DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManIV and Man2a2

DIOPT Version :9

Sequence 1:	NP_609251.2	Gene:	LManIV / 34204	FlyBaseID:	FBgn0032067	Length:	978	Species:	Drosophila melanogaster
Sequence 2:	NP_766491.2	Gene:	Man2a2 / 140481	MGIID:	2150656	Length:	1152	Species:	Mus musculus

Alignment Length:	1075	Identity:	276/1075 - (25%)
Similarity:	445/1075 - (41%)	Gaps:	226/1075 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 VNIHLVPHSHNDVGWLKTVDQSYYGYKNKIHHAGVQYILDSVVSQLLQDPKRRFIQVETAFFAKW 102
            :.:.:|||||||.||:||.|: ||..:       .|:||:|:||:|.:||:|||:..|.:|||||
Mouse   166 LQVFVVPHSHNDPGWIKTFDK-YYTEQ-------TQHILNSMVSKLQEDPRRRFLWAEVSFFAKW 222

  Fly   103 WNVQSESMKKVVTKLVNEGRFEFTGGAWSMNDEANVNYQGVIDQFTVGLKFLNETFGSCGRPRVG 167
            |:..|...:..|.:||..|:.|...|.|.|.||||.:|..::||...|.::|....|:  .||.|
Mouse   223 WDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLERNLGA--TPRSG 285

  Fly   168 WQIDTFGHSREQAAIFAHMGYDGQFFSRMDHNDKD----TRMNDLTMEMIWDASESMSGVSLFSG 228
            |.:|.||||.....:............|:.:..|.    |...:.....:||   |.|...:|..
Mouse   286 WAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQMWD---SDSSTDIFCH 347

  Fly   229 MLYNFYS-DTPGFCF---DILCT-DQPIIDGDS------------EENNVKQRVDDFISYAKNVS 276
            |: .||| |.|..|.   .|.|. |...:.|..            .|.||..|....:...:..|
Mouse   348 MM-PFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVADRAALLLDQYRKKS 411

  Fly   277 EVYITNHIMVPMGGDFQYE-----DAKVNYKNMDKLIKYINER-----QASGSKYNIFYSTPSCY 331
            .::.:|.::||:|.||:|:     ||:  :.|..:|..::|.:     ||.       :.|.|.|
Mouse   412 RLFRSNVLLVPLGDDFRYDKPQEWDAQ--FFNYQRLFDFLNSKPEFHVQAQ-------FGTLSEY 467

  Fly   332 LNSLHQSL--------ESWPNKTQDFFPYAHEKNSFWTGFFTSRPTQKRFERDGNHMLQVAKQLS 388
            .::|::..        ..:|..:.|||.||..::.:|||::||||..|..:|.....|:.|:.|.
Mouse   468 FDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEILY 532

  Fly   389 VLA-------NLTSEEHKIDLDYL---RQVMGVMQHHDAITGTEKQAVSDDYDRMMYEAIVGASN 443
            .||       .|..:....|...|   |:.:|:.|||||||||.|:||..||...:..::|....
Mouse   533 SLALAHARRSGLAGQYPLSDFALLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVSLKQ 597

  Fly   444 ---NARDALRLLTNMPYGEFESCLRLNISECAFTKDG----------ADNVLVTLYNPLAHSSTQ 495
               ||...|.|.....|........|.:.:...:.|.          :....|.::|||......
Mouse   598 VIINAAHYLVLGDQETYSFDPGTPFLQMDDSRVSHDALPERTVIRLDSSPRFVVVFNPLEQERLS 662

  Fly   496 YVRIPVKEENYQVTDEKGRTVPSEV----------------VPVPWQVLALEYRSNDTQHEL--- 541
            .|.:.|.....:|..|:|:.:..::                |.||.::..|.......|.:|
Mouse   663 VVSLLVNSPRVRVLSEEGQPLSVQISVHWSSATDMVPDVYQVSVPVRLPGLGLGVLQLQPDLDGP 727

  Fly   542 --------VF----KATVNKVSSYSIKKVESSEVKHSSIKKINPREDNNSETVVENSVVKLVMDN 594
                    |:    |.:|::.|::.::.|:|..                |:..:.|..:::....
Mouse   728 YTLQSSVRVYLNGVKLSVSRQSAFPVRVVDSGA----------------SDFAISNRYMQVWFSG 776

  Fly   595 HTGRLKSVEMNGVSEKIVQ----NFGVYKSHT----SCAYTFRQDGDIELF--ENDFEFTVYEGS 649
            .||.|||:..  |.|:..|    .|.||.:.|    |.||.|..|.:.:.:  :......|.||.
Mouse   777 LTGLLKSIRR--VDEEQEQQMELEFLVYGTRTSKDKSGAYLFLPDSEAKPYVPKKPPVLRVTEGP 839

  Fly   650 LVKEV---HQHVNDWISQVIRIYE--GVSRVELEWMVGPIPIDDKLGSEFVTNFKSEISSNGVFY 709
            ...||   ::|.:    ||||:|.  ||..:.|: |...:.|.|.:..|......::|.|.|.|:
Mouse   840 FFSEVAVYYEHFH----QVIRLYNLPGVEGLSLD-MSFQVDIRDYVNKELALRIHTDIDSQGTFF 899

  Fly   710 TDSNGRELMKRVKDKREDFVSDLSRQPVSGNFYPVTSRIALQDDTKRLVLLNDRSQGGASLEDGA 774
            ||.||.::..|         ..|.:.|:..||||:.....:||..:||.|...::.|.:||.:|.
Mouse   900 TDLNGFQIQPR---------QYLKKLPLQANFYPMPVMAYIQDSQRRLTLHTAQALGVSSLGNGQ 955

  Fly   775 LEMLIHRRHLFNDGGGVGEALNETQYGKGLIARGKLYLILDSATDGDTVTERKTEKE-------- 831
            ||:::.||.:.:|..|:|:.|.:.:     |...:..|:|:..|.......::.|:.
Mouse   956 LEVILDRRLMQDDNRGLGQGLKDNK-----ITCNRFRLLLERRTTMSPEVHQEQERSTSYPSLLS 1015

  Fly   832 -----------LFLPFWKFFSKTGGVEITPSKSLPDFNDLPQSVHLLTLEFF--------SEQEI 877
                       |.||    .:|..|.........|..:.||...|||.|...        ::..:
Mouse  1016 HLTSMYLSTPPLVLP----VAKRQGTSPALRSFHPLASPLPCDFHLLNLRMLPAEDTLPATDSAL 1076

  Fly   878 LIRFEHFLDKSEGRVISFNIRDIFDSLGGLAIRETTLDGNMPLSDMKRFKFHAQE-SGTKPSSVE 941
            ::..:.|....|.:.:.||.              ||..|.:.|..:    ||..: :..:|:|:.
Mouse  1077 ILHRKGFDCGLEAKNLGFNC--------------TTSQGKLALGSL----FHGLDVTFLQPTSLT 1123

  Fly   942 YSTAQHKPLEAVKSDEASLFAVTLYPMQIRTFIIK 976
            .......|..:..        ::|.||:|.||.::
Mouse  1124 LLYPLASPSNSTD--------ISLEPMEISTFRLR 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManIV	NP_609251.2	GH38N_AMII_LAM_like	39..312	CDD:212121	96/298 (32%)
		Alpha-mann_mid	359..434	CDD:214875	33/84 (39%)
		Glyco_hydro_38C	483..973	CDD:285047	124/563 (22%)
Man2a2	NP_766491.2	PLN02701	140..1151	CDD:178304	276/1075 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810