Protein Alignment Bace and LOC613063

DIOPT Version :10

• Sequence 1: NP_609235.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_001136375.1
• Gene: LOC613063 / 613063
• XenbaseID: XB-GENE-29099015
• Length: 399
• Species: Xenopus tropicalis
• Alignment Length: 398
• Identity: 164/398 - (41%)
• Similarity: 229/398 - (57%)
• Gaps: 31/398 - (7%)

  Fly     1 MFKTIAVVVLLAA---LASAELHRVPILK----EQNFVKTRQNV---LAEKSYLRTKYQLPSLRS 55
            |...:..|||||:   ...:.|.|:|:.|    ...|.:..::|   ||.:..|:.....|....
 Frog     1 MASLLVWVVLLASSLLQPGSALIRIPLKKFPSIRHTFTEAGKDVKELLANEVPLKYSPGFPPSGE 65

  Fly    56 VDEEQLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCK--SDACLTHNQYDSSASST 118
            ...|.|.|.::..|||.|.:|:|.|:|.|:||:|||||||||..|.  ..||..|::||||.|||
 Frog    66 PTPEALKNYLDAQYYGEIGLGSPPQNFTVVFDTGSSNLWVPSVHCSMLDIACWMHHKYDSSKSST 130

  Fly   119 YVANGESFSIQYGTGSLTGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESL 183
            ||.||.:|:||||||||:||||.|||.:..|:::.|.|.|:..:||..|..|.|||||||||..:
 Frog   131 YVKNGTAFAIQYGTGSLSGYLSKDTVTIGNLAVKGQIFGEAVKQPGVTFVAAKFDGILGMAYPVI 195

  Fly   184 AVDGVAPPFYNMVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQ 248
            :||||.|.|.|:::|.||::::|||||.|:..:..||||:.||:|...|:|...|:.::.:.|||
 Frog   196 SVDGVPPVFDNIMAQKLVESNIFSFYLNRNPDTQPGGELLLGGTDPKYYTGDFHYLSVTRKAYWQ 260

  Fly   249 FTMAGSSI-DGYSLC-DDCQAIADTGTSLIVAPYNAYITLSEILN----VGEDGYLDCSSVSSLP 307
            ..|....: |..:|| ..|:.|.|||||||..|......|.:.:.    :.....:.|..|.:||
 Frog   261 IHMDQLGVGDQLTLCKGGCEVIVDTGTSLITGPLEEVTALQKAIGAVPLIQGQYMVQCDKVPTLP 325

  Fly   308 DVTFNIGGTNFVLKPSAYI--IQSDGN--CMSAFEYMGTD-------FWILGDVFIGQYYTEFDL 361
            .::..:||..:.|....||  :...|:  |:|.|  ||.:       .||||||||||||:.||.
 Frog   326 VISLTLGGQVYTLTGEQYIMKVSQRGSTICLSGF--MGLNIPPPAGPLWILGDVFIGQYYSVFDR 388

  Fly   362 GNNRIGFA 369
            .|:.:|||
 Frog   389 ANDCVGFA 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_609235.1	pepsin_retropepsin_like	59..369	CDD:472175	146/328 (45%)
LOC613063	NP_001136375.1	A1_Propeptide	24..50	CDD:462326	6/25 (24%)
		Cathepsin_D2	73..397	CDD:133157	146/326 (45%)