DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManIV and aman-2

DIOPT Version :9

Sequence 1:	NP_609251.2	Gene:	LManIV / 34204	FlyBaseID:	FBgn0032067	Length:	978	Species:	Drosophila melanogaster
Sequence 2:	NP_505995.2	Gene:	aman-2 / 179632	WormBaseID:	WBGene00010284	Length:	1145	Species:	Caenorhabditis elegans

Alignment Length:	936	Identity:	239/936 - (25%)
Similarity:	411/936 - (43%)	Gaps:	171/936 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 VNIHLVPHSHNDVGWLKTVDQSYYGYKNKIHHAGVQYILDSVVSQLLQDPKRRFIQVETAFFAKW 102
            :.:.::||||.|.||:.|.:: ||..:.:       .|||.:...|.:..:.|||..|.:||..|
Worm   181 LEVIVIPHSHCDPGWIMTFEE-YYNRQTR-------NILDGMAKHLAEKDEMRFIYAEISFFETW 237

  Fly   103 WNVQSESMKKVVTKLVNEGRFEFTGGAWSMNDEANVNYQGVIDQFTVGLKFLNETFGSCGRPRVG 167
            |..|::.:||.|...:..|:||...|.|.|.||||.:|..:|.:...|.:::....|....|:..
Worm   238 WRDQADEIKKKVKGYLEAGKFEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSH 302

  Fly   168 WQIDTFGHSREQAAIFAHMGYDGQFFSRMDHNDKDTRMNDLTMEMIWDASESMSGVSLFSGMLYN 232
            |.||.||.|.....:............|:.::.|........:|..|......:|.......:..
Worm   303 WSIDPFGLSPSMPHLLTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLRSHIMP 367

  Fly   233 FYS-DTPGFC---------FDI--------LCTDQPIIDGDSEENNVKQRVDDFISYAKNVSEVY 279
            ||| |.|..|         ||.        .| |..|......::||..|.:......:..|:::
Worm   368 FYSYDIPHTCGPEPSVCCQFDFRRMPEGGKSC-DWGIPPQKINDDNVAHRAEMIYDQYRKKSQLF 431

  Fly   280 ITNHIMVPMGGDFQYE-DAKVN--YKNMDKLIKYINERQASGSKYNIF--YSTPSCYLNSLHQSL 339
            ..|.|..|:|.||:|: |.:.|  |:|..||.:|:|    |.|::|:.  :.|.|.|...|..::
Worm   432 KNNVIFQPLGDDFRYDIDFEWNSQYENYKKLFEYMN----SKSEWNVHAQFGTLSDYFKKLDTAI 492

  Fly   340 ----ESWPNKTQDFFPYAHEKNSFWTGFFTSRPTQKRFERDGNHMLQVAKQLSVLANLTSE---E 397
                |..|..:.|||.||...:.:|:|:|||||..|:.:|...|.|:.|:....|||:..|   |
Worm   493 SASGEQLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAEIAFTLANIEEEGMVE 557

  Fly   398 HKI--DLDYLRQVMGVMQHHDAITGTEKQAVSDDYDRMMYEAIVGASNNARDALRLLTNMPYGEF 460
            .||  .|...|:.:.:.||||.:|||.|..|..||.:.|.:|:....:...:||.:|..:
Worm   558 AKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNACEDILSEALVVLLGI----- 617

  Fly   461 ESCLRLNISECAFTKDGADNVL-----------VTLYNPLAHSSTQYVRI-------------PV 501
            :|..::.:.|....    :|:|           |.|:|.|:.:..:.:.|             |:
Worm   618 DSTNKMQMDEHRVN----ENLLPEKRVYKIGQNVVLFNTLSRNRNEPICIQVDSLDAGVEADPPI 678

  Fly   502 KEENYQVT-----DEKGRTVPSEVVPVPWQVLALEYRSNDTQHELVFKATVNKVSSYSIK----- 556
            |::  ||:     ||:.:|:   ||             .:...||.|..::..:.|.|.:
Worm   679 KKQ--QVSPVIAYDEEKKTL---VV-------------KNGIFELCFMLSLGPMESVSFRLVKNT 725

  Fly   557 ---KVE-----SSEVKHSSIKKINPREDNNSETVVENSVVKLVMDNHTGRLKSVEMNGVSEKIVQ 613
               |||     ::|.|.:|.|.    ...:.:..|:|..|:...|...|.:|.. .:.|.:|.:.
Worm   726 TTSKVEIITNNAAEFKETSFKS----SSTSGDFTVKNDKVEAEFDGENGMIKRA-TSLVDDKPID 785

  Fly   614 ------NFGVYKS----------HTSCAYTFRQDGDI-ELFENDFEFTVYEGSLVKEVHQHVND- 660
                  ::|..||          :.:.||.|..||:. ||.:...::.:.:|.:|::|....|:
Worm   786 LNSHFIHYGARKSKRKFANGNEDNPAGAYLFLPDGEARELKKQSSDWILVKGEVVQKVFATPNND 850

  Fly   661 -WISQVIRIYEGVSRVELEWMVGPIPIDDKLGSEFVTNFKSEISSNGVFYTDSNGRELMKRVKDK 724
             .|.|...:|:|:..::|:   ..:.:..|...|....|.|.::|...|:||.||.:::||   :
Worm   851 LKILQTYTLYQGLPWIDLD---NEVDVRSKENFELALRFSSSVNSGDEFFTDLNGMQMIKR---R 909

  Fly   725 REDFVSDLSRQPVSGNFYPVTSRIALQDDTKRLVLLNDRSQGGASLEDGALEMLIHRRHLFNDGG 789
            |:      ::.|...||||:::.:.::|||.|:.:.:.::.|.:||..|.:|:::.||...:|..
Worm   910 RQ------TKLPTQANFYPMSAGVYIEDDTTRMSIHSAQALGVSSLSSGQIEIMLDRRLSSDDNR 968

  Fly   790 GVGEALNETQYGKGLIARGKLYLILDSATDGDTVTER---------KTEKELFLPFWKFFSKTGG 845
            |:.:.:.:   .|..:|..::.:...|::.|:...||         .....|..|..|...
Worm   969 GLQQGVRD---NKRTVAHFRIVIEPMSSSSGNKKEERVGFHSHVGHLATWSLHYPLVKMIG---- 1026

  Fly   846 VEITPSKSLPDFN---DLPQSVHLLT 868
             :.|| ||:...|   :|...:||:|
Worm  1027 -DATP-KSISSKNVEQELNCDLHLVT 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManIV	NP_609251.2	GH38N_AMII_LAM_like	39..312	CDD:212121	81/293 (28%)
		Alpha-mann_mid	359..434	CDD:214875	32/79 (41%)
		Glyco_hydro_38C	483..973	CDD:285047	102/448 (23%)
aman-2	NP_505995.2	PLN02701	142..1124	CDD:178304	239/936 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810