Protein Alignment LManIV and Man2b1

DIOPT Version :10

• Sequence 1: NP_609251.2
• Gene: LManIV / 34204
• FlyBaseID: FBgn0032067
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: XP_006255335.1
• Gene: Man2b1 / 361378
• RGDID: 3039
• Length: 1021
• Species: Rattus norvegicus
• Alignment Length: 1025
• Identity: 406/1025 - (39%)
• Similarity: 577/1025 - (56%)
• Gaps: 92/1025 - (8%)

  Fly     7 ILFLSILL-VLFAKQSEAVCGYESCPETKANMVNIHLVPHSHNDVGWLKTVDQSYYG-------- 62
            :|.:|.|: :|.|.......||::||.||..|:|:||:||:|:||||||||||.|||
  Rat    31 VLSISFLIWLLLAAPGAQAAGYKTCPTTKPGMLNVHLLPHTHDDVGWLKTVDQYYYGMDPHLLTF 95

  Fly    63 ---YKNKIHHAGVQYILDSVVSQLLQDPKRRFIQVETAFFAKWWNVQSESMKKVVTKLVNEGRFE 124
               ..:.:.||.||||||||:..||.||.||||.||.|||::||..|:...:..|..||.:||.|
  Rat    96 MPIVMSDVQHASVQYILDSVIYSLLNDPTRRFIYVEMAFFSRWWKQQTNVTQDAVRNLVRQGRLE 160

  Fly   125 FTGGAWSMNDEANVNYQGVIDQFTVGLKFLNETFGSCGRPRVGWQIDTFGHSREQAAIFAHMGYD 189
            |..|.|.|||||..:|..::||.|:||:||.:||||.|.|||.|.||.||||||||::||.||:|
  Rat   161 FVNGGWVMNDEAATHYGAIVDQMTLGLRFLQDTFGSDGLPRVAWHIDPFGHSREQASLFAQMGFD 225

  Fly   190 GQFFSRMDHNDKDTRMNDLTMEMIWDASESMS--GVSLFSGMLYNFYSDTPGFCFDILCTDQPII 252
            |.|..|:|:.||..|...|.||.:|.||.|:.  ...||:|:|.|.|:.....|:|:||||.|::
  Rat   226 GFFLGRIDYQDKFNRKRKLKMEELWRASASLKPPAADLFTGVLPNNYNPPKDLCWDVLCTDPPVV 290

  Fly   253 DG-DSEENNVKQRVDDFISYAKNVSEVYITNHIMVPMGGDFQYEDAKVNYKNMDKLIKYINE-RQ 315
            |. .|.|.|..:.||.|::.|.:..:.|.|||.::.||.|||||:|.:.:|||||||:.:|| :|
  Rat   291 DDPTSPEFNANKLVDYFLNLASSQKKYYRTNHTVMTMGSDFQYENANMWFKNMDKLIRLVNEQQQ 355

  Fly   316 ASGSKYNIFYSTPSCYLNSLHQSLESWPNKTQDFFPYAHEKNSFWTGFFTSRPTQKRFERDGNHM 380
            |:|||.::.||||||||..|:::..:|..|..||||||...:.||||:|:|||..||:||...:.
  Rat   356 ANGSKVHVLYSTPSCYLWELNKANLTWTVKEDDFFPYADGPHMFWTGYFSSRPALKRYERLSYNF 420

  Fly   381 LQVAKQLSVLANLTSEEHKI------DLDYLRQVMGVMQHHDAITGTEKQAVSDDYDRMM----- 434
            |||..||..   |...|.|:      |...|.:.|.|:|||||:|||.:|.|.:||.:.:
  Rat   421 LQVCNQLEA---LVGPEAKVGPYGSGDSAPLNEAMAVLQHHDAVTGTARQNVVNDYAKQLAAGWG 482

  Fly   435 -YEAIVGASNNARDALRLLTNMPYGEFESCLRLNISECAFTKDGADNVLVTLYNPLAHSSTQYVR 498
             .|.:|   :||...|.|...    .|..|..:|||.|..::. :::..|.:|||:.......||
  Rat   483 PCEVLV---SNALARLSLYKQ----NFSFCREINISICPASQT-SEHFRVIIYNPVGRKVDLMVR 539

