Protein Alignment LManIV and aman-3

DIOPT Version :10

• Sequence 1: NP_609251.2
• Gene: LManIV / 34204
• FlyBaseID: FBgn0032067
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: NP_001361919.1
• Gene: aman-3 / 172178
• WormBaseID: WBGene00018594
• Length: 1046
• Species: Caenorhabditis elegans
• Alignment Length: 1000
• Identity: 246/1000 - (24%)
• Similarity: 428/1000 - (42%)
• Gaps: 176/1000 - (17%)

  Fly    32 ETKANMVNIHLVPHSHNDVGWLKTVDQSYYGYKNKIHHAGVQYILDSVVSQLLQDPKRRFIQVET 96
            :::...:.::::|.:|.|.|||:|.::         :......|||::...::::.|.||:..|.
 Worm   113 KSRTEKLKVYVLPFTHVDPGWLETFER---------YTKSTNQILDNMHQFMMKNEKMRFMWAEF 168

  Fly    97 AFFAKWWNVQSESMKKVVTKLVNEGRFEFTGGAWSMNDEANVNYQGVIDQFTVGLKFLNETFGSC 161
            .||.:||::|:|.:|:.|.|||.|||.|...|:|.|.||||..:...:|....|.:|:::.||.
 Worm   169 VFFERWWSLQNEQVKEDVKKLVTEGRLELATGSWVMTDEANPYFPVSVDNIVEGFQFIHKNFGI- 232

  Fly   162 GRPRVGWQIDTFGHSREQAAIFAHMGYDGQFFSRMDHNDKDTRMNDLTMEMIWDASESMSGVS-- 224
             :|:..|..|.||:|.....:|...|......:|:.|..|.|..:...:...|......:|..
 Worm   233 -KPQTMWSNDPFGYSNSVPYLFKKSGVHRTVINRIHHKLKQTLQSQKAIPFKWRQYFDATGEDDV 296

  Fly   225 LFSGMLYNFY-------SDTPGFC-FDILCTDQPIIDGDSEEN----NVKQRVDDFISYAKNVSE 277
            |...:.|..|       ||....| ||..........|...|.    ||..:.:..::..:.:||
 Worm   297 LTQILPYTHYDILNSCGSDASVCCEFDFKRMTHWSCPGPKPEKITNANVAAKAEKLVNQLEKMSE 361

  Fly   278 VYITNHIMVPMGGDFQY---EDAKVNYKNMDKLIKYINERQASGSKYNIFYSTPSCYLNSLHQSL 339
            :|....|::..|.||::   |:....:.|...:...||:    ||:..|.:.|.:.|.|    .|
 Worm   362 MYKAPVILMMHGDDFRFDMIEEWNQQHDNFIPVFDEINK----GSRVEIRFGTFTDYFN----DL 418

  Fly   340 ESW---------PNKTQDFFPYAHEKNSFWTGFFTSRPTQKR-------FERDGNHMLQVAKQLS 388
            |.|         |..:.|||||......:|||::|:||..||       ..|:|:.||.:.:
 Worm   419 EKWYSNNKDSEPPTVSGDFFPYMCALGDYWTGYYTTRPFFKRQGRLLHSLIRNGDIMLSMLR--- 480

  Fly   389 VLANLTSEEHKID-----LDYLRQVMGVMQHHDAITGTEKQAVSDDYDRMMYEAIVGAS----NN 444
              .||  ::.||.     |:..|:.:.:.|||||||||.|.:|.|:|..:::.:||..:    |.
 Worm   481 --VNL--KQRKIGENVKRLEAARRNLALFQHHDAITGTSKVSVMDNYSELLHASIVSTNIVLENL 541

  Fly   445 ARDALRLLTNMPYG-EFESCLRLNISECAFTKDGADNVLVTLYNPLAHSSTQYVRIPVKEENYQV 508
            .:..:.|...:..| |.::.:.|..||    |:      :.::|......|...:|.|||....|
 Worm   542 TKSDIDLYPRIHDGIELQTIVDLESSE----KE------IRIFNSHLFEITDVFKIRVKEREVIV 596

