Protein Alignment LManIV and Man2a2

DIOPT Version :10

• Sequence 1: NP_609251.2
• Gene: LManIV / 34204
• FlyBaseID: FBgn0032067
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: NP_001425115.1
• Gene: Man2a2 / 308757
• RGDID: 1310238
• Length: 1175
• Species: Rattus norvegicus
• Alignment Length: 1094
• Identity: 276/1094 - (25%)
• Similarity: 450/1094 - (41%)
• Gaps: 235/1094 - (21%)

  Fly    35 ANMVNIHLVPHSHNDVGWLKTVDQSYYGYKNKIHHAGVQYILDSVVSQLLQDPKRRFIQVETAFF 99
            |..:.:.:|||||||.||:||.|: ||..:       .|:||:|:||:|.:||:|||:..|.:||
  Rat   163 AEDLQVFVVPHSHNDPGWIKTFDK-YYTEQ-------TQHILNSMVSKLQEDPRRRFLWAEVSFF 219

  Fly   100 AKWWNVQSESMKKVVTKLVNEGRFEFTGGAWSMNDEANVNYQGVIDQFTVGLKFLNETFGSCGRP 164
            ||||:..|...:..|.:||..|:.|...|.|.|.||||.:|..::||...|.::|....|:  .|
  Rat   220 AKWWDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLERNLGA--TP 282

  Fly   165 RVGWQIDTFGHSREQAAIFAHMGYDGQFFSRMDHNDKDTRMNDLTMEMIWDAS-ESMSGVSLFSG 228
            |.||.:|.||||.....:............|:.:..|.......::|.:|..: :|.|...:|..
  Rat   283 RSGWAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCH 347

  Fly   229 MLYNFYS-DTPGFCF---DILCT-DQPIIDGDS------------EENNVKQRVDDFISYAKNVS 276
            |: .||| |.|..|.   .|.|. |...:.|..            .|.||..|....:...:..|
  Rat   348 MM-PFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVADRAALLLDQYRKKS 411

  Fly   277 EVYITNHIMVPMGGDFQYE-----DAKVNYKNMDKLIKYINER-----QASGSKYNIFYSTPSCY 331
            .::.::.::||:|.||:|:     ||:  :.|..:|..::|.:     ||.       :.|.|.|
  Rat   412 RLFRSSVLLVPLGDDFRYDKPQEWDAQ--FFNYQRLFDFLNSKPEFHVQAQ-------FGTLSEY 467

  Fly   332 LNSLHQSL--------ESWPNKTQDFFPYAHEKNSFWTGFFTSRPTQKRFERDGNHMLQVAKQLS 388
            .::|::..        ..:|..:.|||.||..::.:|||::||||..|..:|.....|:.|:.|.
  Rat   468 FDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLETHLRGAEVLY 532

  Fly   389 VLA-------NLTSEEHKID---LDYLRQVMGVMQHHDAITGTEKQAVSDDYDRMMYEAIVGASN 443
            .||       .||.:....|   |...|:.:|:.|||||||||.|:||..||...:..::|....
  Rat   533 SLALAHARRSGLTGQYPLSDYAVLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVSLKQ 597

  Fly   444 ---NARDALRLLTNMPYGEFESCLRLNISECAFTKDG----------ADNVLVTLYNPLAHSSTQ 495
               ||...|.|.....|........|.:.:...:.|.          :....|.::|||......
  Rat   598 VIINAAHYLVLGDKETYSFDPRAPFLQMDDSRVSHDALPERTVIRLDSSPRFVVVFNPLEQERLS 662

  Fly   496 YVRIPVKEENYQVTDEKGRTVPSEV------------------VPVPWQVLAL-----------E 531
            .|.:.|.....:|..|:|:.:..::                  |||....|.|           .
  Rat   663 VVSLLVNSPRVRVLSEEGQPLSVQISVQWSSATNMVPDVYQVSVPVRLPALGLGVLQLQPDLDGP 727

  Fly   532 YRSNDTQHELV--FKATVNKVSSYSIKKVESSEVKHSSIKKINPREDNNSETVVENSVVKLVMDN 594
            |....:.|..:  .|.:|::.:::.::.|:|                ..|:..:.|..:::....
  Rat   728 YTLQSSVHVYLNGVKLSVSRQTTFPLRVVDS----------------GTSDFAISNRYMQVWFSG 776

  Fly   595 HTGRLKSVEMNGVSEKIVQNFG----VYKSHT----SCAYTFRQDGDIELF--ENDFEFTVYEGS 649
            .||.||||..  |.|:..|...    ||.:.|    |.||.|..|.:.:.:  :......|.||.
  Rat   777 LTGLLKSVRR--VDEEQEQQVDMKLFVYGTRTSKDKSGAYLFLPDNEAKPYVPKKPPVLRVTEGP 839

  Fly   650 LVKEV---HQHVNDWISQVIRIYE--GVSRVELEWMVGPIPIDDKLGSEFVTNFKSEISSNGVFY 709
            ...||   ::|.:    ||||:|.  ||..:.|: :...:.|.|.:..|......::|.|.|.|:
  Rat   840 FFSEVAAYYEHFH----QVIRLYNLPGVEGLSLD-VSFQVDIRDYVNKELALRIHTDIDSQGTFF 899

  Fly   710 TDSNGRELMKRVKDKREDFVSDLSRQPVSGNFYPVTSRIALQDDTKRLVLLNDRSQGGASLEDGA 774
            ||.||.::..|         ..|.:.|:..||||:.....:||..:||.|...::.|.:||.:|.
  Rat   900 TDLNGFQVQPR---------KYLKKLPLQANFYPMPVMAYIQDSQRRLTLHTAQALGVSSLGNGQ 955

  Fly   775 LEMLIHRRHLFNDGGGVGEALNETQYGKGLIARGKLYLILDSAT--------------------- 818
            ||:::.||.:.:|..|:|:.|.:.:     |......|:|:..|
  Rat   956 LEVILDRRLMQDDNRGLGQGLKDNK-----ITCNHFRLLLERRTLMSPEPGFFSKLAAMFRGLIF 1015

  Fly   819 DGDTVTERKTEKELFLPFWKFFSKTGGVEI-TP------------SKSLPDF----NDLPQSVHL 866
            ..:|:...|.::|....:....|....:.: ||            |.:|..|    :.||...||
  Rat  1016 SSNTIRNSKVQQERSTSYPSLLSHMTSMYLNTPPLVLPVAKRESTSPTLHSFHPLASPLPCDFHL 1080

  Fly   867 LTLEFFSEQE--------ILIRFEHFLDKSEGRVISFNIRDIFDSLGGLAIRETTLDGNMPLSDM 923
            |.|.....::        :::..:.|....|.:.:.||.              ||..|.:.|..:
  Rat  1081 LNLRMLPAEDTLPAADAALILHRKGFDCGLEAKNLGFNC--------------TTSQGKLALGSL 1131

  Fly   924 KRFKFHAQE-SGTKPSSVEYSTAQHKPLEAVKSDEASLFAVTLYPMQIRTFIIK 976
                ||..: ...:|:|:........|..:..        ::|.||:|.||.::
  Rat  1132 ----FHGLDVLFLQPTSLTLLYPLASPSNSTD--------ISLEPMEISTFRLR 1173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManIV	NP_609251.2	PLN02701	31..793	CDD:178304	236/862 (27%)
		GH38N_AMII_LAM_like	39..312	CDD:212121	94/295 (32%)
Man2a2	NP_001425115.1	None