  Fly   499 IPVKEENYQVTDEKGRTVPSEVVPVPWQVLALEYRSNDTQHELVFKATVNKV--SSYSIKKVESS 561
            :||.|..:.|.|...|.:.|.||.||      ...|...|.||:|.|:|..:  |.||:.|:...
  Rat   540 LPVSEGIFLVKDPNDRRISSNVVMVP------SAYSKTYQWELLFPASVPALGFSIYSVNKMSGH 598

  Fly   562 EVKHSSIKKINPREDNNSETVVENSVVKLVMDNHTGRLKSVE--MNGVSEKIVQNFGVYKS---- 620
            ..:..:: ...|::..:...|:||..::...|:.||.|:.:|  ...:|..:.|.|..|.:
  Rat   599 NHQAHNL-TARPKKSKSRVLVIENKYIRATFDSDTGLLRKIENLEQNISLPVRQGFFWYNASAGD 662

  Fly   621 ----HTSCAYTFRQDGDIELFENDF-EFTVYEGSLVKEVHQHVNDWISQVIRIYEGVSRVELEWM 680
                ..|.||.||......|..:.: :.|:.:.:||:||||:.:.|.|||||:|||...:||||.
  Rat   663 EESPQASGAYIFRPSHRKPLPVSHWAQVTLVKTNLVQEVHQNFSAWCSQVIRLYEGQRHLELEWT 727

  Fly   681 VGPIPIDDKLGSEFVTNFKSEISSNGVFYTDSNGRELMKRVKDKREDFVSDLSRQPVSGNFYPVT 745
            |||||:.|..|.|.::.|.:.:.:.|.|:|||||||::||..|.|..:..: ..:||:||:|||.
  Rat   728 VGPIPVKDDWGKEVISRFNTPMRTRGQFFTDSNGREILKRRDDFRPTWTLN-QTEPVAGNYYPVN 791

  Fly   746 SRIALQDDTKRLVLLNDRSQGGASLEDGALEMLIHRRHLFNDGGGVGEALNETQYGKGLIARGKL 810
            :||.:.|...:|.:|.||||||:||.||:||:::|||.|.:|..||.|.|.||..|..:  ||:.
  Rat   792 TRIYITDGHMQLTVLTDRSQGGSSLLDGSLELMVHRRLLVDDERGVAEPLLETDTGDKV--RGRH 854

  Fly   811 YLILDSATDGDTVTERKTEKELFLPFWKFFSKTGGVEITPSKSLPDF------NDLPQSVHLLTL 869
            .:||.|.:|.........|:|:..|  :.....||.....|:: |..      .:||..||||||
  Rat   855 LVILSSVSDAAARHRLLAEQEVLAP--QVVLAHGGSSPYHSQA-PKMQFSALRRELPPQVHLLTL 916

  Fly   870 EFFSEQEILIRFEH-FLDKSEGR-----VISFNIRDIFDSLGGLAIRETTLDGNMPLSDMKRFKF 928
            ..:..:.:|:|.|| |..|.:..     .::.|::::|.:.....::||||..|.|||.:.|.|:
  Rat   917 ARWGPKMLLLRLEHQFAVKEDSNRNLSSPVTLNLQNLFKTFTINYLQETTLAANQPLSRVSRLKW 981

  Fly   929 HAQESGTKPSSVEYSTAQHKPLEAVKSDEASLFAVTLYPMQIRTFIIKTE 978
            .     |....:.|....       :.|..|   :||.|||||||:...:
  Rat   982 M-----TDTGPISYPAPS-------RLDPTS---ITLQPMQIRTFLASVQ 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManIV	NP_609251.2	PLN02701	31..793	CDD:178304	341/801 (43%)
		GH38N_AMII_LAM_like	39..312	CDD:212121	145/286 (51%)
Man2b1	XP_006255335.1	PLN02701	63..916	CDD:178304	361/876 (41%)
		GH38N_AMII_LAM_like	63..351	CDD:212121	145/287 (51%)