Protein Alignment LManIV and aman-2

DIOPT Version :10

• Sequence 1: NP_609251.2
• Gene: LManIV / 34204
• FlyBaseID: FBgn0032067
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: NP_505995.2
• Gene: aman-2 / 179632
• WormBaseID: WBGene00010284
• Length: 1145
• Species: Caenorhabditis elegans
• Alignment Length: 936
• Identity: 239/936 - (25%)
• Similarity: 411/936 - (43%)
• Gaps: 171/936 - (18%)

  Fly    38 VNIHLVPHSHNDVGWLKTVDQSYYGYKNKIHHAGVQYILDSVVSQLLQDPKRRFIQVETAFFAKW 102
            :.:.::||||.|.||:.|.:: ||..:.:       .|||.:...|.:..:.|||..|.:||..|
 Worm   181 LEVIVIPHSHCDPGWIMTFEE-YYNRQTR-------NILDGMAKHLAEKDEMRFIYAEISFFETW 237

  Fly   103 WNVQSESMKKVVTKLVNEGRFEFTGGAWSMNDEANVNYQGVIDQFTVGLKFLNETFGSCGRPRVG 167
            |..|::.:||.|...:..|:||...|.|.|.||||.:|..:|.:...|.:::....|....|:..
 Worm   238 WRDQADEIKKKVKGYLEAGKFEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSH 302

  Fly   168 WQIDTFGHSREQAAIFAHMGYDGQFFSRMDHNDKDTRMNDLTMEMIWDASESMSGVSLFSGMLYN 232
            |.||.||.|.....:............|:.::.|........:|..|......:|.......:..
 Worm   303 WSIDPFGLSPSMPHLLTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLRSHIMP 367

  Fly   233 FYS-DTPGFC---------FDI--------LCTDQPIIDGDSEENNVKQRVDDFISYAKNVSEVY 279
            ||| |.|..|         ||.        .| |..|......::||..|.:......:..|:::
 Worm   368 FYSYDIPHTCGPEPSVCCQFDFRRMPEGGKSC-DWGIPPQKINDDNVAHRAEMIYDQYRKKSQLF 431

  Fly   280 ITNHIMVPMGGDFQYE-DAKVN--YKNMDKLIKYINERQASGSKYNIF--YSTPSCYLNSLHQSL 339
            ..|.|..|:|.||:|: |.:.|  |:|..||.:|:|    |.|::|:.  :.|.|.|...|..::
 Worm   432 KNNVIFQPLGDDFRYDIDFEWNSQYENYKKLFEYMN----SKSEWNVHAQFGTLSDYFKKLDTAI 492

  Fly   340 ----ESWPNKTQDFFPYAHEKNSFWTGFFTSRPTQKRFERDGNHMLQVAKQLSVLANLTSE---E 397
                |..|..:.|||.||...:.:|:|:|||||..|:.:|...|.|:.|:....|||:..|   |
 Worm   493 SASGEQLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAEIAFTLANIEEEGMVE 557

  Fly   398 HKI--DLDYLRQVMGVMQHHDAITGTEKQAVSDDYDRMMYEAIVGASNNARDALRLLTNMPYGEF 460
            .||  .|...|:.:.:.||||.:|||.|..|..||.:.|.:|:....:...:||.:|..:
 Worm   558 AKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNACEDILSEALVVLLGI----- 617

  Fly   461 ESCLRLNISECAFTKDGADNVL-----------VTLYNPLAHSSTQYVRI-------------PV 501
            :|..::.:.|....    :|:|           |.|:|.|:.:..:.:.|             |:
 Worm   618 DSTNKMQMDEHRVN----ENLLPEKRVYKIGQNVVLFNTLSRNRNEPICIQVDSLDAGVEADPPI 678

  Fly   502 KEENYQVT-----DEKGRTVPSEVVPVPWQVLALEYRSNDTQHELVFKATVNKVSSYSIK----- 556
            |::  ||:     ||:.:|:   ||             .:...||.|..::..:.|.|.:
 Worm   679 KKQ--QVSPVIAYDEEKKTL---VV-------------KNGIFELCFMLSLGPMESVSFRLVKNT 725

  Fly   557 ---KVE-----SSEVKHSSIKKINPREDNNSETVVENSVVKLVMDNHTGRLKSVEMNGVSEKIVQ 613
               |||     ::|.|.:|.|.    ...:.:..|:|..|:...|...|.:|.. .:.|.:|.:.
 Worm   726 TTSKVEIITNNAAEFKETSFKS----SSTSGDFTVKNDKVEAEFDGENGMIKRA-TSLVDDKPID 785

  Fly   614 ------NFGVYKS----------HTSCAYTFRQDGDI-ELFENDFEFTVYEGSLVKEVHQHVND- 660
                  ::|..||          :.:.||.|..||:. ||.:...::.:.:|.:|::|....|:
 Worm   786 LNSHFIHYGARKSKRKFANGNEDNPAGAYLFLPDGEARELKKQSSDWILVKGEVVQKVFATPNND 850

  Fly   661 -WISQVIRIYEGVSRVELEWMVGPIPIDDKLGSEFVTNFKSEISSNGVFYTDSNGRELMKRVKDK 724
             .|.|...:|:|:..::|:   ..:.:..|...|....|.|.::|...|:||.||.:::||   :
 Worm   851 LKILQTYTLYQGLPWIDLD---NEVDVRSKENFELALRFSSSVNSGDEFFTDLNGMQMIKR---R 909

  Fly   725 REDFVSDLSRQPVSGNFYPVTSRIALQDDTKRLVLLNDRSQGGASLEDGALEMLIHRRHLFNDGG 789
            |:      ::.|...||||:::.:.::|||.|:.:.:.::.|.:||..|.:|:::.||...:|..
 Worm   910 RQ------TKLPTQANFYPMSAGVYIEDDTTRMSIHSAQALGVSSLSSGQIEIMLDRRLSSDDNR 968

  Fly   790 GVGEALNETQYGKGLIARGKLYLILDSATDGDTVTER---------KTEKELFLPFWKFFSKTGG 845
            |:.:.:.:   .|..:|..::.:...|::.|:...||         .....|..|..|...
 Worm   969 GLQQGVRD---NKRTVAHFRIVIEPMSSSSGNKKEERVGFHSHVGHLATWSLHYPLVKMIG---- 1026

  Fly   846 VEITPSKSLPDFN---DLPQSVHLLT 868
             :.|| ||:...|   :|...:||:|
 Worm  1027 -DATP-KSISSKNVEQELNCDLHLVT 1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManIV	NP_609251.2	PLN02701	31..793	CDD:178304	221/847 (26%)
		GH38N_AMII_LAM_like	39..312	CDD:212121	81/293 (28%)
aman-2	NP_505995.2	PLN02701	142..1124	CDD:178304	239/936 (26%)