Protein Alignment LManIV and man2a1

DIOPT Version :10

• Sequence 1: NP_609251.2
• Gene: LManIV / 34204
• FlyBaseID: FBgn0032067
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: NP_001163963.1
• Gene: man2a1 / 100036612
• XenbaseID: XB-GENE-961025
• Length: 1150
• Species: Xenopus tropicalis
• Alignment Length: 1070
• Identity: 276/1070 - (25%)
• Similarity: 446/1070 - (41%)
• Gaps: 220/1070 - (20%)

  Fly    38 VNIHLVPHSHNDVGWLKTVDQSYYGYKNKIHHAGVQYILDSVVSQLLQDPKRRFIQVETAFFAKW 102
            :.:.||||||||.|||||.|..:        ....|:||:::|.:|.:|..|:|:..|.::|:||
 Frog   168 LQVFLVPHSHNDPGWLKTFDDYF--------RDQTQHILNNMVIKLQEDKNRKFMWSEISYFSKW 224

  Fly   103 WNVQSESMKKVVTKLVNEGRFEFTGGAWSMNDEANVNYQGVIDQFTVGLKFLNETFGSCGRPRVG 167
            |:......|:.|.:|:...:||...|.|.|.|||..:|..::||...|.::|.:..|.  :|:.|
 Frog   225 WDGIDNQKKEAVKRLIELEQFEIVTGGWVMPDEATPHYFSLVDQLIEGHQWLEKNLGV--KPKSG 287

  Fly   168 WQIDTFGHSREQAAIFAHMGYDGQFFSRMDHNDKDTRMNDLTMEMIWDASESMSGVSLFSGMLYN 232
            |.||.||||...|.|....|.......|:.::.|....:..|:|..|..:..:...:.....:..
 Frog   288 WAIDPFGHSPTMAYILKSSGLSNMLIQRVHYSIKKYFASKQTLEFFWRQNWDLGHSTDILCHMMP 352

  Fly   233 FYS-DTPGFC---------FD--------ILC---TDQPIIDGDSEENNVKQRVDDFISYAKNVS 276
            ||| |.|..|         ||        :.|   ....:|:    |.||:.|....:...:..|
 Frog   353 FYSYDVPHTCGPDPKICCQFDFKRLPGSRVSCPWRVPPEVIN----EGNVQHRAWMILDQYRKKS 413

  Fly   277 EVYITNHIMVPMGGDFQYEDA---KVNYKNMDKLIKYINERQASGSKYNIFYSTPSCYLNSLHQ- 337
            ::|.|..::||:|.||:|.|:   ...|:|..||..|:|.......|..  :.|.|.|..:|.:
 Frog   414 KLYRTKVLLVPLGDDFRYTDSLEWDQQYENYQKLFSYMNSHPELHVKAQ--FGTISDYFKALRKA 476

  Fly   338 ------SLESWPNKTQDFFPYAHEKNSFWTGFFTSRPTQKRFERDGNHMLQVAK----------- 385
                  :.:|:|..:.|||.||...:.:|:|:|||||..||.||.....|:.|:
 Frog   477 GNVDDPNSQSFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRLERVMESHLRAAEILYSFALVQMN 541

  Fly   386 QLSVLANLTSEEHKIDLDYLRQVMGVMQHHDAITGTEKQAVSDDYDRMMYEAIVGASNNARDALR 450
            :...|.:..|.||...|...|:.:|:.|||||||||.|..|..||...::.:::.......||..
 Frog   542 KFDKLQSFPSVEHYKLLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMNLKRVIIDAAH 606

  Fly   451 LLTNMPYGEFESCLRLNISECAFTKD----GADNV-------------LVTLYNPLAHSSTQYVR 498
            :|..    :.:.....|.|...|:.|    ..|::             .:|:|||........|.
 Frog   607 VLVL----KDKDTYAYNPSSPFFSMDDVQPSQDSLPQKTVIKITEIPRYLTVYNPTEQERYSVVS 667

