Protein Alignment LManIV and Man2b2

DIOPT Version :10

• Sequence 1: NP_609251.2
• Gene: LManIV / 34204
• FlyBaseID: FBgn0032067
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: NP_032576.2
• Gene: Man2b2 / 17160
• MGIID: 1195262
• Length: 1018
• Species: Mus musculus
• Alignment Length: 1090
• Identity: 283/1090 - (25%)
• Similarity: 476/1090 - (43%)
• Gaps: 207/1090 - (18%)

  Fly    10 LSILLVLFAKQSEAVCGYESCPETKANMVNIHLVPHSHNDVGWLKTVDQSYYGYKNKIHHAGVQY 74
            |..||:|:.:.::           .|..:...:|||||.||||:.||.:|...|...::
Mouse    10 LGQLLLLWPRAAQ-----------PAGPIRAFVVPHSHMDVGWVFTVQESMRAYAANVY------ 57

  Fly    75 ILDSVVSQLLQDPKRRFIQVETAFFAKWWN-VQSESMKKVVTKLVNEGRFEFTGGAWSMNDEANV 138
              .:||::|::..:||||.||..||..||: |.||..|:.|.:|::|||.||..|...|:|||..
Mouse    58 --TTVVAELVRGGQRRFIAVEQEFFRLWWDGVASEQQKQQVRQLLHEGRLEFVLGGQVMHDEAVT 120

  Fly   139 NYQGVIDQFTVGLKFLNETFGSCGRPRVGWQIDTFGHSREQAAIFAHMGYDGQFFSRMDHNDKDT 203
            :....|.|.|.|..||.||||.  ||:..|.:|.||.|.....:||..|::....||:|::.||.
Mouse   121 HLDDQILQLTEGHGFLYETFGI--RPQFSWHVDPFGASATTPTLFALAGFNAHLISRIDYDLKDA 183

  Fly   204 RMNDLTMEMIWDASESMSG-VSLFSGML--YNF-------YSDTPGFCFD-ILCTDQPIIDG--- 254
            ......::.:|..|.|:|| ..:|:.::  |::       :|:..||.:: :....:|..||
Mouse   184 MQEAQMLQFVWHGSPSLSGQQEIFTHVMDHYSYCTPSHIPFSNRSGFYWNGVAVFPEPPPDGVYP 248

  Fly   255 -DSEE---NNVKQRVDDFISYAKNVSEVYITNHIMVPMGGDFQYEDAKVNYKNMDKLIKYINERQ 315
             .||.   .|:....:..::..|..:..:.|.|::.|.|.|.|:.:|.|.:.|||.|:.|||:|.
Mouse   249 NMSEPVTGANIHLYAEALVANVKQRAAWFRTPHVLWPWGCDKQFFNASVQFDNMDPLLDYINQRT 313

  Fly   316 ASGSKYNIFYSTPSCYLNSLHQSLESWPNKT-QDFFPYAHEKNSFWTGFFTSRPTQKRFERDGNH 379
            |... .::.|:|.:.|..:||.:..:|..:. |||.||:.|....||||:|||.|.|...|..:.
Mouse   314 AQFG-ISVQYATLNDYFQALHATNMTWGIRDHQDFLPYSSEPLQAWTGFYTSRSTLKGLARQASA 377

  Fly   380 MLQVAKQLSVLANLTSEEHKID-------LDYLRQVMGVMQHHDAITGTEKQAVSDDYDRMMYEA 437
            :|...:.:............:|       |..||..:..:||||||||||...|.:.|...:...
Mouse   378 LLYAGESMFTRYMWPDPSGTLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVKNMYTEHLRMG 442

  Fly   438 IVGASNNARDALRLLTNMPYG----------------EFESCLRLNISECAFTKDGADNVLVTLY 486
            ::|..       :|:.::..|                :....|.::.....::        .::|
Mouse   443 MLGVR-------KLMVSIALGGPPGSGTGAPKDIMGPQVTPVLSVDTRPVGYS--------ASVY 492

