Protein Alignment LManIV and man2b2

DIOPT Version :10

• Sequence 1: NP_609251.2
• Gene: LManIV / 34204
• FlyBaseID: FBgn0032067
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: NP_001106515.1
• Gene: man2b2 / 100127706
• XenbaseID: XB-GENE-1006292
• Length: 990
• Species: Xenopus tropicalis
• Alignment Length: 1093
• Identity: 287/1093 - (26%)
• Similarity: 477/1093 - (43%)
• Gaps: 237/1093 - (21%)

  Fly    12 ILLVLFAKQSEAVCGYESCPETKANMVNIHLVPHSHNDVGWLKTVDQSYYGYKNKIHHAGVQYIL 76
            :||||.:... .||.:.:.|      :...::||||.||||:.||.:|.:.|...::
 Frog     3 VLLVLLSAWG-CVCTHSAQP------IQAFVIPHSHMDVGWVYTVQESMHAYAANVY-------- 52

  Fly    77 DSVVSQLLQDPKRRFIQVETAFFAKWWNVQSESM-KKVVTKLVNEGRFEFTGGAWSMNDEANVNY 140
            .:||.:|::..:||||.||..||..||.:.:.:: |:.|.:|:.|||.||..|...|:|||....
 Frog    53 TTVVEELMRGDRRRFIVVEQEFFRLWWKLFAGNVEKQQVHQLMREGRLEFVIGGQVMHDEALTTI 117

  Fly   141 QGVIDQFTVGLKFLNETFGSCGRPRVGWQIDTFGHSREQAAIFAHMGYDGQFFSRMDHNDKDTRM 205
            ...|.|.|.|..|:.||||.  |||..|.:|.||.|.....:||..|::|...||:|::.|....
 Frog   118 DDQILQLTEGHGFIYETFGV--RPRFSWHVDPFGASAASPTLFAMAGFNGHLISRIDYDTKADMQ 180

  Fly   206 NDLTMEMIWDASESMSG-VSLFSGML--YNF-------YSDTPGFCFD-ILCTDQPIIDGDSEEN 259
            |...::.||.||.|:|. ..:|:.::  |::       :||..||.:: |.....|..||.....
 Frog   181 NGKELQFIWRASPSLSDKQEIFTHVMDQYSYCTPSYIPFSDRSGFYWNGIAVFPDPPKDGMYPNM 245

  Fly   260 NVKQRVDDFISYA----KNVSE---VYITNHIMVPMGGDFQYEDAKVNYKNMDKLIKYINERQAS 317
            ::....|....||    ||:.|   .:.::.::.|.|.|.|:.:|.|.:.|||.|:.|||:....
 Frog   246 SLPVTADTIHPYAETMVKNIKERAAWFRSSDVLWPWGCDKQFFNASVQFNNMDLLLDYINKHTEF 310

  Fly   318 GSKYNIFYSTPSCYLNSLHQSLESWPNK-TQDFFPYAHEKNSFWTGFFTSRPTQKRFERDGNHML 381
            |  ..:.|||...|..:|:....:|..: :|||.||:.:.:..||||:|||...|...|..:.:|
 Frog   311 G--VTVQYSTLGDYFKNLYNRNLTWGLRGSQDFLPYSSDSSQAWTGFYTSRNVLKGVARRASSLL 373

  Fly   382 QVAKQL---SVLANLTSEEHKI----DLDYLRQVMGVMQHHDAITGTEKQAVSDDYDRMMYEAIV 439
            ..|:..   .:|.:.|....|:    .|..||..:..:||||.|||||...|.|.|   :...:.
 Frog   374 YAAESAFAQHLLKHPTGSVEKVWAMEQLRSLRWAVSEVQHHDGITGTESPKVRDMY---IANLLQ 435

  Fly   440 GASNNARDALRLLTNMPYGEFESCLRLNISECAFTKDGADNVLVTLYNPLAHSSTQYVRIPVKEE 504
            ||:...:....::.::...:..||             |...:.:|:|||||...|.:|.:|:...
 Frog   436 GAAGVRKLMAAIVMDLYSSQANSC-------------GNGYINITVYNPLAWDVTTFVLVPMNNS 487

