||.|.||||||
Human    35 LCFFLLLLAAAGARAGGYETCPTVQPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQY 99

  Fly    75 ILDSVVSQLLQDPKRRFIQVETAFFAKWWNVQSESMKKVVTKLVNEGRFEFTGGAWSMNDEANVN 139
            |||||:|.||.||.||||.||.|||::||:.|:.:.::||..||.:||.||..|.|.|||||..:
Human   100 ILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATH 164

  Fly   140 YQGVIDQFTVGLKFLNETFGSCGRPRVGWQIDTFGHSREQAAIFAHMGYDGQFFSRMDHNDKDTR 204
            |..::||.|:||:||.:|||:.|||||.|.||.||||||||::||.||:||.||.|:|:.||..|
Human   165 YGAIVDQMTLGLRFLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVR 229

  Fly   205 MNDLTMEMIWDASESMS--GVSLFSGMLYNFYSDTPGFCFDILCTDQPII-DGDSEENNVKQRVD 266
            |..|.||.:|.||.|:.  ...||:|:|.|.|:.....|:|:||.|||:: |..|.|.|.|:.||
Human   230 MQKLEMEQVWRASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVD 294

  Fly   267 DFISYAKNVSEVYITNHIMVPMGGDFQYEDAKVNYKNMDKLIKYIN-ERQASGSKYNIFYSTPSC 330
            .|::.|......|.|||.::.||.|||||:|.:.:||:||||:.:| ::||.||..::.||||:|
Human   295 YFLNVATAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQQAKGSSVHVLYSTPAC 359

  Fly   331 YLNSLHQSLESWPNKTQDFFPYAHEKNSFWTGFFTSRPTQKRFERDGNHMLQVAKQLSVLANLTS 395
            ||..|:::..:|..|..||||||...:.||||:|:|||..||:||...:.|||..||..|..|.:
Human   360 YLWELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAA 424

  Fly   396 EEHKI---DLDYLRQVMGVMQHHDAITGTEKQAVSDDYDRMM------YEAIVGASNNARDALRL 451
            .....   |...|.:.|.|:|||||::||.:|.|::||.|.:      .|.::   :||...||.
Human   425 NVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLL---SNALARLRG 486

  Fly   452 LTNMPYGEFESCLRLNISECAFTKDGADNVLVTLYNPLAHSSTQYVRIPVKEENYQVTDEKGRTV 516
            ..:    .|..|.:||||.|..::..| ...|.:||||.......||:||.|..:.|.|..||||
Human   487 FKD----HFTFCQQLNISICPLSQTAA-RFQVIVYNPLGRKVNWMVRLPVSEGVFVVKDPNGRTV 546

  Fly   517 PSEVVPVPWQVLALEYRSNDTQ-H--ELVFKATVNKV--SSYSIKKVESSEVKHSSIKKINPRED 576
            ||:||..|         |:|:| |  ||:|.|::..:  |:||:.:|...:.:..:.:.| ||..
Human   547 PSDVVIFP---------SSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPI-PRRS 601

  Fly   577 NNSETVVENSVVKLVMDNHTGRLKSVEMNGVSEKIV----QNFGVYKS--------HTSCAYTFR 629
            .:....:||..::...|..||.|  :|:..::::::    |.|..|.:        ..|.||.||
Human   602 WSPALTIENEHIRATFDPDTGLL--MEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFR 664

  Fly   630 QDGDIELFENDF-EFTVYEGSLVKEVHQHVNDWISQVIRIYEGVSRVELEWMVGPIPIDDKLGSE 693
            .:....|..:.: :..:.:..||:||||:.:.|.|||:|:|.|...:||||.|||||:.|..|.|
Human   665 PNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIPVGDTWGKE 729

  Fly   694 FVTNFKSEISSNGVFYTDSNGRELMKRVKDKREDFVSDLSRQPVSGNFYPVTSRIALQDDTKRLV 758
            .::.|.:.:.:.|.|||||||||:::|.:|.|..:..: ..:||:||:|||.:||.:.|...:|.
Human   730 VISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLN-QTEPVAGNYYPVNTRIYITDGNMQLT 793

  Fly   759 LLNDRSQGGASLEDGALEMLIHRRHLFNDGGGVGEALNETQYGKGLIARGKLYLILDSATDGDTV 823
            :|.||||||:||.||:||:::|||.|.:||.||.|.|.|.  |.|...||:..::||:|......
Human   794 VLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMEN--GSGAWVRGRHLVLLDTAQAAAAG 856

  Fly   824 TERKTEKELFLPFWKFFSKTGGVEI---TPSKSLPDFN----DLPQSVHLLTLEFFSEQEILIRF 881
            .....|:|:..| ....:..||...   .|.::  .|:    |||.|||||||..:..:.:|:|.
Human   857 HRLLAEQEVLAP-QVVLAPGGGAAYNLGAPPRT--QFSGLRRDLPPSVHLLTLASWGPEMVLLRL 918

  Fly   882 EH--FLDKSEGRVIS----FNIRDIFDSLGGLAIRETTLDGNMPLSDMKRFKFHAQESGTKPSSV 940
            ||  .:.:..||.:|    .|:||:|.:.....::||||..|.......|.|: ...:|..|...
Human   919 EHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQLREAASRLKW-TTNTGPTPHQT 982

  Fly   941 EYSTAQHKPLEAVKSDEASLFAVTLYPMQIRTFIIKTE 978
            .|           :.|.|:   :||.||:||||:...:
Human   983 PY-----------QLDPAN---ITLEPMEIRTFLASVQ 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManIV	NP_609251.2	GH38N_AMII_LAM_like	39..312	CDD:212121	152/275 (55%)
		Alpha-mann_mid	359..434	CDD:214875	35/77 (45%)
		Glyco_hydro_38C	483..973	CDD:285047	179/520 (34%)
MAN2B1	XP_005259970.1	PLN02701	63..1001	CDD:178304	400/978 (41%)
		GH38N_AMII_LAM_like	63..341	CDD:212121	152/277 (55%)
		Alpha-mann_mid	388..466	CDD:214875	35/77 (45%)
		Glyco_hydro_38C	511..1001	CDD:285047	179/522 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8339
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	811	1.000	Inparanoid score	I487
Isobase	1	0.950	-	0	Normalized mean entropy	S4230
OMA	1	1.010	-	-		QHG55625
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm40555
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790