  Fly   487 NPLAHSSTQYVRIPVKEENYQVTDEKGRTVPSEVV-----PVPWQVL------ALEYRSNDTQHE 540
            ||||...|..:.:.|...|..||||.|..|.:::.     |..:.:|      .|.||     |.
Mouse   493 NPLAWKITTIITLTVAFPNVSVTDELGHPVSTQIQNSTKDPSAYDLLILTTIPGLNYR-----HY 552

  Fly   541 LVFKATVNKVSSYSIKKVESSEVKHSSIKKINPREDNNSETVVENSVVKLVMDNHTGRLKSVE-- 603
            .|..|..::..:..:....::.:|.|...:..|.::......|.|....|:.|..|..|.|::
Mouse   553 QVMHARGDQAGTRELVAPRANTLKFSLKLRNQPSQEGKRLVPVMNDCYILLFDQDTNMLHSIQDR 617

  Fly   604 MNGVSEKIVQNFGVYKSH-------TSCAYTFRQDGDIELFENDFEFTVYEGSLVKEVHQHVNDW 661
            .:..:.::.|.|..|:::       .|..|.|..:...|.........:..|:||.::.|:...:
Mouse   618 QSNRTVRMTQEFLEYQANWDVKQGPISDNYLFAPNNTAEPSWEAVGMEMVAGTLVTDIRQYFYRY 682

  Fly   662 ISQVIRIYE-----------G---VSRVELEWMVGPIPIDDKLGSEFVTNFKSEISSNGVFYTDS 712
            |:....||.           |   ..|:|.::.|||:    .|..|.:....|:::|..|.|:|:
Mouse   683 ITDQEYIYSIHTRLAHPSLAGELLCQRIEQQYRVGPL----DLNREAILRTSSDLNSQQVLYSDN 743

  Fly   713 NGRELMKRVKDKREDFVSDLSRQPVSGNFYPVTSRIALQDDTKRLVLLNDRSQGGASLEDGALEM 777
            ||.::.:|   ..:.|.|:    |:..|:||:.....::||..|||||.:|..|.:|..:|.:|:
Mouse   744 NGYQMQRR---PYKAFKSN----PIPRNYYPMVQSAFIEDDKSRLVLLAERPHGVSSQGNGQVEV 801

  Fly   778 LIHRRHLFNDGG---GVGEALNETQYGKGLIARGKLYLILDSATDGDTVTERKTEKELFLPFWKF 839
            ::||| |:|:..   .....||:|.     |....|:|:|...:   |:|.......:.|
Mouse   802 MLHRR-LWNNLAWDLKYNLTLNDTS-----IVHPVLWLMLGPKS---TMTALHPRSGVAL----- 852

  Fly   840 FSKTGGVEITPSKSLPDFN------------DLPQSVHLLTLEF----FSE-------------- 874
              :.|.|.:.  |.|.|..            .||.::||..|..    :|.
Mouse   853 --QHGPVVLL--KELADEETPVHGPHNPWPVTLPPNLHLQILSVPGWTYSRSHAQHLRNLQRGHP 913

  Fly   875 -------QEILIRFEHFLDKSEGRVIS----FNIRDIFDSLGG-LAIRETTLDGNMPLSDMKRFK 927
                   |.:|:|..|..:..|..|:|    .:::.:...||. :|:.|.:|.|...:..::|:.
Mouse   914 EKPQANLQRVLLRLRHLYEAGEDPVLSRPATVDLKVVLRGLGSVVAVEERSLTGTWDVQMLQRWH 978

  Fly   928 FHAQESGTKPSSVE-YSTAQHKPLEAVKSDEASLFAVTLYPMQIRTFIIK 976
            :     .||...:: :.|:..:|      ...|:  :|:||.:||||.||
Mouse   979 W-----STKTDHLKGHPTSPPRP------PGGSI--ITVYPKEIRTFFIK 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManIV	NP_609251.2	PLN02701	31..793	CDD:178304	230/841 (27%)
		GH38N_AMII_LAM_like	39..312	CDD:212121	97/291 (33%)
Man2b2	NP_032576.2	PLN02701	27..807	CDD:178304	227/822 (28%)
		GH38N_AMII_Epman_like	27..352	CDD:212122	112/335 (33%)