  Fly   505 NYQVTDEKGRTVPSEVVPVPWQVLALEYRSNDTQ-------HELVFKATVNKVS--SYSIK---- 556
            ...|.|:.|:.||:::             .|.|:       |.||   |:..:|  .||||
 Frog   488 VSGVYDKFGQPVPAQI-------------QNATEPSNAFDLHILV---TLKGLSYGRYSIKLGSC 536

  Fly   557 ------KVESSEVKHSSIKKINPREDNNSETVVENSVVKLVMDNHTGRLKSVEMNGVSE--KIVQ 613
                  .|...::......|.|..:..|..|.:.|....:|:|.:|..|.|:.....::  ::.|
 Frog   537 DAANDRLVTGRKITFVRQPKRNKAKRQNLVTPIMNDCYTVVIDQNTNLLHSITARESNQTVQVTQ 601

  Fly   614 NFGVYKSHTSCAYTFRQDGDIEL--FENDFEFT---------------VYEGSLVKEVHQHVNDW 661
            .|..|.|          :|||..  ..:::.||               :..|.||.|:.|:....
 Frog   602 EFLEYHS----------NGDISKGPISDNYLFTSTGPAISAYKAVGLEIIAGKLVTEIRQYFYSN 656

  Fly   662 I----------SQVIRIYEGVSR------VELEWMVGPIPIDDKLGSEFVTNFKSEISSNGVFYT 710
            |          |::..:.||..:      :|..:.|||:    .|..|.:....:::.::.:.||
 Frog   657 ITAQTYLYAVYSRIYNVPEGYDKSLVCHHIEQSYRVGPM----DLNRESIIRTSTDLRTDRLIYT 717

  Fly   711 DSNGRELMKRVKDKREDFVSDLSRQPVSGNFYPVTSRIALQDDTKRLVLLNDRSQGGASLEDGAL 775
            |:||.::.:| :.|..|      ...|:.|:||:.....::|::.|||.|::|:.|.:|.::|.:
 Frog   718 DNNGYQMQRR-QFKNYD------TNTVARNYYPMVRTAYIEDNSTRLVFLSERAHGVSSQDNGEV 775

  Fly   776 EMLIHRRHLFND---GGGVGEALNETQYGKGLIARGKLYLILDSATDGDTVTER----------- 826
            |:::||| |:|:   .......||:|.     :.|..::|:|.|......:.:|
 Frog   776 EIMLHRR-LWNNLEWDLNYNLTLNDTS-----VVRPTIWLMLGSRALAGALYQRLGMALEHRPLV 834

  Fly   827 ----KTEKELFLPFWKFFSKTGGVEITPSKSLPDFNDLPQSVHLLTLE----FFSEQ-------- 875
                .|.:|      |...||..:.||          ||.::||..|.    |:|.:
 Frog   835 IYSLHTGQE------KRSYKTTDLPIT----------LPDNIHLQILSIPGWFYSSRHHEHMQDI 883

  Fly   876 -------------EILIRFEHFLDKSEGRVIS----FNIRDIFDSLGGLA-IRETTLDGNMPLSD 922
                         .:|:|.:|..:.:|..|:|    .|::.:...||.:: :.|.:|.|...:..
 Frog   884 HTGNIRDNVADFHRVLLRLQHLYETNEDPVLSKPVTINLQSLLKGLGTVSLVEERSLTGTWDIHT 948

  Fly   923 MKRFKFHAQESGTKPSSVEYSTAQHKPLEAVKSDEASLFAVTLYPMQIRTFII 975
            :||:|:.|...||........|:.              |.:||.|.:|||..:
 Frog   949 LKRWKWKANIKGTDQREHTLGTSD--------------FTITLSPKEIRTLFV 987

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManIV	NP_609251.2	PLN02701	31..793	CDD:178304	233/845 (28%)
		GH38N_AMII_LAM_like	39..312	CDD:212121	97/291 (33%)
man2b2	NP_001106515.1	PLN02701	19..783	CDD:178304	231/835 (28%)
		GH38N_AMII_Epman_like	22..346	CDD:212122	111/335 (33%)