  Fly   509 TDEKGRTVPSEVVPVPWQVLALEYRSNDTQHE---LVFKATVNKVSSYSIKKVESSEVKHSSIKK 570
            :.: |:.:.:::.|.        ::.:..:.:   |:|:|||..:|...:|.........:.:.|
 Worm   597 SID-GKIIEAQLEPF--------FQKSKVEKDSFLLLFQATVLPLSMMKVKVQRGDSGGLTKMAK 652

  Fly   571 INPREDN-----NSETV--------VENSVVKLVMDNHTGRLKSVEMNGVSEKI--VQNFGVYKS 620
            |..::.|     :|.|:        :|....|:..|..||.::||.....:.|.  .|:|..||.
 Worm   653 IEAKDTNAWDLGSSWTIASSTSAPNLETPYFKVSNDPITGAIQSVNKLSDNSKFHCQQSFYNYKE 717

  Fly   621 HTSCAYTFRQDGDIELFENDFEFTVYE-----GSLVKEVHQHVNDWISQV-IRIYEGVSRVELEW 679
            ....||..|      |..|..|...|:     |.|.:.::|...:.:.:: |...||.|..|::.
 Worm   718 AGGGAYLMR------LHTNPKEIIEYQWLKVSGPLRQSIYQKSTNVLQRLSIHNVEGPSGEEVDI 776

  Fly   680 MVGPIPIDDKLGSEFVTNFKSEISSNGVFYTDSNGRELMKRVKDKREDFVSDLSRQPVSGNFYPV 744
            .:. |.|..:..:|.:|.|.:: ....:.||||.|.:|::|          |..:.||..|:||:
 Worm   777 SMS-IDITKERNTELMTRFSTK-WDKPLTYTDSVGMQLLRR----------DFYKLPVQSNYYPM 829

  Fly   745 TSRIALQDDTKRLVLLNDRSQGGASLEDGALEMLIHRRHLFNDGGGVGEALNETQYGKGLIARGK 809
            .:...||...:||.::::...|...||.|.:|:.|.|....:||.|:|...:........:.. |
 Worm   830 PTAAVLQSGKQRLSIVSNVEHGARFLESGTVEINIDRILNQDDGKGLGTGPDAIPIDMKPVDM-K 893

  Fly   810 LYLILDSATDGDTVTER----------KTEKELFLPFWKFFSKTGGVEITPSKSLPDFNDL---- 860
            ..||.||.....|...|          ..:..::.|.  .|::       |.|...|..::
 Worm   894 FKLIFDSLESDPTENSRYSTHSFRAQQAVQTIIYPPM--MFNR-------PPKKEEDIEEIEEIS 949

  Fly   861 ----PQSVHLLTLEFFSE-QEILIRFEHFLDKSEGRV------ISFNIRDIFDSLGGLAIRETTL 914
                |..:.|||:....: :::||.:.|....|..:|      :..::.|:...||...:::|.|
 Worm   950 NLKFPCDIQLLTVRPLEDNKQLLILYRHATVCSSQKVGNCGGELKSSLMDLLIKLGAKQVQKTDL 1014

  Fly   915 DG-----------NMPLSDMKRFKF 928
            .|           .:|..::|.|.|
 Worm  1015 SGVTRVGGIIKVEYLPDYELKTFDF 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManIV	NP_609251.2	PLN02701	31..793	CDD:178304	214/827 (26%)
		GH38N_AMII_LAM_like	39..312	CDD:212121	76/289 (26%)
aman-3	NP_001361919.1	PLN02701	117..978	CDD:178304	233/933 (25%)
		GH38N_AMII_GMII_SfManIII_like	118..452	CDD:212120	96/352 (27%)