  Fly   499 IPVKEENYQVTDEKGRTVPSEVVPVPWQVLALEYRSNDT-----QHELVFKATVNK--VSSYSIK 556
            :.|.....:|....|:.:.:::..| |        :.|:     .:::.|.|.:..  ::.|.:.
 Frog   668 VYVSSSKVKVISASGKALKAQISAV-W--------NGDSAPLQDMYQVSFLAYLPALGLAVYKLV 723

  Fly   557 KVESSEV-----------KHSSIKKINPREDNN----------SETVVENSVVKLVMDNHTGRLK 600
            :.|:||.           ||   |.||  .|.|          .:..:||:.:||...: :|.|:
 Frog   724 EAENSESIKADYTIFVQGKH---KNIN--SDGNFRIKEVNIVVGDVTIENTYLKLWFSS-SGLLE 782

  Fly   601 SVEM--NGVSEKIVQNFGVY----KSHTSCAYTFRQDGDIELFENDFE--FTVYEGSLVKEV--- 654
            .::.  :|.:..:..:|..|    ....|.||.|..||:.:.:.|...  ..|..||:..||
 Frog   783 KIQSKEDGKTHGVKVDFIWYGTTNNRDKSGAYLFLPDGEAKPYINADPPVVRVTHGSIFSEVVVF 847

  Fly   655 HQHVNDWISQVIRIY-----EGVSRVELEWMVGPIPIDDKLGSEFVTNFKSEISSNGVFYTDSNG 714
            .:|    ::..:|:|     ||.|    ..:...:.|..:...|.|....|:|:|...||||.||
 Frog   848 FKH----LTHTVRLYNVHGLEGQS----PEITNVVDIRGEFNREIVMRITSDINSKHRFYTDLNG 904

  Fly   715 RELMKRVKDKREDFVSDLSRQPVSGNFYPVTSRIALQDDTKRLVLLNDRSQGGASLEDGALEMLI 779
            .::..|         ..||:.|:..|.||:||...:|||..||.|.:.:|.|.||.:.|.||:.:
 Frog   905 YQIQPR---------RTLSKLPIQANVYPMTSMAYIQDDASRLTLHSAQSLGVASSKSGQLEVFL 960

  Fly   780 HRRHLFNDGGGVGEALNETQYGKGLIARGKLYLILDSATDGDTVTERKTEKELFLP-----FWKF 839
            .||.:.:|..|:|:.:.:.:....|..     |:|:.....|   |::.||.:..|     ....
 Frog   961 DRRLMQDDNRGLGQGVQDNKITSNLFR-----LLLEKRFGKD---EKEDEKPVSYPSILSHITSM 1017

  Fly   840 F----------SKTGGVEITPSKSLPDFNDLPQSVHLLTLEFF--------SEQEILIRFEHFLD 886
            |          :...|..:..:..||..:.:|..||||.|...        |::..||......|
 Frog  1018 FLNHPVIPMAATSDSGSSVLLNAFLPLTSSMPCDVHLLNLRTIQAKVGPIPSDEAALILHRKGFD 1082

  Fly   887 KSEGRVISFNIRDIFDSLGGLAIRETTLDGNMPLSDMKRFKFHAQESGTK-----PSSVEYSTAQ 946
                  ..|:.:|:     ||..  :|..|.:.:        |...:|..     |||:   |..
 Frog  1083 ------CKFSNKDL-----GLLC--STTQGKVSV--------HRLFNGFNIESLIPSSL---TLM 1123

  Fly   947 HKPLEAVKSDEASLFAVTLYPMQIRTFIIK 976
            |.     .|:..:...:.:..|.|:||.||
 Frog  1124 HS-----SSNSKNTTEIRISTMDIKTFRIK 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManIV	NP_609251.2	PLN02701	31..793	CDD:178304	233/857 (27%)
		GH38N_AMII_LAM_like	39..312	CDD:212121	90/296 (30%)
man2a1	NP_001163963.1	PLN02701	130..1150	CDD:178304	276/1070 (26%)