Protein Alignment Bace and Pga3

DIOPT Version :10

• Sequence 1: NP_609235.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_068521.1
• Gene: Pga3 / 60372
• RGDID: 621573
• Length: 387
• Species: Rattus norvegicus
• Alignment Length: 392
• Identity: 151/392 - (38%)
• Similarity: 219/392 - (55%)
• Gaps: 37/392 - (9%)

  Fly     8 VVLLAALASAELHRVPILKEQNFVKTRQNVLAE----KSYLRTKYQLPSLR-----------SVD 57
            |:.|.||:.. |.::|::|    :|:.:..|.|    |.||. ||  |..|           ||.
  Rat     6 VLGLVALSEC-LVKIPLMK----IKSMRENLRESHMLKDYLE-KY--PRSRAHVLLEQRRNPSVT 62

  Fly    58 EEQLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKSDACLTHNQYDSSASSTYVAN 122
            .|.:.|.:::.|.|.||||||.|.|||:.|:|||:|||||..|.|.||..|..::...|||::.:
  Rat    63 YEPMRNYLDLVYIGTISIGTPPQEFKVVLDTGSSDLWVPSIYCSSPACAHHKVFNPLQSSTFLVS 127

  Fly   123 GESFSIQYGTGSLTGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESLAVDG 187
            |...::.||:|.::|:|:.|||.:..|::.:|.|..|..|||.....|.||||||:.|.:|.:.|
  Rat   128 GRPVNVAYGSGEMSGFLAYDTVKIGDLTVVAQAFGLSLEEPGRFMEHAVFDGILGLGYPNLGLQG 192

  Fly   188 VAPPFYNMVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQFTMA 252
            |.|.|.|:..|||:..::|:|||:  .....|..|:.||.|.|.|.|.|.:||:|:..|||..:.
  Rat   193 VTPVFDNLWIQGLIPQNLFAFYLS--SKDEKGSVLMLGGVDPSYYHGELHWVPVSKPSYWQLAVD 255

  Fly   253 GSSIDGYSL-CD-DCQAIADTGTSLIVAPYNAYITLSEILNVGEDG----YLDCSSVSSLPDVTF 311
            ..|::|..: || .||.|.||||||:..|.::.:.:..::.....|    :|.|.::::|||:.|
  Rat   256 SISMNGEIIACDGGCQGIMDTGTSLVTGPRSSILNIQNLIGAKASGDGEYFLKCDTINTLPDIVF 320

  Fly   312 NIGGTNFVLKPSAYIIQSDG-NCMSAFEYMGTD-----FWILGDVFIGQYYTEFDLGNNRIGFAP 370
            .|....:.:..||||.:... ||.|.||....|     .|:|||||:..|:|.||..|||||.|.
  Rat   321 TIDSVTYPVPASAYIRKDHSHNCRSNFEESTDDPSDPELWVLGDVFLRLYFTVFDRANNRIGLAS 385

  Fly   371 VA 372
            .|
  Rat   386 AA 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_609235.1	pepsin_retropepsin_like	59..369	CDD:472175	130/321 (40%)
Pga3	NP_068521.1	A1_Propeptide	18..44	CDD:462326	8/30 (27%)
		pepsin_retropepsin_like	64..385	CDD:472175	130/322 (40%)